Lafayette County FL Homes for Sale

• 

  

  

  /32

  $299,000

  • 3 Beds
  • 2 Baths
  • 1,740 Sq Ft

  755 NW County Road 260, Mayo, FL 32066

  3-bedroom, 2-bath mobile home on 5.19 acres in Mayo, FL. The home offers a functional layout with a primary bedroom and private bath, plus two additional bedrooms. The property provides ample space for animals, gardening, or future use. Located in a quiet rural area with easy access to town amenities. Suitable for full-time living or investment.

  Andrew Poole POOLE REALTY INC.

  755 NW County Road 260, Mayo, FL 32066
• 

  

  

  /61

  $420,000

  • 3 Beds
  • 2 Baths
  • 1,776 Sq Ft

  492 NE Northwood Dr, Mayo, FL 32066

  Experience the allure of this impeccably maintained and beautifully updated 3-bedroom, 2-bath home nestled in the highly sought-after Northwood Acres subdivision! This delightful split-plan residence features luxurious waterproof vinyl plank flooring that flows seamlessly throughout the home. With a brand-new roof and a fresh coat of exterior paint, this home is ready for you to move right in.

  Elizabeth Phillips DANIEL CRAPPS AGENCY, INC

  492 NE Northwood Dr, Mayo, FL 32066
• 

  

  

  /42

  $369,900

  • 3 Beds
  • 2 Baths
  • 1,700 Sq Ft

  1339 E Main St, Mayo, FL 32066

  Completely updated ranch-style home offering the perfect blend of modern comfort and timeless character. Updated flooring runs throughout, complemented by a beautifully refreshed kitchen featuring new cabinetry, updated appliances, and an eat-in island ideal for gathering. The oversized primary suite is a true retreat, complete with a stunningly updated primary bath showcasing his-and-her

  Chelsea Morgan Focus Real Estate Group, Inc.

  1339 E Main St, Mayo, FL 32066
• 

  

  

  /21

  $120,000

  • 3 Beds
  • 2 Baths
  • 1,815 Sq Ft

  278 N Fletcher Ave, Mayo, FL 32066

  Investor Alert!! This 1,815 square foot, three-bedroom, two-bathroom fix-and-flip home is located on .48 acres in downtown Mayo, FL. This home features a metal roof, carport, wood floors, and tiled bathroom. With some TLC, this home could be a great investment. Call today to schedule a showing!!

  Celia Wetzel LIVE OAK REALTY INC

  278 N Fletcher Ave, Mayo, FL 32066
• 

  

  

  /27

  $359,000

  • 3 Beds
  • 2 Baths
  • 1,536 Sq Ft

  1564 State Road 349, Branford, FL 32008

  One or more photo(s) has been virtually staged. Beautifully updated brick home offering 3 bedrooms, 2 bathrooms, plus a dedicated office or flex space, all set on a peaceful 6-acre property. The home underwent a complete remodel in 2025 featuring brand-new upgrades throughout, including a metal roof, energy-efficient windows, HVAC system, appliances, luxury vinyl plank flooring, custom cabinetry,

  Daniel Crapps DANIEL CRAPPS AGENCY, INC.

  1564 State Road 349, Branford, FL 32008
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  /26

  $85,000

  • 3 Beds
  • 2 Baths
  • 1,320 Sq Ft

  258 NE Riverside Blvd, Mayo, FL 32066

  *Multiple Offers received - Highest and Best due January 30th, by 2 pm est.* Located in Lafayette County, just across the river, is where you will find this 3-bedroom, 2-bath DWMH. Sitting on 1.92 acres (two lots), the property provides plenty of room to spread out. Inside offers a split floor plan complete with a fireplace in the living room. With a functional layout, this property presents an

  

  Mindy Wilkison

  POOLE REALTY INC.

  (386) 284-3492

  258 NE Riverside Blvd, Mayo, FL 32066
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  /76

  $1,499,998

  • Land
  • 93.87 Acres
  • $15,980 per Acre

  1083 NE Old Bridge Rd, Mayo, FL 32066

  Discover this extraordinary 93.87-acre recreational retreat nestled along the enchanting Suwannee River. Relax on the inviting porch of the brand-new tiny home, which comfortably accommodates up to eight guests and offers breathtaking views of the river. With its open layout and a fully equipped kitchen featuring gleaming stainless steel appliances, you'll feel right at home! For those needing

  Elizabeth Phillips DANIEL CRAPPS AGENCY, INC

  1083 NE Old Bridge Rd, Mayo, FL 32066
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  /67

  $399,000

  • 3 Beds
  • 2 Baths
  • 1,680 Sq Ft

  188 NW Lofton Rd, Mayo, FL 32066

  This three-bedroom, two-bath site-built home offers 1,680 square feet of living space and was built in 2002. It features a functional floor plan suited for full-time residence, homesteading, or rural living. Recent updates include a brand-new roof, along with the custom wood cabinetry, an eat-in kitchen, and spacious bedrooms... this one checks all the boxes! The property includes a 28x36

  Candice Land United Country Smith & Associates

  188 NW Lofton Rd, Mayo, FL 32066
• 

  

  /27

  $359,000

  • 3 Beds
  • 2 Baths
  • 1,536 Sq Ft

  1564 S Sr-349 (6 Ac), Branford, FL 32008

  Beautifully updated brick home offering 3 bedrooms, 2 bathrooms, plus a dedicated office or flex space, all set on a peaceful 6-acre property. The home underwent a complete remodel in 2025 featuring brand-new upgrades throughout, including a metal roof, energy-efficient windows, HVAC system, appliances, luxury vinyl plank flooring, custom cabinetry, granite countertops, a spacious eat-in island,

  Renee Tillman DANIEL CRAPPS AGENCY, INC

  1564 S Sr-349 (6 Ac), Branford, FL 32008
• 

  

  /3

  $29,900

  • Land
  • 1.25 Acres
  • $23,920 per Acre

  xxx Eral Southeast Blvd, Branford, FL 32008

  Private 1.25-acre cleared lot located in Branford, FL, just across the street from the Suwannee River. This flat parcel sits at the corner of a quiet dirt road, offering easy access and a peaceful, rural setting. The property is mostly cleared, making it a great opportunity for a future homesite, recreational use, or land investment. Owner believes there may be an abandoned well on the property;

  Lucretia Thomas Thomas Acq & Prop Spec

  xxx Eral Southeast Blvd, Branford, FL 32008
• 

  /2

  $24,900

  • Land
  • 2.88 Acres
  • $8,646 per Acre

  xxx SE Earl Blvd, Branford, FL 32008

  Wooded lot for sale in the Brandon area, located directly across the street from the scenic Suwannee River. This peaceful parcel offers a natural, tree-covered setting on a quiet dirt road, providing privacy and a true Old-Florida feel. Enjoy close proximity to the river for boating, fishing, kayaking, and outdoor recreation without being directly on the water. The wooded landscape makes this

  Lucretia Thomas Thomas Acq & Prop Spec

  xxx SE Earl Blvd, Branford, FL 32008
• 

  

  /47

  $200,000

  • 2 Beds
  • 2 Baths
  • 840 Sq Ft

  396 NE Beverly Hills Dr, Mayo, FL 32066

  Tucked away in the heart of North Florida, this beautiful 2019, 2 bedroom / 2 bathroom mobile home offers the kind of peaceful Southern living that’s getting harder to find. In very good condition and move-in ready, this home welcomes you with a charming front porch and back porch, perfect for sweet tea mornings and quiet country evenings.Out back, you’ll find a fenced-in backyard that feels

  Heath Bootle LOKATION

  396 NE Beverly Hills Dr, Mayo, FL 32066
• 

  

  /26

  $469,900

  • 3 Beds
  • 3.5 Baths
  • 2,108 Sq Ft

  301 NE Ka-Di Ln, Branford, FL 32008

  Escape the noise and reclaim your independence on this pristine five-acre homestead where comfort meets total self-sufficiency. Surrounded by the quiet beauty of the Branford countryside, this property is a sanctuary designed for those who want to live off the land without sacrificing modern convenience. Fully fenced and ready for horses, cattle, or a sprawling organic garden, the grounds offer a

  Lyle Kastrati ENGEL & VOLKERS GAINESVILLE

  301 NE Ka-Di Ln, Branford, FL 32008
• 

  /2

  $20,000

  • Land
  • 0.58 Acre
  • $34,483 per Acre

  0 SW San Pedro Ave, Mayo, FL 32066

  Location! Location! Location! Beautiful parcel of land in Mayo, FL waiting for you to build your dream home. Please verify all information. Measurements are estimates. All offers are welcomed.

  Elizabeth Ganesh KELLER WILLIAMS SUBURBAN TAMPA

  0 SW San Pedro Ave, Mayo, FL 32066
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  /47

  $159,900

  • 2 Beds
  • 2 Baths
  • 651 Sq Ft

  786 SE Turkey, Mayo, FL 32066

  Registered RV campground with a move-in-ready 2BR/2BA home-ideal base for Steinhatchee fishing & scalloping or seasonal hunting. Set on quiet country acreage just south of Mayo and less than 3/4 of a mile off State Road 51, the cabin/home offers an open living area, full kitchen, two bedrooms, two baths, and practical storage. Two detached garages/workshops provide covered parking and gear space,

  Robert Mastrangelo Realty Hub

  786 SE Turkey, Mayo, FL 32066
• 

  

  /16

  $57,900

  • Land
  • 1.99 Acres
  • $29,095 per Acre

  LOT 6 Charles River Estate, Live Oak, FL 32060

  Prime riverfront location! Escape to the peace and tranquility of riverfront living! This gorgeous lot offers direct access to the river, perfect for kayaking, fishing, boating, or simply enjoying serene waterfront views every day. Mature trees and natural landscape offering privacy and shade. This lot is the deal spot for your dream home, cabin, or weekend getaway

  Donna Stormes POOLE REALTY INC.

  LOT 6 Charles River Estate, Live Oak, FL 32060
• 

  

  /5

  $42,800

  • Land
  • 0.95 Acre
  • $45,053 per Acre

  0 NW Fulton St, Day, FL 32066

  0.95 ACRE LOT IN DAY, FL FOR ONLY $42,800!!! SELLER FINANCING AVAILABLE PER REQUEST. VERY SENSIBLE TERMS......SELLER ALSO WILLING TO DO SITE WORK FOR AN ADDITIONAL PRICE DEPENDING ON THE AMOUNT OF WORK REQUESTED. CASH PRICE IS $40,000......if Seller financing not required!! Prior to the Hurricanes, this was an easy lot to walk. HOWEVER, now, many trees are down which make it difficult to

  

  Chan Perry

  WATSON REALTY CORP

  (386) 273-7939

  0 NW Fulton St, Day, FL 32066
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  /32

  $433,920

  • Land
  • 54.24 Acres
  • $8,000 per Acre

  423 NW Keystone Dr, Mayo, FL 32066

  This 54-acre, High and Dry, property in Lafayette County, Florida offers excellent frontage on three roads: County Road 251, Keystone Road, and Longitude Road. The diverse land includes 22 acres of hardwoods, 17 acres of pasture with scattered trees, and 15 acres of planted pines. There are producing pecan, pear, and orange trees on the property, offering a promising start for a mini farm or

  Ryan Walker Southern Land & Homes

  423 NW Keystone Dr, Mayo, FL 32066
• 

  

  /10

  $15,000

  • Land
  • 1.44 Acres
  • $10,417 per Acre

  0 NW Fox Run Trail Unit 107, Mayo, FL 32066

  Tucked away in the heart of Old Florida, this 1.44-acre wooded lot offers a rare blend of privacy, nature, and river access. Surrounded by mature trees and alive with twinkling fireflies at night, this peaceful property is perfect for those looking to slow down and enjoy the outdoors. Enjoy community access to the historic Suwannee River, complete with a boat ramp just steps away—ideal for

  Wesley Lodyga EXP REALTY LLC

  0 NW Fox Run Trail Unit 107, Mayo, FL 32066
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  /68

  $875,000

  • 3 Beds
  • 2 Baths
  • 1,912 Sq Ft

  306 NE Castagna Ln, Mayo, FL 32066

  Escape to your own private nature retreat with this stunning 2,102 sq ft log cabin on 19.61 fully fenced and gated acres, located just one block from the world-renowned Suwannee River with a public boat ramp. This 3bR/2Ba home offers the perfect blend of rustic elegance, privacy, & convenience only 15 minutes from Live Oak & Branford. The home features warm wood interiors, generous living areas,

  

  Laura Nettles

  Pointer Properties

  (386) 832-1357

  306 NE Castagna Ln, Mayo, FL 32066
• 

  

  /20

  $775,000

  • Land
  • 59.01 Acres
  • $13,133 per Acre

  625 NE Holly Rd, O'Brien, FL 32071

  Country living at its best on this stunning 59-acre tract along the Suwannee River in Branford. This expansive property offers endless possibilities—build your dream home, create a private weekend getaway, or enjoy the land for hunting and recreation. With river access at nearby boat ramp for fishing and boating and close proximity to natural springs, this property is perfect for outdoor

  Dewey Hatcher Hatcher Realty Services, Inc. Steinhatchee

  625 NE Holly Rd, O'Brien, FL 32071
• 

  

  /23

  $775,000

  • Land
  • 59.01 Acres
  • $13,133 per Acre

  625 NE Holly Rd, Bradenton, FL 32008

  Country living at its best on this stunning 59-acre tract along the Suwannee River in Branford. This expansive property offers endless possibilities—build your dream home, create a private weekend getaway, or enjoy the land for hunting and recreation. With river access at nearby boat ramp for fishing and boating and close proximity to natural springs, this property is perfect for outdoor

  Dewey Hatcher Hatcher Realty Services, Inc. Steinhatchee

  625 NE Holly Rd, Bradenton, FL 32008
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  /7

  $150,000

  • Land
  • 20 Acres
  • $7,500 per Acre

  TBD SE Dad Waldron Ln, Mayo, FL 32066

  If you are looking for 20 acres off the beaten path to get away from people in a quiet country setting, you have found it!! This property is a hidden gem! 50% pasture and 50% trees/hardwoods so it is the perfect mix of trees and field for a homesite, farm, cows, sheep, or whatever you choose. Looking for a property to hunt or just watch & enjoy deer and turkeys? This one has got them!! There are

  

  Chan Perry

  WATSON REALTY CORP

  (386) 703-3278

  TBD SE Dad Waldron Ln, Mayo, FL 32066
• 

  

  /3

  $38,900

  • Land
  • 1.72 Acres
  • $22,616 per Acre

  X Earl Southeast Blvd, Branford, FL 32008

  Beautiful 1.72-acre riverfront lot with approximately 150 feet of frontage on the Suwannee River. This natural, wooded parcel offers a peaceful setting ideal for recreational use, fishing, kayaking, camping, or enjoying Florida’s Old-Florida river lifestyle. The property is located on a quiet dirt road, providing privacy and a true escape from the hustle and bustle. The lot is low and wet, making

  Lucretia Thomas Thomas Acq & Prop Spec

  X Earl Southeast Blvd, Branford, FL 32008
• 

  /2

  $19,950

  • Land
  • 1 Acre
  • $19,950 per Acre

  Mayo, FL SW Doe Rd, Mayo, FL 32066

  Location Location, Location, This beautifully wooded lot is 1 full acre of land. The perfect location to build the home of your dreams here.

  Paul Weathersby Land's End Property Group LLC

  Mayo, FL SW Doe Rd, Mayo, FL 32066
• 

  

  /18

  $125,000

  • Land
  • 20 Acres
  • $6,250 per Acre

  1032 SW Van Buren Rd, Mayo, FL 32066

  Explore the possibilities with this 20-acre parcel located just a couple of miles south of the Town of Mayo. This beautifully wooded property features an impressive mix of mature timber, hardwoods, oak trees, and natural underbrush, creating the ideal habitat for abundant wildlife. A natural pond adds to the property’s appeal, providing a reliable water source for deer, turkey, and other native

  Chelsea Morgan Focus Real Estate Group, Inc.

  1032 SW Van Buren Rd, Mayo, FL 32066
• 

  

  /44

  $2,551,150

  • Land
  • 728.9 Acres
  • $3,500 per Acre

  5150 Cr 405, Branford, FL 32008

  728.90 acres recreational property located in Lafayette County, FLApprox. 90 miles to Jacksonville; approx. 8 miles to Branford; approx. 150 miles to Orlando; approx. 170 miles to Tampa4/10ths of a mile frontage on Hwy 405Approx. 9/10ths of a mile of paved drivewayTwo small ponds, along with several cypress ponds providing excellent natural water fowl habitatWild Quail

  Walter Hatchett Jon Kohler & Associates

  5150 Cr 405, Branford, FL 32008
• 

  

  /65

  $3,220,000

  • Land
  • 322 Acres
  • $10,000 per Acre

  8619 E US 27, Mayo, FL 32066

  322 ACRES OF FARM LAND WITH BUILDINGS FOR $10,000.00/AC. Ready to start a farm? Cropland or pasture for animals. In RE, the old saying...."LOCATION, LOCATION, LOCATION!!!!". While farming this property, or leasing, the value will continue to appreciate for multiple reasons. This property has over 1.8 miles of US-27 frontage. 2 commercial wells for irrigation on the property. There is one 10"

  

  Chan Perry

  WATSON REALTY CORP

  (386) 388-6833

  8619 E US 27, Mayo, FL 32066
• 

  

  /6

  $140,000

  • Land
  • 20 Acres
  • $7,000 per Acre

  00 SE Walter Henderson Rd, Mayo, FL 32066

  If you're looking for 20 acres off the beaten path to get away from people in a quiet country setting, you have found it! This property is a hidden gem! 80% pasture and 20% hammock so it's the perfect mix of trees and field for a homesite or a place to run cows, goats, sheep,or whatever your heart desires. There are no deed restrictions on this parcel. This land is Flood zone X. The southern most

  

  Chan Perry

  WATSON REALTY CORP

  (386) 361-7525

  00 SE Walter Henderson Rd, Mayo, FL 32066
• 

  

  /6

  $42,000

  • Land

  TBD Lot 21 3-River Estat, Branford, FL 32008

  BOAT RAMP LESS THAN A MILE AWAY, AS PICUTRED. VERY NICE LOCATION IN A RIVER COMMUNITY.

  Marisol Brown TRINITY ROSE REALTY, INC

  TBD Lot 21 3-River Estat, Branford, FL 32008
• 

  

  /45

  $2,803,100

  • Land
  • 280.31 Acres
  • $10,000 per Acre

  8619 US Highway 27, Mayo, FL 32066

  280 ACRES OF FARM-LAND WITH hot dipped galvanized columns BUILDING FOR SALE IN LAFAYETTE COUNTY!!! Ready to start a farm? Come to one of the most Ag-friendly areas in the state of FL....Cropland, pastures for cows, horses, goats, or you can have any type of ranch, the possibilities are endless. This property has over 1.8 miles of US -27 frontage! 2 commercial wells for irrigation on the property.

  

  Chan Perry

  WATSON REALTY CORP

  (386) 359-2330

  8619 US Highway 27, Mayo, FL 32066
• 

  

  /4

  $65,000

  • Land
  • 1.17 Acres
  • $55,556 per Acre

  0 SE Oak Tree Rd, Branford, FL 32066

  LAKEFRONT LOT – 1.17 Acres on Pickett Lake Rare opportunity to own one of the few remaining vacant lakefront lots on the pristine and peaceful Pickett Lake in Lafayette County. This beautiful 1.17-acre parcel is perfectly situated on a quiet dead-end road, offering privacy, serenity, and stunning water views. The lot was cleared approximately five years ago and now just needs a bit of TLC to

  

  Karen Odom

  Hometown Realty of North Fl. Inc.

  (386) 356-7097

  0 SE Oak Tree Rd, Branford, FL 32066
• 

  

  /72

  $350,000

  • 5 Beds
  • 3 Baths
  • 2,552 Sq Ft

  112 NE Rowan Rd, Mayo, FL 32066

  Situated on 4.2 acres in Lafayette County, this two-story home offers five bedrooms, three bathrooms, and a functional layout designed for a variety of living needs. The property spans three road frontages—US Highway 27, NE Rowan Road, and NE Rosemary Way—and features established landscaping with large live oaks, original flowering plants, and irrigated garden areas.The first floor includes a

  Candice Land United Country Smith & Associates

  112 NE Rowan Rd, Mayo, FL 32066
• 

  

  /53

  $899,900

  • 3 Beds
  • 3 Baths
  • 2,273 Sq Ft

  536 SE Lakeview Dr, Branford, FL 32008

  Upscale lakefront living in beautiful North Central Florida! This stunning 2,200+ sq ft home sits on 8.68 acres just minutes from Branford and the crystal-clear springs of the Suwannee River. Designed with style and comfort in mind, the home features bamboo flooring, vaulted ceilings, and an open, light-filled floor plan perfect for entertaining or relaxing. The spacious kitchen is a chef’s

  Michael DeGeorge POOLE REALTY INC.

  536 SE Lakeview Dr, Branford, FL 32008
• 

  

  /16

  $59,900

  • Land
  • 2.8 Acres
  • $21,393 per Acre

  TBD SE Oak Tree Rd, Branford, FL 32066

  Are you ready for a getaway spot or a new place to call home? Located in the heart of North central Florida surrounded by beautiful natural lakes. This property offers a natural mixture of hard woods. The property is ready to be cleared and make your own prefect spot. Great location for all your water sports and outdoor activities. Get away from the hustle and bustle and make this property yours.

  Gregory Anderson COUNTRY RIVERS REALTY LLC

  TBD SE Oak Tree Rd, Branford, FL 32066
• 

  

  /44

  $435,000

  • 2 Beds
  • 2 Baths
  • 1,200 Sq Ft

  565 NE Marion Rd, Mayo, FL 32066

  Escape to your own private oasis on the beautiful Suwannee River! This one-of-a-kind cedar shake home is truly unique, surrounded by lush landscaping and multiple decks designed to maximize your riverfront views. Relax and unwind as you watch wildlife pass by, or head down to your private floating boat dock and double jet ski dock for endless days on the water. Inside, you’ll find a bright,

  Kellie Shirah POOLE REALTY INC.

  565 NE Marion Rd, Mayo, FL 32066
• 

  

  /43

  $325,000

  • 3 Beds
  • 2 Baths
  • 1,948 Sq Ft

  1476 SW County Road 300, Mayo, FL 32066

  Welcome to this custom-built home nestled on one acre of partially fenced, beautifully landscaped property with paved road access just minutes from the charming town of Mayo, FL. With no deed restrictions or HOA, you’ll enjoy the freedom to live as you please. A brand-new roof, attached garage, and large storage shed provide both convenience and peace of mind. The open patio sets the stage for

  Chelsea Morgan Focus Real Estate Group, Inc.

  1476 SW County Road 300, Mayo, FL 32066
• 

  

  /31

  $229,000

  • 2 Beds
  • 2 Baths
  • 960 Sq Ft

  196 Leslie Ln, Perry, FL 32348

  Discover your slice of peaceful North Florida living at this charming 2-bedroom, 2-bath cottage located in the quiet gated Keaton Beach Ridge HOA community — just minutes from the Keaton Beach boat ramp with full Gulf access and less than 20 minutes south of Perry. This high and dry .50 acre property offers peace of mind while being moments from the Gulf of Mexico. Built in 2009 as the original

  

  Hope Harvey Webb

  The American Dream

  (448) 413-6487

  196 Leslie Ln, Perry, FL 32348
• 

  

  /14

  $149,500

  • Land
  • 50 Acres
  • $2,990 per Acre

  0 W US Hwy 27 Unit 795887, Mayo, FL 32066

  50 acres of prime hunting land located just off Hwy 27 in Mayo! This expansive tract has recently had the timber harvested, making it a blank canvas ready for replanting or customizing to fit your needs. Surrounded by natural habitat and abundant with wildlife, this property is ideal for hunting, recreation, or future timber investment. With easy access from a main highway and plenty of space to

  Dewey Hatcher Hatcher Realty Services, Inc. Steinhatchee

  0 W US Hwy 27 Unit 795887, Mayo, FL 32066
• 

  

  /26

  $385,000

  • 4 Beds
  • 3 Baths
  • 2,424 Sq Ft

  235 SW Laura St, Mayo, FL 32066

  Beautifully Renovated 4-Sided Brick Home on a Full City Block! Don’t miss this stunning, move-in ready home that has been completely remodeled from top to bottom. Featuring 4 spacious bedrooms and 3 full bathrooms, this home offers modern upgrades while maintaining timeless charm. The inviting living area includes a must-see wood-burning fireplace, perfect for cozy evenings. A large bonus room

  Kristie Land DANIEL CRAPPS AGENCY, INC

  235 SW Laura St, Mayo, FL 32066

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