Buying a home in Pamplico, South Carolina does not have to be difficult - Homes.com makes home buying a breeze. With 18 homes for sale in Pamplico, South Carolina, you can search by price, bedrooms, neighborhood, and even by property type. Search Pamplico homes for sale, foreclosures, MLS listings, and more. Make an informed decision with Pamplico school data, neighborhood information, find Pamplico real estate agents, and research home values in Pamplico, SC. Homes.com has everything you need but the house keys.