Defiance, MO Homes for Sale

Q: What are the most popular zip codes in Defiance, MO?

The most popular zip codes in Defiance, MO include 63341 , 63073 , 63348 , 63332 and 63069 .

/3
$199,900
- Land
- 3.45 Acres
- $57,942 per Acre
0 Defiance Rd Unit 22755774, Defiance, MO 63341

This expansive 3.45-acre lot is ideally situated in the heart of downtown Defiance, offering a rare combination of space and convenience. The property features a charming, rustic red barn that adds a touch of character and potential for various uses, from storage to creative projects. The ample size of the lot provides plenty of room for development, gardening, or outdoor activities. With its

MO Realty MO Realty

0 Defiance Rd Unit 22755774, Defiance, MO 63341
Explore Defiance
/13
$1,489,000 Coming Soon
- 5 Beds
- 3.5 Baths
- 4,660 Sq Ft
1275 Kohlers Ln, Defiance, MO 63341

An impressive brick & stone elevation highlights the remarkable curb appeal of this spectacular great room ranch on wooded 2+ ac grounds. Impressive hardwood foyer leads to private study with French doors, elegant dining room framed by arched entryways & stunning great room with floor-to-ceiling stone fireplace flanked by built-in bookcases & expansive wall of windows. Designer kitchen with

Teddy Johnlikes Coldwell Banker Realty - Gundaker

1275 Kohlers Ln, Defiance, MO 63341
/11
$1,499,000 Coming Soon
- 4 Beds
- 3.5 Baths
- 4,461 Sq Ft
115 Markham Trail Ln, Defiance, MO 63341

Looking for the perfect multi-generational home or private in-law suite with its own entrance? This custom-built Lombardo Ranch on 5.44 acres checks every box. Thoughtfully designed with high-end upgrades throughout, this home blends style, comfort, and function in every detail.On the main level, you’ll find a chef’s kitchen featuring white custom cabinetry, quartz countertops, a striking

Madison Lantz Berkshire Hathaway HomeServices Select Properties

115 Markham Trail Ln, Defiance, MO 63341
/98
$1,389,000 New Construction
- 5 Beds
- 5.5 Baths
- 5,504 Sq Ft
170 Blue Sky, Defiance, MO 63341

Brand new custom-built home on 3+ wooded acres in Kohler Estates subdivision. Features 4 bedrooms and 5 1/2 baths, a oversized 4 car garage with stair access to basement, a Great Room with a stone gas fireplace, with custom bookshelves, Gourmet kitchen offers custom cabinetry with quartz countertops, tile backsplash, and a complete appliance package, and walk-in pantry with custom shelving.

Chris Dawson Orenda Real Estate Services

170 Blue Sky, Defiance, MO 63341
/47
$1,250,000
- 5 Beds
- 4.5 Baths
- 4,852 Sq Ft
38 Hidden Vista Dr, Defiance, MO 63341

Set on 3 park-like acres, this traditional/craftsman style like-new home offers over 4,800 sf of living space with exceptional design, functionality and privacy. 9 ft ceilings and luxury vinyl plank flooring run throughout the main living areas, creating a substantially bright and cohesive feel from the moment you enter. Just off the front entry is a private office with glass French doors, ideal

Julie Burt Blondin Group, Inc

38 Hidden Vista Dr, Defiance, MO 63341
/62
$1,195,000 Coming Soon
- 5 Beds
- 4.5 Baths
- 5,045 Sq Ft
1199 August Lake Dr, Defiance, MO 63341

Spectacular brick & stone 1.5-Sty on wooded 3-acre lot in beautiful August Estates. Impressive 2-sty foyer leads to coffered dining room with wide bay window & arched entryway framed by architectural columns and stunning great room with dramatic wall of windows & granite fireplace. Designer kitchen with staggered white cabinetry, granite countertops, stainless steel appliances & 7’ center island

Teddy Johnlikes Coldwell Banker Realty - Gundaker

1199 August Lake Dr, Defiance, MO 63341
/3
$338,650
- Land
- 5.21 Acres
- $65,000 per Acre
440 Stones Throw Ct, Defiance, MO 63341

Welcome to Callaway Lake Estates, an exclusive luxury subdivision nestled in the serene countryside of unincorporated Saint Charles County, Missouri. This prestigious community offers 108 breathtaking lots, ranging from 5 to 15 acres, providing the perfect canvas for your custom dream home. With a minimum build requirement of 2,400 sq. ft. and architectural approval, each estate combines elegance

Stephen Kaiser Trophy Properties & Auction

440 Stones Throw Ct, Defiance, MO 63341
/4
$279,900
- Land
- 5 Acres
- $55,980 per Acre
5011 Lily Ridge, Defiance, MO 63341

Sunset Estates in St. Charles County MO. Four Luxurious home sites, on 5 acre lots. Located in the heart of Defiance and wine country. Bring your own builder/plans and build your dream home on one of these premium secluded, all wooded lots. Homesites are located on a private street with cul-de-sac. Homeowners will enjoy the peace and quiet, along with privacy. County water and high-speed

Bill McNair II First American Real Estate Co.

5011 Lily Ridge, Defiance, MO 63341
/4
$151,000
- Land
- 5.03 Acres
- $30,020 per Acre
180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341

Awesome lot available in a rural subdivision

Dan Lauderdale Lauderdale Realty

180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341
/4
$502,000
- Land
- 5.02 Acres
- $100,000 per Acre
60 Lakefront Ct, Defiance, MO 63341

Welcome to Lot #60 in Callaway Lake Estates, an exclusive luxury subdivision nestled in the serene countryside of unincorporated Saint Charles County, Missouri. This prestigious community offers 108 breathtaking lots, ranging from 5 to 15 acres, providing the perfect canvas for your custom dream home. With a minimum build requirement of 2,400 sq. ft. and architectural approval, each estate

Toni Dillon Trophy Properties & Auction

60 Lakefront Ct, Defiance, MO 63341
/8
$264,000
- Land
- 3.64 Acres
- $72,527 per Acre
0 Highway D Unit MIS25079698, Defiance, MO 63341

Discover the perfect place to bring your dream home to life! This beautiful 3.64-acre property located in unincorporated St. Charles County offers the freedom and flexibility you’ve been searching for—no subdivision restrictions and plenty of space to create exactly what you envision. Whether you're dreaming of a private estate, this land provides endless possibilities. Enjoy peaceful country

Ashley Bahr Coldwell Banker Realty - Gundaker

0 Highway D Unit MIS25079698, Defiance, MO 63341
/30
$949,900
- 4 Beds
- 5 Baths
- 2,436 Sq Ft
4075 Highway D, Defiance, MO 63341

NOT IN A SUBDIVISION, NO INDENTURES OR RESTRICTIONS!!!! NEW ROOF.This is a must see!!! This beautifully updated, well maintained home with 3 beds, (3) full (2) 1/2 baths is on 10 flat acres. Primary bedroom has a bay window, separate shower/jacuzzi tub. Family room has a wood burning fireplace. Relax on the covered porch that overlooks a water feature and the lake. Kitchen has granite

John Shaw Tom Shaw, REALTORS

4075 Highway D, Defiance, MO 63341
/9
$151,000
- Land
- 5.05 Acres
- $29,901 per Acre
130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341

Great Building Lot. Schedule an appointment and view this property today.

Dan Lauderdale Lauderdale Realty

130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341
/2
$152,000
- Land
- 5.06 Acres
- $30,040 per Acre
120 Steeple Point Dr Lot #13 Dr, Defiance, MO 63341

Another Great Lot in the Steeple Point Subdivision. Schedule your appointment to view today.

Dan Lauderdale Lauderdale Realty

120 Steeple Point Dr Lot #13 Dr, Defiance, MO 63341
/4
$319,900
- Land
- 5 Acres
- $63,980 per Acre
5000 Lily Ridge, Defiance, MO 63341

Sunset Estates in St. Charles County MO. Four Luxurious home sites, on 5 acre lots. Located in the heart of Defiance and wine country. Bring your own builder/plans and build your dream home on one of these premium secluded, all wooded lots. Homesites are located on a private street with cul-de-sac. Homeowners will enjoy the peace and quiet, along with privacy. County water and high-speed

Bill McNair II First American Real Estate Co.

5000 Lily Ridge, Defiance, MO 63341
/2
$238,900
- Land
- 8.89 Acres
- $26,873 per Acre
110 Steeple Point Dr Lot # 14 Dr, Defiance, MO 63341

WOW, nearly 9 acres for under $250,000. Schedule an appointment and view this lot today.

Dan Lauderdale Lauderdale Realty

110 Steeple Point Dr Lot # 14 Dr, Defiance, MO 63341
/19
$325,000
- Land
- 5.03 Acres
- $64,612 per Acre
3077 S Missouri 94, Defiance, MO 63341

5.03 acre homesite with exceptional Missouri River Valley views just outside the heart of Defiance. This scenic property offers a rare opportunity to build your home where the landscape opens to sweeping countryside views and beautiful sunrise exposure over the valley. The property features a PRIVATE Lane with direct access to Hwy 94, providing convenient access while maintaining a peaceful

Sherry Ruyle Meyer & Company Real Estate

3077 S Missouri 94, Defiance, MO 63341
/3
$412,800
- Land
- 6.88 Acres
- $60,000 per Acre
48 Watershed Ct, Defiance, MO 63341

Welcome to Callaway Lake Estates, an exclusive luxury subdivision nestled in the serene countryside of unincorporated Saint Charles County, Missouri. This prestigious community offers 108 breathtaking lots, ranging from 5 to 15 acres, providing the perfect canvas for your custom dream home. With a minimum build requirement of 2,400 sq. ft. and architectural approval, each estate combines elegance

Stephen Kaiser Trophy Properties & Auction

48 Watershed Ct, Defiance, MO 63341
/5
$279,900
- Land
- 5 Acres
- $55,980 per Acre
5001 Lily Ridge Ct, Defiance, MO 63341

Four Luxurious home sites, on 5 acre lots. Sunset Estates in St. Charles County MO. Located in the heart of Defiance and wine country. Bring your own builder/plans and build your dream home on one of these premium secluded, all wooded lots. Homesites are located on a private street with cul-de-sac. Homeowners will enjoy the peace and quiet, along with privacy. County water and high-speed

Bill McNair II First American Real Estate Co.

5001 Lily Ridge Ct, Defiance, MO 63341
/4
$154,000
- Land
- 5.13 Acres
- $30,019 per Acre
150 Steeple Point Dr Lot #10 Dr, Defiance, MO 63341

Gorgeous Lot in Steeple Point. Great views and quite living.

Dan Lauderdale Lauderdale Realty

150 Steeple Point Dr Lot #10 Dr, Defiance, MO 63341
/3
$325,000
- Land
- 5 Acres
- $65,000 per Acre
521 Callaway Estates Dr, Defiance, MO 63341

Welcome to Callaway Lake Estates, an exclusive luxury subdivision nestled in the serene countryside of unincorporated Saint Charles County, Missouri. This prestigious community offers 108 breathtaking lots, ranging from 5 to 15 acres, providing the perfect canvas for your custom dream home. With a minimum build requirement of 2,400 sq. ft. and architectural approval, each estate combines elegance

Stephen Kaiser Trophy Properties & Auction

521 Callaway Estates Dr, Defiance, MO 63341
/47
$679,900 Open Sun 2PM - 4PM
- 4 Beds
- 2.5 Baths
- 2,556 Sq Ft
1330 Lake Hollow Dr, Defiance, MO 63341

Enjoy the serenity of your own private retreat, surrounded by trees and nature while still being just minutes from shopping, dining, and entertainment. Inside, the stunning kitchen is a true showpiece—featuring quartz countertops, cherry cabinetry, stainless steel appliances, a massive island, and a spacious walk-in pantry. The main level shines with new 5” wide wood-plank luxury vinyl flooring,

Suzanne Matyiko ReeceNichols Real Estate

1330 Lake Hollow Dr, Defiance, MO 63341
/4
$325,000
- Land
- 5 Acres
- $65,000 per Acre
525 Callaway Estates Dr, Defiance, MO 63341

Welcome to Callaway Lake Estates...Lot #5, an exclusive luxury subdivision nestled in the serene countryside of unincorporated Saint Charles County, Missouri. This prestigious community offers 108 breathtaking lots, ranging from 5 to 15 acres, providing the perfect canvas for your custom dream home. With a minimum build requirement of 2,400 sq. ft. and architectural approval, each estate combines

Toni Dillon Trophy Properties & Auction

525 Callaway Estates Dr, Defiance, MO 63341
/11
$495,000
- Land
- 9.05 Acres
- $54,696 per Acre
2461 Highway F, Defiance, MO 63341

9.05 acres in the Francis Howell School District offering a versatile opportunity for farming, recreation, or future building. The property is primarily level and features an established well operated by a solar pump with 5 frost free spigots throughout the southeastern side of the property, making it ideal for gardens, orchards or hobby farming. A private gravel driveway has been added on the

Julie Burt Blondin Group, Inc

2461 Highway F, Defiance, MO 63341
/4
$420,800
- Land
- 5.26 Acres
- $80,000 per Acre
449 Stones Throw Ct, Defiance, MO 63341

Welcome to Callaway Lake Estates, an exclusive luxury subdivision nestled in the serene countryside of unincorporated Saint Charles County, Missouri. This prestigious community offers 108 breathtaking lots, ranging from 5 to 15 acres, providing the perfect canvas for your custom dream home. With a minimum build requirement of 2,400 sq. ft. and architectural approval, each estate combines elegance

Toni Dillon Trophy Properties & Auction

449 Stones Throw Ct, Defiance, MO 63341
/80
$739,900 Open Sun 1PM - 3PM
- 4 Beds
- 3 Baths
- 4,245 Sq Ft
762 Lake Valley Dr, Defiance, MO 63341

Welcome to desirable Forest Lake Estates and your opportunity to own a beautiful custom built atrium ranch on a spectacular 3.42 acre wooded lot which includes a shared lake. Situated on a quiet cul-de-sac and graced with stunning curb appeal, this home has been meticulously maintained and has some amazing features including: elegant MUST SEE hardwood floors, custom millwork & trim,

Anthony Colón Fox & Riley Real Estate

762 Lake Valley Dr, Defiance, MO 63341
/51
$375,000
- 3 Beds
- 2 Baths
- 1,225 Sq Ft
2934 S Highway 94, Defiance, MO 63341

Refurbished 100-year-old historic home in the heart of Defiance wine country, offering rare character and flexible potential. This property is ideal for buyers seeking lifestyle, income opportunity, or a creative use rather than a traditional suburban layout. Completely updated while preserving original charm. Currently zoned residential and well-suited for short-term rental use (buyer to

Chris Neskar Compass Realty Group

2934 S Highway 94, Defiance, MO 63341
/91
$799,000
- 5 Beds
- 3.5 Baths
- 4,564 Sq Ft
2 Woodridge Dr, Defiance, MO 63341

Spacious ranch home on 3 acres in one of the most beautiful settings in St. Charles County. Welcome home to picturesque rustic hardwood floors, a spacious country kitchen, large windows, vaulted ceilings, and TWO cozy fireplaces. The front, back, and side yards boast lovely mature trees placed perfectly to enhance the view and privacy. The pool (complete with a waterfall, salt water, and heater)

Kathleen Helbig EXP Realty, LLC

2 Woodridge Dr, Defiance, MO 63341
/64
$850,000 Open Sun 2PM - 4PM
- 5 Beds
- 5 Baths
- 5,057 Sq Ft
1354 Lake Hollow Dr, Defiance, MO 63341

Set on 3 beautifully landscaped acres surrounded by mature trees, this exceptional story-and-a-half residence blends timeless architecture with the warm sophistication of a Ralph Lauren–inspired interior. Rich wood floors, custom millwork, and thoughtfully designed spaces create a home that feels both refined and welcoming. A dramatic two-story foyer makes an unforgettable first impression,

Suzanne Matyiko ReeceNichols Real Estate

1354 Lake Hollow Dr, Defiance, MO 63341
/2
$290,000
- Land
- 10.72 Acres
- $27,052 per Acre
190 Steeple Point Dr Lot #6 Dr, Defiance, MO 63341

Great home site in a rural setting.

Dan Lauderdale Lauderdale Realty

190 Steeple Point Dr Lot #6 Dr, Defiance, MO 63341
/23
$300,000
- Land
- 5.01 Acres
- $59,907 per Acre
404 Stones Throw Ct, Defiance, MO 63341

Beautiful 5-acre building lot located in the highly sought-after gated community of Callaway Lake Estates! Bring your builder and design the home of your dreams while adhering to community building restrictions that help preserve the neighborhood’s character and value. Enjoy access to the 168-acre Callaway Lake, perfect for fishing, boating, and relaxing by the water. This prime lot is within the

Tim Phillips MO Realty

404 Stones Throw Ct, Defiance, MO 63341
/70
$2,775,000
- 3 Beds
- 4.5 Baths
- 4,037 Sq Ft
353 Callaway Ridge Dr, Defiance, MO 63341

Experience the ultimate in privacy and natural beauty with this stunning custom waterfront property nestled on 37+ mostly wooded acres fronting the serene waters of Callaway Valley Lake. Crafted with exceptional attention to detail, this one-of-a-kind property showcases rich woodwork and impeccable craftsmanship throughout. Highlighted by a grand wood-paneled ceiling with softly arched beams, and

Maureen Blondin Blondin Group, Inc

353 Callaway Ridge Dr, Defiance, MO 63341
/12
$155,000
- Land
- 5.17 Acres
- $29,981 per Acre
160 Steeple Point Dr Lot #9 Dr, Defiance, MO 63341

Dan Lauderdale Lauderdale Realty

160 Steeple Point Dr Lot #9 Dr, Defiance, MO 63341
/92
$795,000
- 5 Beds
- 3.5 Baths
- 4,814 Sq Ft
3780 Forest Meadow Dr, Defiance, MO 63341

Experience refined country living in this stunning 1.5-story estate nestled on a peaceful 3.43-acre lot. This 5-bedroom, 3.5-bath home combines timeless design, modern updates, and luxurious comfort throughout. The gourmet kitchen impresses with white cabinetry, gleaming quartz countertops, a large center island, and an inviting eat-in peninsula. A spacious walk-in pantry and a convenient wet bar

Emily Brophy MO Realty

3780 Forest Meadow Dr, Defiance, MO 63341

Missouri St. Charles County Defiance

Why Live in Defiance

Defiance, Missouri, is an unincorporated community in southwest St. Charles County, known for its expansive lots and rural charm. With a population of around 3,200, Defiance offers a blend of farms, vineyards and pastoral estates. Homes typically sit on lots of 5 acres or more, though 3-acre lots are also common. The Francis Howell School District serves the area, with students attending the highly rated Daniel Boone Elementary School, Francis Howell Middle School, and the newly relocated Francis Howell High School. Local attractions include the Defiance General Store on Highway 94, where residents can enjoy coffee, deli sandwiches and ice cream. For groceries, locals head to Schnucks in Weldon Spring. Defiance Ridge Vineyards offers hilltop views and locally made wines, and the area is dotted with other vineyards along Highway 94. Matson Hill State Park has 475 acres of forestland and 6 miles of trails, including gravity-flow paths for mountain biking. The park also houses the historic Hays Home, dating back to the 1830s. Despite residential growth, Defiance maintains its rural feel, providing a unique lifestyle within St. Charles County.

Learn more about living in Defiance

Frequently Asked Questions

What is the average home price in Defiance, MO?

Homes for sale in Defiance, MO have an average home price of $874,637.

How many homes have sold over the last 12 months in Defiance, MO?

44 homes have sold in Defiance, MO over the last 12 months.

What are the most popular zip codes in Defiance, MO?

The most popular zip codes in Defiance, MO include 63341, 63073, 63348, 63332 and 63069.

How much do you need to make to afford a house in Defiance?

The median home price in Defiance is $757,500. If you put a 20% down payment of $151,500 and had a 30-year fixed mortgage with an interest rate of 6.11%, your estimated principal and interest payment would be $3,680 a month plus property taxes, HOA fees, home insurance, PMI, and utilities. Using the 28% rule, you would need to make at least $158K a year to afford the median home price in Defiance. Learn how much home you can afford with our Home Affordability Calculator.

How are the schools in Defiance, MO?

Defiance, MO has highly rated public and private schools. Some of the best schools in Defiance based on Niche Grades are Francis Howell High School, Daniel Boone Elementary School and Francis Howell Middle School. Browse all the schools in Defiance, MO to learn more.

Home Trends in Defiance, MO

On average, homes in Defiance, MO sell after 75 days on the market compared to the national average of 55 days. The median sale price for homes in Defiance, MO over the last 12 months is $615,000, down 2% from the median home sale price over the previous 12 months.

Housing Trends

Median Sale Price

$615,000

Median Single Family Sale Price

$685,000

Average Price Per Sq Ft

$219

Number of Homes for Sale

Last 12 months Home Sales

Months of Supply

3.50

Median List Price

$757,500

Median Change From 1st List Price

Median Home Sale Price YoY Change

-2%

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Defiance Types of Homes for Sale

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More About Living in Defiance

Defiance Homes for Sale by Style

Defiance Ranch Style Homes for Sale

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