Buying a home in O Brien, Florida does not have to be difficult - Homes.com makes home buying a breeze. With 68 homes for sale in O Brien, Florida, you can search by price, bedrooms, neighborhood, and even by property type. Search O Brien homes for sale, foreclosures, MLS listings, and more. Make an informed decision with O Brien school data, neighborhood information, find O Brien real estate agents, and research home values in O Brien, FL. Homes.com has everything you need but the house keys.