Buying a home in De Soto, Missouri does not have to be difficult - Homes.com makes home buying a breeze. With 288 homes for sale in De Soto, Missouri, you can search by price, bedrooms, neighborhood, and even by property type. Search De Soto homes for sale, foreclosures, MLS listings, and more. Make an informed decision with De Soto school data, neighborhood information, find De Soto real estate agents, and research home values in De Soto, MO. Homes.com has everything you need but the house keys.