Buying a home in Colleton County, South Carolina doesn't have to be difficult - Homes.com makes home buying a breeze. With 902 homes for sale in Colleton County, South Carolina, you can search by price, bedrooms, neighborhood, and even by property type. Search Colleton County homes for sale, foreclosures, MLS listings, and more. Make an informed decision with Colleton County school data, neighborhood information, find Colleton County real estate agents, and research home values in Colleton County, SC. Homes.com has everything you need but the house keys.