100 E Main St Florence, CO 81226

Own a piece of history in the heart of Florence, Colorado. Perfectly positioned on bustling Main Street, this charming historic mixed-use building offers exceptional visibility, steady foot traffic, and outstanding versatility for both investors and entrepreneurs. The main level features two retail or office storefronts making the spaces ideal for professional services, gallery space, café concepts, or other service-based businesses seeking strong exposure in a vibrant downtown setting. Upstairs, two beautifully updated modern apartments, each with its own balcony, blend contemporary comfort with classic architectural character. These well-appointed residential units provide excellent rental income or create the perfect live-work opportunity for an owner-operator who wants to run a business below and live just steps away. And, a small lot across the street comes with the purchase---parking for residents and employees! Whether you are expanding your investment portfolio or searching for a dynamic property that supports both lifestyle and income, this rare Main Street offering delivers flexibility, charm, and long-term potential in one of Southern Colorado’s most inviting historic communities.