Defiance, MO Homes for Sale

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  /87

  $950,000

  • 4 Beds
  • 5 Baths
  • 4,298 Sq Ft

  4075 Highway D, Defiance, MO 63341

  Luxury country living meets everyday convenience on this exceptional 10 unrestricted acre estate! Perfectly situated just minutes from Highway 40/61, Highway N, Winghaven shopping, New Melle, Augusta, and Defiance, you’ll enjoy the peace and privacy of country living while remaining close to award-winning wineries, restaurants, shopping, and an easy commute.Beautifully updated and

  

  Samantha Richardson

  Main St. Real Estate

  4075 Highway D, Defiance, MO 63341
• Explore Defiance

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  /43

  $899,999

  $50K PRICE DROP

  • 4 Beds
  • 4.5 Baths
  • 4,579 Sq Ft

  50 Sunfish Dr, Defiance, MO 63341

  Experience the best of Callaway Valley living—where privacy, luxury, and lifestyle align.Situated on a stunning 6-acre estate with coveted lake rights, this exceptional property offers a rare blend of space, serenity, and high-end living.The heart of the home is a chef’s dream kitchen, beautifully updated in 2022 with a 48” Wolf gas range with pot filler, Sub-Zero refrigerator, expansive

  

  Amanda Alejandro

  Realty Shop

  50 Sunfish Dr, Defiance, MO 63341
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  /99

  $1,690,000

  $100K PRICE DROP

  • 4 Beds
  • 3.5 Baths
  • 5,609 Sq Ft

  4325 Hueffmeier Rd, Defiance, MO 63341

  Welcome home to this beautifully appointed brick ranch that truly has it all—inside and out. Situated on approximately 10+/- acres, this property offers the perfect blend of privacy, space, and resort-style living. Step into your own private backyard retreat featuring a stunning in-ground saltwater pool (9.5 ft deep), complete with heating and cooling for extended seasonal enjoyment. The

  Scott Dyer MO Realty

  4325 Hueffmeier Rd, Defiance, MO 63341
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  /16

  $840,000

  • Land
  • 20 Acres
  • $42,000 per Acre

  20 + - Ac Highway D, Defiance, MO 63341

  Stunning 20 Acre Rural Retreat Endless Possibilities Await! Discover the beauty and serenity of this 20-acre gem in the heart of nature! Nestled in the highly sought-after Francis Howell School District, this picturesque property offers rolling hills, open fields, and scattered wooded areas, creating the perfect blend of open space and privacy. A scenic creek meanders through the landscape,

  Eric Merchant Trophy Properties and Auction

  20 + - Ac Highway D, Defiance, MO 63341
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  /3

  $199,900

  $100K PRICE DROP

  • Land
  • 3.45 Acres
  • $57,942 per Acre

  0 Defiance Rd Unit 22755774, Defiance, MO 63341

  This expansive 3.45-acre lot is ideally situated in the heart of downtown Defiance, offering a rare combination of space and convenience. The property features a charming, rustic red barn that adds a touch of character and potential for various uses, from storage to creative projects. The ample size of the lot provides plenty of room for development, gardening, or outdoor activities. With its

  MO Realty MO Realty

  0 Defiance Rd Unit 22755774, Defiance, MO 63341
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  /23

  $2,911,000

  • Land
  • 82 Acres
  • $35,500 per Acre

  82 + - Ac Highway D, Defiance, MO 63341

  Stunning 82+/- Acre Rural Retreat Endless Possibilities Await! Discover the beauty and serenity of this gem in the heart of nature! Nestled in the highly sought-after Francis Howell School District, this picturesque property offers rolling hills, open fields, and scattered wooded areas, creating the perfect blend of open space and privacy. A scenic creek meanders through the landscape, adding to

  Eric Merchant Trophy Properties and Auction

  82 + - Ac Highway D, Defiance, MO 63341
• 

  /2

  $305,000

  • Land
  • 5.03 Acres
  • $60,636 per Acre

  3077 S Missouri 94, Defiance, MO 63341

  Rare opportunity to own 5.03 acres overlooking the Missouri River Valley just outside the heart of Defiance. Enjoy sweeping sunrise views, a private setting, and plenty of usable yard space for a custom home, outdoor living, gardens, or additional structures. A private lane provides direct access to Hwy 94 while maintaining a peaceful setting. The existing clearing offers an excellent homesite

  Meyer Auctions Meyer & Company Real Estate and Auctions

  3077 S Missouri 94, Defiance, MO 63341
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  /4

  $334,200

  Under Contract

  • Land
  • 5.57 Acres
  • $60,000 per Acre

  28 Meditation Way, Defiance, MO 63341

  Nestled in the heart of St. Charles County in Defiance and near New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 lots already sold in the first

  Toni Dillon Trophy Properties & Auction

  28 Meditation Way, Defiance, MO 63341
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  /2

  $425,000

  • Land
  • 8.5 Acres
  • $50,000 per Acre

  0 Defiance Rd Unit MIS26025560, Defiance, MO 63341

  8.5+/- Fabulous acres that offer a combination of open land, level to rolling hills, wooded land & access to a shared pond. Rare opportunity to own this beautiful, very scenic acreage. The perfect place for an equestrian homestead, a country estate, contemporary farmhouse or your DREAM development. This acreage offers seclusion, country style living, with an abundant wildlife habitat for the avid

  Catherine Shaw-Connely Tom Shaw, REALTORS

  0 Defiance Rd Unit MIS26025560, Defiance, MO 63341
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  /6

  $1

  • 3 Beds
  • 4 Baths
  • 2,090 Sq Ft

  1 Country Life, Defiance, MO 63341

  Improvements include a 2090 sq. ft. ranch home built in 1980. The home features 3 bedrooms, 2 full baths & 2 half baths, custom kitchen/breakfast room w/updated stainless steel appliances & granite marble top center island & counter tops, great room w/woodburning stone fireplace, wood floors, formal dining room, formal entry, main floor laundry, huge master bedroom w/large master bath w/tub &

  Dusty Thornhill Thornhill Real Estate & Auction Co

  1 Country Life, Defiance, MO 63341
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  /4

  $587,000

  • Land
  • 5.87 Acres
  • $100,000 per Acre

  4 Cooper's Ct, Defiance, MO 63341

  Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

  Toni Dillon Trophy Properties & Auction

  4 Cooper's Ct, Defiance, MO 63341
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  /4

  $318,600

  Under Contract

  • Land
  • 5.31 Acres
  • $60,000 per Acre

  36 Meditation Way, Defiance, MO 63341

  Nestled in the heart of St. Charles County in Defiance and near New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 lots already sold in the first

  Toni Dillon Trophy Properties & Auction

  36 Meditation Way, Defiance, MO 63341
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  /52

  $625,000

  Open Sun 1PM - 3PM

  • 4 Beds
  • 2.5 Baths
  • 2,096 Sq Ft

  44 Wilderness Ln, Defiance, MO 63341

  Tucked away at the end of a cul-de-sac and lined by trees on a gorgeous 3 acre lot this lovely, private hideaway is calling you home to a welcoming 2 story gem, Woodworking Shop or She shed, Barn and pasture. Enter to ceramic tile entry, coat closet and powder room. Grand staircase in entry with wood rails and wrought iron balusters. Large L shaped great room with solid oak floors and wood stove.

  Mike Simms Worth Clark Realty

  44 Wilderness Ln, Defiance, MO 63341
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  /4

  $279,900

  • Land
  • 5 Acres
  • $55,980 per Acre

  5011 Lily Ridge, Defiance, MO 63341

  Sunset Estates in St. Charles County MO. Four Luxurious home sites, on 5 acre lots. Located in the heart of Defiance and wine country. Bring your own builder/plans and build your dream home on one of these premium secluded, all wooded lots. Homesites are located on a private street with cul-de-sac. Homeowners will enjoy the peace and quiet, along with privacy. County water and high-speed

  Bill McNair II First American Real Estate Co.

  5011 Lily Ridge, Defiance, MO 63341
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  /2

  $449,900

  $35K PRICE DROP

  • Land
  • 9.05 Acres
  • $49,713 per Acre

  2461 Highway F, Defiance, MO 63341

  This mostly level 9.05 Acres of land includes a well with a solar-powered pump and five frost-free spigots on the southeast side—perfect for gardens, orchards, or hobby farming. A gravel driveway has already been added along the south side for convenient access. Only a small portion of the front is in the 100-year floodplain, while the majority of the property sits outside of it, giving you

  Catherine Shaw-Connely Tom Shaw, REALTORS

  2461 Highway F, Defiance, MO 63341
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  /56

  $850,000

  Pending

  • 5 Beds
  • 5 Baths
  • 4,749 Sq Ft

  769 Old Colony Rd, Defiance, MO 63341

  Experience refined country living in the heart of Missouri wine country at this stunning custom-built brick atrium ranch in Defiance. Nestled on approximately 5 picturesque acres, this exceptional estate offers nearly 5,000 square feet of beautifully finished living space designed for both luxury and comfort. Step inside and be captivated by the dramatic atrium wall of windows that floods the

  Lori Dillick Coldwell Banker Realty - Gundaker

  769 Old Colony Rd, Defiance, MO 63341
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  /4

  $151,000

  • Land
  • 5.03 Acres
  • $30,020 per Acre

  180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341

  Awesome lot available in a rural subdivision

  Dan Lauderdale Lauderdale Realty

  180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341
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  /79

  $1,400,000

  Pending

  • 5 Beds
  • 7 Baths
  • 6,521 Sq Ft

  220 Northlind Dr, Defiance, MO 63341

  Stunning brick and stone ranch-style home sitting on 3 private acres surrounded by mature trees and scenic views! This custom-built home boasts 5 bedrooms, 4 full bathrooms, 3 half bathrooms, and over 6,500 square feet of living space including the finished walkout lower level. The property also features an attached 3 car garage and a detached 52 x 40 foot detached garage with a bonus room. The

  Mark Gellman EXP Realty, LLC

  220 Northlind Dr, Defiance, MO 63341
• 

  

  /73

  $489,000

  Pending

  • 3 Beds
  • 2 Baths
  • 2,156 Sq Ft

  7 Wilderness Ln, Defiance, MO 63341

  Hard to Find Log Cabin on 3 very usable Acres in the Heart of Defiance! Get ready to unleash your inner explorer at 7 Wilderness Lane. Built in 1978, this charming single-family lob cabin-type home is more than just a residence—it’s your gateway to adventure and peaceful country living. Inside, you’ll find three cozy bedrooms and two full bathrooms, thoughtfully designed for everyday comfort and

  Sandi Alexander RE/MAX EDGE

  7 Wilderness Ln, Defiance, MO 63341
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  /9

  $151,000

  • Land
  • 5.05 Acres
  • $29,901 per Acre

  130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341

  Great Building Lot. Schedule an appointment and view this property today.

  Dan Lauderdale Lauderdale Realty

  130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341
• 

  

  /4

  $350,000

  • Land
  • 5 Acres
  • $70,000 per Acre

  517 Callaway Estates Dr, Defiance, MO 63341

  Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

  Stephen Kaiser Trophy Properties & Auction

  517 Callaway Estates Dr, Defiance, MO 63341
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  /2

  $152,000

  • Land
  • 5.06 Acres
  • $30,040 per Acre

  120 Steeple Point Dr Lot #13 Dr, Defiance, MO 63341

  Another Great Lot in the Steeple Point Subdivision. Schedule your appointment to view today.

  Dan Lauderdale Lauderdale Realty

  120 Steeple Point Dr Lot #13 Dr, Defiance, MO 63341
• 

  

  /4

  $350,000

  Under Contract

  • Land
  • 5 Acres
  • $70,000 per Acre

  513 Callaway Estates Dr, Defiance, MO 63341

  Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 already sold in the first 18

  Toni Dillon Trophy Properties & Auction

  513 Callaway Estates Dr, Defiance, MO 63341
• 

  

  /44

  $1,430,000

  $69K PRICE DROP Pending

  • 4 Beds
  • 3.5 Baths
  • 4,461 Sq Ft

  115 Markham Trail Ln, Defiance, MO 63341

  Looking for the perfect multi-generational home or private in-law suite with its own entrance? This custom-built Lombardo Ranch on 5.44 acres checks every box. Thoughtfully designed with high-end upgrades throughout, this home blends style, comfort, and function in every detail.On the main level, you’ll find a chef’s kitchen featuring white custom cabinetry, quartz countertops, a striking

  Madison Lantz Berkshire Hathaway HomeServices Select Properties

  115 Markham Trail Ln, Defiance, MO 63341
• 

  

  /4

  $350,000

  Under Contract

  • Land
  • 5 Acres
  • $70,000 per Acre

  503 Callaway Estates Dr, Defiance, MO 63341

  Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 already sold in the first 18

  Toni Dillon Trophy Properties & Auction

  503 Callaway Estates Dr, Defiance, MO 63341
• 

  /2

  $238,900

  • Land
  • 8.89 Acres
  • $26,873 per Acre

  110 Steeple Point Dr Lot # 14 Dr, Defiance, MO 63341

  WOW, nearly 9 acres for under $250,000. Schedule an appointment and view this lot today.

  Dan Lauderdale Lauderdale Realty

  110 Steeple Point Dr Lot # 14 Dr, Defiance, MO 63341
• 

  

  /25

  $305,000

  $20K PRICE DROP

  • Land
  • 5.03 Acres
  • $60,636 per Acre

  3077 Highway 94 S, Defiance, MO 63341

  Rare opportunity to own 5.03 acres overlooking the Missouri River Valley just outside the heart of Defiance. Enjoy sweeping sunrise views, a private setting, and plenty of usable yard space for a custom home, outdoor living, gardens, or additional structures. A private lane provides direct access to Hwy 94 while maintaining a peaceful setting. The existing clearing offers an excellent homesite

  Sherry Ruyle Meyer & Company Real Estate

  3077 Highway 94 S, Defiance, MO 63341
• 

  

  /18

  $650,000

  • 3 Beds
  • 2 Baths
  • 2,013 Sq Ft

  215 Rugged Acres Ln, Defiance, MO 63341

  Custom built, beautifully crafted home with over 2,000 sq feet of living space with luxury finishes. Located on 5 unrestricted acres, mostly wooded, outside New Melle in the heart of wine country. Private and peacefully located with access to major roads, living in country with easy access to all modern conveniences. Stepping Inside you are greeted with soaring 10' ceilings, open floor plan from

  Dolly Sjoholm Call Dolly, LLC

  215 Rugged Acres Ln, Defiance, MO 63341
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  /5

  $279,900

  • Land
  • 5 Acres
  • $55,980 per Acre

  5001 Lily Ridge Ct, Defiance, MO 63341

  Four Luxurious home sites, on 5 acre lots. Sunset Estates in St. Charles County MO. Located in the heart of Defiance and wine country. Bring your own builder/plans and build your dream home on one of these premium secluded, all wooded lots. Homesites are located on a private street with cul-de-sac. Homeowners will enjoy the peace and quiet, along with privacy. County water and high-speed

  Bill McNair II First American Real Estate Co.

  5001 Lily Ridge Ct, Defiance, MO 63341
• 

  

  /37

  $535,000

  $14K PRICE DROP

  • 3 Beds
  • 2 Baths
  • 1,600 Sq Ft

  3877 Highway D, Defiance, MO 63341

  Spacious ranch on 6 gorgeous acres conveniently located just minutes from wineries, schools, shopping and highways! This charming 3 bedroom, 2 bath home comes complete with main floor laundry, full, unfinished basement, and a primary bedroom with walk-in closet and ensuite bath. Besides the 2-car attached garage, there is a 28’x60’ insulated metal outbuilding with concrete floor, electric and 220

  Sherry Raleigh-Adams Wolfe Realty

  3877 Highway D, Defiance, MO 63341
• 

  

  /58

  $749,900

  $45K PRICE DROP

  • 4 Beds
  • 3.5 Baths
  • 4,564 Sq Ft

  2 Woodridge Dr, Defiance, MO 63341

  This handsome and spacious 4 bedroom 4 bath ranch home is beautifully situated on a 3 acre lot surrounded by mature trees creating a private, peaceful oasis for relaxing and entertaining. The recently refinished wide-plank hardwood floors are simply outstanding. A large living/family room with fireplace leads to an outdoor brick terrace overlooking the salt water pool with waterfall. The custom

  John Zarky Janet McAfee Inc.

  2 Woodridge Dr, Defiance, MO 63341
• 

  

  /4

  $154,000

  • Land
  • 5.13 Acres
  • $30,019 per Acre

  150 Steeple Point Dr Lot #10 Dr, Defiance, MO 63341

  Gorgeous Lot in Steeple Point. Great views and quite living.

  Dan Lauderdale Lauderdale Realty

  150 Steeple Point Dr Lot #10 Dr, Defiance, MO 63341
• 

  

  /10

  $499,900

  Under Contract

  • 3 Beds
  • 2.5 Baths
  • 1,978 Sq Ft

  2540 S Highway 94, Defiance, MO 63341

  Country living on 5.21+/- level STUNNING acres in unincorporated Defiance! A tree lined driveway leads to a CHARMING, RANCH home with 3 bedrooms, 2.5 baths & 1,978+/- SqFt of living space that offers an AWESOME, 30’ x 24’, 2-car, detached garage & shed. Partially covered front porch greets you as you step inside the entry foyer. Step down, living room boasts a floor-to-ceiling brick wood burning

  Catherine Shaw-Connely Tom Shaw, REALTORS

  2540 S Highway 94, Defiance, MO 63341
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  /78

  $620,000

  • 4 Beds
  • 3.5 Baths
  • 3,057 Sq Ft

  8 Whippoorwill Ct, Defiance, MO 63341

  Escape to your own private retreat with this stunning log home nestled on 3 picturesque acres, where peaceful country living meets modern comfort. Surrounded by mature trees and breathtaking natural beauty, you'll enjoy the serenity of nature while remaining just 15 minutes from Highway 40, offering the perfect balance of privacy and convenience. Enjoy the view from either the fully covered front

  Jennifer Bommarito Fox & Riley Real Estate

  8 Whippoorwill Ct, Defiance, MO 63341
• 

  

  /4

  $350,000

  • Land
  • 5 Acres
  • $70,000 per Acre

  12 Still Waters Ct, Defiance, MO 63341

  Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

  Toni Dillon Trophy Properties & Auction

  12 Still Waters Ct, Defiance, MO 63341
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  /67

  $2,750,000

  $25K PRICE DROP

  • 3 Beds
  • 4.5 Baths
  • 4,037 Sq Ft

  353 Callaway Ridge Dr, Defiance, MO 63341

  Experience the ultimate in privacy and natural beauty with this stunning custom waterfront property nestled on 37+ mostly wooded acres fronting the serene waters of Callaway Valley Lake. Crafted with exceptional attention to detail, this one-of-a-kind property showcases rich woodwork and impeccable craftsmanship throughout. Highlighted by a grand wood-paneled ceiling with softly arched beams, and

  Kelly Beanblossom-Schlake Blondin Group, Inc

  353 Callaway Ridge Dr, Defiance, MO 63341
• 

  

  /43

  $679,900

  $20K PRICE DROP

  • 3 Beds
  • 2.5 Baths
  • 1,944 Sq Ft

  1451 Highway F, Defiance, MO 63341

  Rarely does an opportunity like this come available in Defiance! Located in the beautiful Femme Osage valley, nestled on 9+ picturesque acres, this 3 bed, 2.5 home offers the perfect blend of privacy, space, and comfort. The setting is rural but convenient to highway 64/40, Chesterfield, Wentzville, and Francis Howell schools. Step inside to find hardwood floors throughout the main level, leading

  Matthew Lauman Magnolia Real Estate

  1451 Highway F, Defiance, MO 63341
• 

  

  /4

  $350,000

  • Land
  • 5 Acres
  • $70,000 per Acre

  510 Callaway Estates Dr, Defiance, MO 63341

  Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

  Toni Dillon Trophy Properties & Auction

  510 Callaway Estates Dr, Defiance, MO 63341
• 

  

  /40

  $625,000

  $25K PRICE DROP

  • 5 Beds
  • 3 Baths
  • 3,391 Sq Ft

  1510 Highway Dd, Defiance, MO 63341

  Welcome to 1510 Highway DD in unincorporated St. Charles County and in the Francis Howell School District. Nestled on 3 beautiful acres in St. Charles County, this rare 5 bedroom ranch offers the perfect blend of peaceful living while keeping you just minutes from shopping, restaurants, and major highways. Step inside to find an expansive open layout where the kitchen is a true centerpiece,

  Timothy Koppel Berkshire Hathaway HomeServices Select Properties

  1510 Highway Dd, Defiance, MO 63341
• 

  

  /69

  $2,375,000

  • 3 Beds
  • 4.5 Baths
  • 4,037 Sq Ft

  353 Callaway Ridge (25 5) Dr, Defiance, MO 63341

  Experience the ultimate in privacy and natural beauty with this stunning custom waterfront property nestled on 25.5+/- mostly wooded acres with frontage on the serene waters of Callaway Valley Lake. Crafted with exceptional attention to detail, this one-of-a-kind property showcases rich woodwork and impeccable craftsmanship throughout. Highlighted by a grand wood-paneled ceiling with softly

  Kelly Beanblossom-Schlake Blondin Group, Inc

  353 Callaway Ridge (25 5) Dr, Defiance, MO 63341

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