Buying a home in Pickens County, South Carolina doesn't have to be difficult - Homes.com makes home buying a breeze. With 1,717 homes for sale in Pickens County, South Carolina, you can search by price, bedrooms, neighborhood, and even by property type. Search Pickens County homes for sale, foreclosures, MLS listings, and more. Make an informed decision with Pickens County school data, neighborhood information, find Pickens County real estate agents, and research home values in Pickens County, SC. Homes.com has everything you need but the house keys.