Sikeston, MO Homes for Sale

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  $229,000 Coming Soon

  • 3 Beds
  • 2 Baths
  • 1,200 Sq Ft

  2163 E County Highway 450, Sikeston, MO 63801

  PICTURES COMING SOON! Welcome to this beautifully maintained one-owner home, thoughtfully designed and built with comfort in mind. Offering 3 bedrooms, 2 bathrooms, and approximately 1,200 sq ft of living space, this property blends an open, inviting layout with the peaceful feel of country living. Step inside to an open concept living room and kitchen, perfect for entertaining, family

  Christy Lawrence C. Lawrence Realty LLC

  2163 E County Highway 450, Sikeston, MO 63801
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  $65,900

  • 2 Beds
  • 1 Bath
  • 720 Sq Ft

  315 Virginia St, Sikeston, MO 63801

  Tara Roach EDGE Realty, ERA Powered

  315 Virginia St, Sikeston, MO 63801
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  /11

  $244,900

  • 3 Beds
  • 2 Baths
  • 1,592 Sq Ft

  8 Elizabeth Rd, Sikeston, MO 63801

  Just outside of Sikeston, this 3-bedroom, 2-bathroom home sits on a spacious half-acre lot and includes the adjoining half-acre vacant lot, giving you a full acre to enjoy. Relax on the front porch and take in breathtaking, unobstructed sunsets, or cozy up in the inviting family room/den with its warm gas fireplace. The property also features two additional outbuildings, perfect for storage,

  Kaci Self Epique Realty

  8 Elizabeth Rd, Sikeston, MO 63801
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  /4

  $500,000

  1209 Lawrence St, Sikeston, MO 63801

  Commercial land on a corner lot available for development in Sikeston's busiest retail area. 1.05 acres zoned light industrial is located directly across the street from Wal-Mart. Other major retailers located close by include JC Penney, Goodies, and Lowe's. Located in New Madrid county, Sikeston city limits.

  Tim Merideth Century 21 Premiere Realty

  1209 Lawrence St, Sikeston, MO 63801
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  $229,900

  • 3 Beds
  • 2 Baths
  • 1,489 Sq Ft

  806 Innsbruck Ln, Sikeston, MO 63801

  Open House 1/18/26 2-4pm. Virtually Move-in Ready. New appliances, roof, backyard fence. light fixtures, paint, new garage door and more. Just move in and unpack. This open concept home offers easy living with contemporary elegance. Come check it out. This home is centrally located to the main business part of town, within walking distance to Wing Elementary, and great for your daily walks.

  allen basham EXP Realty, LLC

  806 Innsbruck Ln, Sikeston, MO 63801
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  /2

  $48,000

  • 2 Beds
  • 1 Bath
  • 1,335 Sq Ft

  420 Malcolm Ave, Sikeston, MO 63801

  If you are looking for an investment property or a home that requires some TLC, this home is ready for your renovations. Priced to sell quickly, schedule your viewing today!

  Thomas Williams Century 21 Premiere Realty

  420 Malcolm Ave, Sikeston, MO 63801
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  $355,000

  • 3 Beds
  • 3 Baths
  • 6,536 Sq Ft

  901 Moore Ave, Sikeston, MO 63801

  Do you like both indoor and outdoor space? This is the one for you. This home includes a large sunroom with ceiling fans located on the back of the house overlooking gorgeous landscaping. There's also outdoor space on the composite deck if you'd like a little sun. This nice brick home is on a corner lot in Sikeston's north end. Inside, the kitchen was recently remodeled with a nice island and

  Tim Merideth Century 21 Premiere Realty

  901 Moore Ave, Sikeston, MO 63801
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  $295,000

  • 4 Beds
  • 2 Baths
  • 3,138 Sq Ft

  1601 N Main St, Sikeston, MO 63801

  Enjoy the best of country-calm living with the convenience of town in this beautifully updated home on 1.04 acres at the edge of town. Mature trees and a peaceful setting create the perfect backdrop for this spacious property. A 2-car attached garage pairs with a large detached garage that’s ideal for a third vehicle, workshop space, or all the toys and tools you’ve been wanting room for. Inside,

  Christy Lawrence C. Lawrence Realty LLC

  1601 N Main St, Sikeston, MO 63801
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  /3

  $42,500

  • Land
  • 0.34 Acre
  • $125,000 per Acre

  404 Secretariat, Sikeston, MO 63801

  Welcome to Saddleridge South, 2nd Addition! Located inside the city limits of Sikeston, these lots have utilities already ran to them and are ready for construction to begin. You can be the general contractor, or we can introduce you to some of the area's finest builders to work with. Covenants and restrictions were crafted to help protect property value and are available upon request. These are

  Tim Merideth Century 21 Premiere Realty

  404 Secretariat, Sikeston, MO 63801
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  $195,000

  • Land
  • 0.72 Acre
  • $270,833 per Acre

  116 Hospitality Dr, Sikeston, MO 63801

  Vacant, level lot. Not in the flood plain.

  Larry Lindsey Century 21 Premiere Realty

  116 Hospitality Dr, Sikeston, MO 63801
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  /2

  $15,000

  • Land
  • 0.24 Acre
  • $62,500 per Acre

  810 Cotton Ridge Dr, Sikeston, MO 63801

  This vacant residential lot is ready for you to build on, and priced to help you get started quickly. Covenants and restrictions are in place to help protect your investment. Located inside Sikeston City Limits. Additional Rooms: In Platted Subdv.

  Tim Merideth Century 21 Premiere Realty

  810 Cotton Ridge Dr, Sikeston, MO 63801
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  /26

  $239,900

  • 4 Beds
  • 2 Baths
  • 2,370 Sq Ft

  1704 State Highway Hh, Sikeston, MO 63801

  Looking for a large home outside city limits with a SHOP?!?! Check out this updated 4 bedroom, 2 bathroom home sitting on 1+/- acre lot. Home has been updated with windows, floor coverings, paint and so much more! This home offers plenty of space for a growing family. Inside you will find a eat-in kitchen with tile backsplash, under cabinet lighting, an island and a walk-in pantry! The kitchen

  Breanne Marks Ross Realty

  1704 State Highway Hh, Sikeston, MO 63801
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  /10

  $80,000

  • 2 Beds
  • 1 Bath
  • 884 Sq Ft

  516 Coleman St, Sikeston, MO 63801

  Welcome to 516 Coleman St. in Sikeston, a 2-bedroom home that combines classic charm with modern updates. Step inside to find some original hardwood floors that add warmth and character, complemented by new carpet in the bedrooms for a cozy touch. The fully remodeled bathroom features stylish finishes and a fresh, contemporary feel. This home offers comfortable living spaces, great natural light,

  Lauren DeWitt EDGE Realty, ERA Powered

  516 Coleman St, Sikeston, MO 63801
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  $400,000

  109 Stallcup Dr, Sikeston, MO 63801

  Over 2.5 acres of commercial property located in the heart of Sikeston's booming retail and hospitality area. Just a block from Wal-Mart Supercenter, 2 new hotels, shopping and restaurants, and a half mile to the intersection of US Highways 60 & 61. This is a premium location at an outstanding price.

  Tim Merideth Century 21 Premiere Realty

  109 Stallcup Dr, Sikeston, MO 63801
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  /28

  $239,900

  • 3 Beds
  • 2.5 Baths
  • 1,798 Sq Ft

  123 Holmes Dr, Sikeston, MO 63801

  This ALL BRICK home has many upgrades and is MOVE-IN-READY. The home has 3 bedrooms & 2 1/2 baths, one of the full bathrooms is a "Jack & Jill" style. The Heating & Cooling units were NEW in July 2025. ALL the Kitchen appliances stay with the home and were NEW in 2023. Backyard is completely fenced-in. Ask to see the seller's disclosure for all the upgrades and improvements. Average utility bill

  Mike Leible Century 21 Premiere Realty

  123 Holmes Dr, Sikeston, MO 63801
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  $265,000

  • 3 Beds
  • 2.5 Baths
  • 1,774 Sq Ft

  1811 State Highway Z, Sikeston, MO 63801

  This 3 bedroom, 2.5 bath home offers the perfect blend of space, privacy, and convenience. Situated on just over an acre +/- outside of city limits, you can enjoy peaceful country living while still being less than a 10 minute drive to town. The spacious layout provides comfortable living with thoughtful updates throughout. A standout feature is the shop, which offers over a thousand square feet

  Rachel Sitzes Poplar Bluff Realty Inc

  1811 State Highway Z, Sikeston, MO 63801
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  $99,400

  • 2 Beds
  • 1 Bath
  • 1,000 Sq Ft

  406 W Gladys St, Sikeston, MO 63801

  Step inside this beautifully remodeled 2-bedroom, 1-bath home that’s move-in ready and full of modern updates! Fresh interior and exterior paint give the home a crisp, inviting look, while the brand-new flooring throughout adds warmth and style.Outside, the freshly painted exterior provides excellent curb appeal, and the manageable yard makes maintenance a breeze.Whether you’re a

  Lawren McMullan EDGE Realty, ERA Powered

  406 W Gladys St, Sikeston, MO 63801
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  /2

  $90,000

  • 3 Beds
  • 1 Bath
  • 1,077 Sq Ft

  849 William St, Sikeston, MO 63801

  Enjoy entertaining in this 3-bedroom, 1-bath home with a spacious yard and separate dining room. Updates like the new dryer plug-in, baseboard heaters, fresh interior paint, kitchen cabinets, and sink add modern convenience while keeping maintenance low. Plus, the covered carport provides protected parking. Set up a showing today!

  Tasha Cardin EXP Realty, LLC

  849 William St, Sikeston, MO 63801
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  $299,900

  • 3 Beds
  • 2 Baths
  • 1,734 Sq Ft

  1205 Yosemite, Sikeston, MO 63801

  This well-maintained 3-bedroom, 2-bath home offers a thoughtful layout designed for everyday comfort and convenience, complemented by a modern, neutral color palette throughout. The laundry room is conveniently located just off the garage, making daily routines a breeze. The kitchen features granite countertops and stainless steel appliances, blending style with functionality. The primary suite

  Lynsey Perry Silverthorn Realty, LLC

  1205 Yosemite, Sikeston, MO 63801
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  /3

  $42,500

  • Land
  • 0.39 Acre
  • $108,974 per Acre

  419 Secretariat, Sikeston, MO 63801

  Welcome to Saddleridge South, 2nd Addition! Located inside the city limits of Sikeston, these lots have utilities already ran to them and are ready for construction to begin. You can be the general contractor, or we can introduce you to some of the area's finest builders to work with. Covenants and restrictions were crafted to help protect property value and are available upon request. These are

  Tim Merideth Century 21 Premiere Realty

  419 Secretariat, Sikeston, MO 63801
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  /2

  $47,000

  • 4 Beds
  • 2 Baths
  • 1,300 Sq Ft

  408 Carroll St, Sikeston, MO 63801

  If you are looking for an investment property or a home that requires some TLC, this home is ready for your renovations. Priced to sell quickly, schedule your viewing today!

  Thomas Williams Century 21 Premiere Realty

  408 Carroll St, Sikeston, MO 63801
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  $3,960,000

  0 Ables Rd, Sikeston, MO 63801

  Located on the northwest corner of I-55 and I-57 inside Sikeston City limits, this ground is in a prime location for commercial development. This property can be accessed via Ables Road or County Line Road. Owner will subdivide into smaller tracts. There is power, water and sewer available, all provided by Sikeston Board of Municipal Utilities.

  Tim Merideth Century 21 Premiere Realty

  0 Ables Rd, Sikeston, MO 63801
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  /2

  $69,900

  • 2 Beds
  • 1 Bath
  • 1,204 Sq Ft

  334 E Kathleen St, Sikeston, MO 63801

  Christina Essner EXP Realty, LLC

  334 E Kathleen St, Sikeston, MO 63801
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  $106,000

  • Land
  • 0.86 Acre
  • $123,256 per Acre

  120 Cypress Branch Rd, Sikeston, MO 63801

  Greenfield North will be a gated, fenced cul-de-sac community located inside the city limits of Sikeston, just off Highway 61. You'll experience the convenience of town combined with the calm of a quiet neighborhood. Enjoy a private, secure location for your custom home. The covenants and restrictions were designed to help preserve property values and maintain a safe, high-quality, and

  Tim Merideth Century 21 Premiere Realty

  120 Cypress Branch Rd, Sikeston, MO 63801
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  /3

  $42,500

  • Land
  • 0.35 Acre
  • $121,429 per Acre

  408 Secretariat, Sikeston, MO 63801

  Welcome to Saddleridge South, 2nd Addition! Located inside the city limits of Sikeston, these lots have utilities already ran to them and are ready for construction to begin. You can be the general contractor, or we can introduce you to some of the area's finest builders to work with. Covenants and restrictions were crafted to help protect property value and are available upon request. These are

  Tim Merideth Century 21 Premiere Realty

  408 Secretariat, Sikeston, MO 63801
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  $259,900

  • 3 Beds
  • 1.5 Baths
  • 1,782 Sq Ft

  109 Lynn St, Sikeston, MO 63801

  Welcome to 109 Lynn St. in Sikeston, located in the desirable Mini Farms subdivision - where space and comfort come together for family living. This 3-bedroom, 2-bathroom home offers two spacious living rooms, perfect for family movie nights, play areas, or hosting friends and relatives. Sitting on 1.62 acres, there is plenty of room for kids to play, pets to roam, and outdoor gatherings to

  Lauren DeWitt EDGE Realty, ERA Powered

  109 Lynn St, Sikeston, MO 63801
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  /3

  $42,500

  • Land
  • 0.33 Acre
  • $128,788 per Acre

  403 Secretariat, Sikeston, MO 63801

  Welcome to Saddleridge South, 2nd Addition! Located inside the city limits of Sikeston, these lots have utilities already ran to them and are ready for construction to begin. You can be the general contractor, or we can introduce you to some of the area's finest builders to work with. Covenants and restrictions were crafted to help protect property value and are available upon request. These are

  Tim Merideth Century 21 Premiere Realty

  403 Secretariat, Sikeston, MO 63801
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  /2

  $108,000

  • Land
  • 0.99 Acre
  • $109,091 per Acre

  110 Cypress Branch Rd, Sikeston, MO 63801

  Greenfield North will be a gated, fenced cul-de-sac community located inside the city limits of Sikeston, just off Highway 61. You'll experience the convenience of town combined with the calm of a quiet neighborhood. Enjoy a private, secure location for your custom home. The covenants and restrictions were designed to help preserve property values and maintain safe, high-quality, and comfortable

  Tim Merideth Century 21 Premiere Realty

  110 Cypress Branch Rd, Sikeston, MO 63801
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  $49,000

  • 2 Beds
  • 1 Bath
  • 976 Sq Ft

  115 William St, Sikeston, MO 63801

  Looking for a great investment opportunity. This home is it: nice size lot, detached shop/storage, a new roof in 2023, a new swing heat/cool unit and a few new windows. Home has original wood floors in living room and bedroom. Home needs to be redone in several of the rooms but definitely not a major overhaul. Make your appointment today and make this property your investment.

  Reida Kimes Century 21 Premiere Realty

  115 William St, Sikeston, MO 63801
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  $244,500

  • Land
  • 1.57 Acres
  • $155,732 per Acre

  1401 N Main St, Sikeston, MO 63801

  Located on Highway 61, on the northern edge of Sikeston City limits, this tract is situated on a high-traffic state route that connects Sikeston with the City of Sikeston Industrial Park and Sikeston campus of Southeast Missouri State University. It is adjacent to Greenbriar and Fairfield Subdivisions; two of the town's nice subdivisions. Zoning is C-1 Neighborhood Shopping District, which is for

  Tim Merideth Century 21 Premiere Realty

  1401 N Main St, Sikeston, MO 63801
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  /2

  $69,900

  • 2 Beds
  • 2 Baths
  • 1,008 Sq Ft

  118 N 3rd St, Sikeston, MO 63801

  Welcome to this 2-bedroom, 2-bath ranch home—a perfect choice for a starter home or someone looking to downsize! Enjoy the ease of single-level living with a functional layout and plenty of natural light throughout. The home includes a detached garage, offering extra storage or workspace potential. With its classic design and solid bones, this property is full of potential to make it your own.

  Christina Essner EXP Realty, LLC

  118 N 3rd St, Sikeston, MO 63801
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  /2

  $47,000

  • 3 Beds
  • 1 Bath
  • 1,309 Sq Ft

  1140 Ruth St, Sikeston, MO 63801

  If you are looking for an investment property or a home that requires some TLC, this home is ready for your renovations. Priced to sell quickly, schedule your viewing today!

  Thomas Williams Century 21 Premiere Realty

  1140 Ruth St, Sikeston, MO 63801
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  /2

  $15,000

  • Land
  • 0.2 Acre
  • $75,000 per Acre

  809 Bollweevil Blvd, Sikeston, MO 63801

  This vacant residential lot is ready for you to build on, and priced to help you get started quickly. Covenants and restrictions are in place to help protect your investment. Located inside Sikeston City Limits. Additional Rooms: In Platted Subdv.

  Tim Merideth Century 21 Premiere Realty

  809 Bollweevil Blvd, Sikeston, MO 63801
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  $169,900

  • 3 Beds
  • 1.5 Baths
  • 1,653 Sq Ft

  926 Crescent Dr, Sikeston, MO 63801

  This beautifully maintained all-brick hoe is nestled in a quiet, family-friendly neighborhood. It features 3 bedrooms, 1.5 baths, and a full basement with the potential for an additional bathroom. The interior boasts new laminate flooring throughout, and the roof was replaced in 2020, and the HVAC is 2 years old. Enjoy a spacious kitchen, with a double oven - perfect for cooking and entertaining

  Rene Church Century 21 Premiere Realty

  926 Crescent Dr, Sikeston, MO 63801
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  /2

  $59,900

  • 2 Beds
  • 1 Bath
  • 744 Sq Ft

  321 Benton St, Sikeston, MO 63801

  Investor Opportunity! This income-producing property offers solid potential with hardwood and tile floors throughout, combining durability with low-maintenance appeal. The fenced-in yard adds value for tenants seeking outdoor space, and the property's layout and location make it an attractive rental option. Whether you're expanding your portfolio or diving into your first investment, this is a

  Christina Essner EXP Realty, LLC

  321 Benton St, Sikeston, MO 63801
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  $188,900

  • 3 Beds
  • 2 Baths
  • 1,985 Sq Ft

  719 N West St, Sikeston, MO 63801

  Nice brick home with a family room added on the back. Wood burning fireplace. Huge walk in pantry. The bedrooms area ll good size. Master bath, unfinished basement perfect for storage.

  Ricki Ing Century 21 Ashland Realty

  719 N West St, Sikeston, MO 63801
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  $260,000 Open Sun 1PM - 3PM

  • 3 Beds
  • 1.5 Baths
  • 2,034 Sq Ft

  106 Holmes Dr, Sikeston, MO 63801

  Spacious, modern, updated, extremely well appointed. Enter into a large living room plus a cozy family room at the back. Lots of natural light thru out. large eat in kitchen with island, all kitchen appliances stay including convection/air fryer oven and 2 pantry cabinets.. Vinyl plank flooring with new carpet in two bedrooms. Electric insert in the wood fireplace, the owner has never burned wood

  Linda Essner Century 21 Ashland Realty

  106 Holmes Dr, Sikeston, MO 63801
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  /2

  $48,000

  • 3 Beds
  • 2 Baths
  • 1,120 Sq Ft

  1205 W Murray Ln, Sikeston, MO 63801

  If you are looking for an investment property or a home that requires some TLC, this home is ready for your renovations. Priced to sell quickly, schedule your viewing today!

  Thomas Williams Century 21 Premiere Realty

  1205 W Murray Ln, Sikeston, MO 63801
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  /23

  $240,000

  • 4 Beds
  • 2 Baths
  • 2,137 Sq Ft

  2093 E County Highway 450, Sikeston, MO 63801

  This TOTALLY REMODELED 4 bedroom 2 bathroom RURAL home sits on approximately 1.5 acres.All the NEW kitchen appliances stay with the home. The roof covering has been replaced and the Heating & Air units are NEW. Great opportunity to have a MOVE-IN READY home in the country.

  Mike Leible Century 21 Premiere Realty

  2093 E County Highway 450, Sikeston, MO 63801
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  /75

  $275,000

  • 3 Beds
  • 2 Baths
  • 1,295 Sq Ft

  511 S Kingshighway St, Sikeston, MO 63801

  Discover the perfect blend of timeless charm and contemporary luxury in this beautifully updated historical home. Featuring 3 spacious bedrooms, 2 full bathrooms, and an unfinished basement, this residence offers both character and comfort. Step inside to a light-filled interior adorned with gorgeous designer wallpaper, custom drapery, and thoughtful details that honor the home’s rich history.

  Lawren McMullan EDGE Realty, ERA Powered

  511 S Kingshighway St, Sikeston, MO 63801

Showing Results 41 - 80, Page 2 of 4