Buying a home in Pickens, South Carolina does not have to be difficult - Homes.com makes home buying a breeze. With 316 homes for sale in Pickens, South Carolina, you can search by price, bedrooms, neighborhood, and even by property type. Search Pickens homes for sale, foreclosures, MLS listings, and more. Make an informed decision with Pickens school data, neighborhood information, find Pickens real estate agents, and research home values in Pickens, SC. Homes.com has everything you need but the house keys.