Buying a home in Big Pine Key, Florida does not have to be difficult - Homes.com makes home buying a breeze. With 140 homes for sale in Big Pine Key, Florida, you can search by price, bedrooms, neighborhood, and even by property type. Search Big Pine Key homes for sale, foreclosures, MLS listings, and more. Make an informed decision with Big Pine Key school data, neighborhood information, find Big Pine Key real estate agents, and research home values in Big Pine Key, FL. Homes.com has everything you need but the house keys.