Defiance, MO Homes for Sale

Q: What are the most popular zip codes in Defiance, MO?

The most popular zip codes in Defiance, MO include 63341 , 63073 , 63332 , 63348 and 63005 .

/30
$639,900
- 4 Beds
- 3.5 Baths
- 2,982 Sq Ft
1329 Lakeway Dr, Defiance, MO 63341

Experience refined country living at its finest on this exceptional 3-acre, tree-lined estate. Perfectly positioned for privacy and tranquility, the home invites you to unwind on the expansive deck, where breathtaking views of nature and wildlife create a serene, resort-like backdrop. Step inside to discover a distinctive floor plan designed for both elegance and comfort. The upper level is

Amanda Alejandro

Realty Shop

(636) 837-0477

1329 Lakeway Dr, Defiance, MO 63341
Explore Defiance
/3
$199,900
- Land
- 3.45 Acres
- $57,942 per Acre
0 Defiance Rd Unit 22755774, Defiance, MO 63341

This expansive 3.45-acre lot is ideally situated in the heart of downtown Defiance, offering a rare combination of space and convenience. The property features a charming, rustic red barn that adds a touch of character and potential for various uses, from storage to creative projects. The ample size of the lot provides plenty of room for development, gardening, or outdoor activities. With its

MO Realty MO Realty Home & Land

0 Defiance Rd Unit 22755774, Defiance, MO 63341
/50
$1,550,000
- 3 Beds
- 4.5 Baths
- 4,037 Sq Ft
353 Callaway Ridge Dr, Defiance, MO 63341

Experience this stunning custom ranch home nestled on 5 park-like acres in the highly desirable Callaway Valley subdivision which includes lake rights to enjoy the 168 acre Community Lake! Crafted with exceptional attention to detail, this one-of-a-kind property showcases rich woodwork and impeccable craftsmanship throughout. Highlighted by a grand wood-paneled ceiling with softly arched beams,

Kelly Beanblossom-Schlake Blondin Group, Inc

353 Callaway Ridge Dr, Defiance, MO 63341
/71
$1,249,000
- 5 Beds
- 4 Baths
- 6,180 Sq Ft
707 Crown Pointe Farms, Defiance, MO 63341

Welcome to 707 Crown Pointe Farms, a premier estate in the heart of Defiance. Privately situated on a cul-de-sac within the Francis Howell School District, this custom-built ranch rests on 4.3 acres and offers nearly 6,200 square feet of finished living space. The main level showcases a soaring great room with vaulted ceilings, a floor-to-ceiling stone woodburning fireplace, built-in shelving,

Matthew Becker Magnolia Real Estate

707 Crown Pointe Farms, Defiance, MO 63341
/72
$1,199,000
- 4 Beds
- 5 Baths
- 2,436 Sq Ft
4075 Highway D, Defiance, MO 63341

This is a must see!!! This beautifully updated, well maintained home with 3 beds, (3) full (2) 1/2 baths is on 10 flat acres. Primary bedroom has a bay window, separate shower/jacuzzi tub. Family room has a wood burning fireplace. Relax 0on the covered porch that overlooks a water feature and the lake. Kitchen has granite countertops, propane cooktop, double ovens. double sink, microwave and

John Shaw Tom Shaw, REALTORS

4075 Highway D, Defiance, MO 63341
/49
$1,289,500
- 4 Beds
- 4.5 Baths
- 4,870 Sq Ft
14 Callaway Ridge Ct, Defiance, MO 63341

Looking for a home that you never need to vacation from.....then this is the one! This stunning custom ranch offers over 4,800 sqft of spacious finished living space with 10 foot ceilings on the main level and 9 foot in the lower level. Natural light abounds throughout the main living area offering scenic views, wood burning fireplace that flows into the chef's gourmet kitchen complete with range

Jason Jacobs Legacy Realty Group

14 Callaway Ridge Ct, Defiance, MO 63341
/98
$1,389,000 New Construction
- 5 Beds
- 5.5 Baths
- 5,504 Sq Ft
170 Blue Sky, Defiance, MO 63341

Brand new custom-built home on 3+ wooded acres in Kohler Estates subdivision. Features 4 bedrooms and 5 1/2 baths, a oversized 4 car garage with stair access to basement, a Great Room with a stone gas fireplace, with custom bookshelves, Gourmet kitchen offers custom cabinetry with quartz countertops, tile backsplash, and a complete appliance package, and walk-in pantry with custom shelving.

Chris Dawson Orenda Real Estate Services

170 Blue Sky, Defiance, MO 63341
/47
$699,900
- 4 Beds
- 2.5 Baths
- 2,556 Sq Ft
1330 Lake Hollow Dr, Defiance, MO 63341

Enjoy the serenity of your own private retreat, surrounded by trees and nature while still being just minutes from shopping, dining, and entertainment. Inside, the stunning kitchen is a true showpiece—featuring quartz countertops, cherry cabinetry, stainless steel appliances, a massive island, and a spacious walk-in pantry. The main level shines with new 5” wide wood-plank luxury vinyl flooring,

Suzanne Matyiko ReeceNichols Real Estate

1330 Lake Hollow Dr, Defiance, MO 63341
/5
$325,000
- Land
- 5 Acres
- $65,000 per Acre
22 Sunset Ct, Defiance, MO 63341

Welcome to Callaway Lake Estates...Lot #99, an exclusive luxury subdivision nestled in the serene countryside of unincorporated Saint Charles County, Missouri. This prestigious community offers 108 breathtaking lots, ranging from 5 to 15 acres, providing the perfect canvas for your custom dream home. With a minimum build requirement of 2,400 sq. ft. and architectural approval, each estate

Toni Dillon Trophy Properties & Auction

22 Sunset Ct, Defiance, MO 63341
/51
$385,000
- 3 Beds
- 2 Baths
- 1,225 Sq Ft
2934 S Highway 94, Defiance, MO 63341

Professionally Restored Historic Gem in the Heart of Wine Country Step into Defiance history—with a modern-day glow-up. Built in 1915 and now completely reimagined by a local homebuilder and professional interior designer, this 110-year-old farmhouse has been given new life with a full restoration that blends old-world charm and today’s luxuries. This is no ordinary flip—this is craftsmanship

Chris Neskar Compass Realty Group

2934 S Highway 94, Defiance, MO 63341
/52
$729,000
- 5 Beds
- 3.5 Baths
- 3,846 Sq Ft
3940 Indian Ridge Ln, Defiance, MO 63341

CUSTOM-BUILT ATRIUM RANCH home on 3+/- fabulous level/sloping acres in Defiance in the quite/desirable subdivision of Indian Ridge Farms! This 5 bedroom, 3.5 bath home with 3,846+/- sq ft of living space offers a 9’+/- ceilings through-out & 2-car oversized attached garage. Covered front porch greets you as you step inside the entry foyer. Dining room, accented with job-finished wood flooring,

Catherine Shaw-Connely Tom Shaw, REALTORS

3940 Indian Ridge Ln, Defiance, MO 63341
/95
$875,000
- 5 Beds
- 3.5 Baths
- 4,814 Sq Ft
3780 Forest Meadow Dr, Defiance, MO 63341

Experience refined country living in this stunning 1.5-story estate nestled on a peaceful 3.43-acre lot. This 5-bedroom, 3.5-bath home combines timeless design, modern updates, and luxurious comfort throughout. The gourmet kitchen impresses with white cabinetry, gleaming quartz countertops, a large center island, and an inviting eat-in peninsula. A spacious walk-in pantry and a convenient wet bar

Emily Brophy MO Realty

3780 Forest Meadow Dr, Defiance, MO 63341
/70
$2,775,000
- 3 Beds
- 4.5 Baths
- 4,037 Sq Ft
353 Callaway Ridge Dr, Defiance, MO 63341

Experience the ultimate in privacy and natural beauty with this stunning custom waterfront property nestled on 37+ mostly wooded acres fronting the serene waters of Callaway Valley Lake. Crafted with exceptional attention to detail, this one-of-a-kind property showcases rich woodwork and impeccable craftsmanship throughout. Highlighted by a grand wood-paneled ceiling with softly arched beams, and

Maureen Blondin Blondin Group, Inc

353 Callaway Ridge Dr, Defiance, MO 63341
/3
$338,650
- Land
- 5.21 Acres
- $65,000 per Acre
440 Stones Throw Ct, Defiance, MO 63341

Welcome to Callaway Lake Estates, an exclusive luxury subdivision nestled in the serene countryside of unincorporated Saint Charles County, Missouri. This prestigious community offers 108 breathtaking lots, ranging from 5 to 15 acres, providing the perfect canvas for your custom dream home. With a minimum build requirement of 2,400 sq. ft. and architectural approval, each estate combines elegance

Stephen Kaiser Trophy Properties & Auction

440 Stones Throw Ct, Defiance, MO 63341
/3
$412,800
- Land
- 6.88 Acres
- $60,000 per Acre
48 Watershed Ct, Defiance, MO 63341

Welcome to Callaway Lake Estates, an exclusive luxury subdivision nestled in the serene countryside of unincorporated Saint Charles County, Missouri. This prestigious community offers 108 breathtaking lots, ranging from 5 to 15 acres, providing the perfect canvas for your custom dream home. With a minimum build requirement of 2,400 sq. ft. and architectural approval, each estate combines elegance

Stephen Kaiser Trophy Properties & Auction

48 Watershed Ct, Defiance, MO 63341
/3
$325,000
- Land
- 5 Acres
- $65,000 per Acre
521 Callaway Estates Dr, Defiance, MO 63341

Welcome to Callaway Lake Estates, an exclusive luxury subdivision nestled in the serene countryside of unincorporated Saint Charles County, Missouri. This prestigious community offers 108 breathtaking lots, ranging from 5 to 15 acres, providing the perfect canvas for your custom dream home. With a minimum build requirement of 2,400 sq. ft. and architectural approval, each estate combines elegance

Stephen Kaiser Trophy Properties & Auction

521 Callaway Estates Dr, Defiance, MO 63341
/23
$300,000
- Land
- 5.01 Acres
- $59,907 per Acre
404 Stones Throw Ct, Defiance, MO 63341

Beautiful 5-acre building lot located in the highly sought-after gated community of Callaway Lake Estates! Bring your builder and design the home of your dreams while adhering to community building restrictions that help preserve the neighborhood’s character and value. Enjoy access to the 168-acre Callaway Lake, perfect for fishing, boating, and relaxing by the water. This prime lot is within the

Tim Phillips MO Realty

404 Stones Throw Ct, Defiance, MO 63341
/7
$310,000
- Land
- 6.08 Acres
- $50,987 per Acre
LOT - 3 98 Neal Ln, Defiance, MO 63341

Welcome to the beautiful River Bluff View Estates. This is your opportunity to own Lot 3—one of only three exclusive homesites in this brand-new luxury community. Perched on a scenic bluff with sweeping Missouri River views, Lot 3 offers the perfect canvas for your custom dream home. Just minutes from the heart of Defiance, you’ll enjoy easy access to award-winning wineries, craft breweries,

Chris Neskar Compass Realty Group

LOT - 3 98 Neal Ln, Defiance, MO 63341
/44
$775,000
- 4 Beds
- 3.5 Baths
- 3,341 Sq Ft
19 Jacks Cabin Dr, Defiance, MO 63341

Meticulously maintained 2-story traditional home with over 3,300 sf of finished living space and impressive landscape. Boasting 4 beds, 3.5 baths plus an office or nursery, sunroom and breakfast room. Entertain in style with a formal dining room. The chef's kitchen is a standout: plantation shutters, custom hickory cabinets, granite counters, center island, planning desk, and a double oven

Julie Burt Blondin Group, Inc

19 Jacks Cabin Dr, Defiance, MO 63341
/4
$502,000
- Land
- 5.02 Acres
- $100,000 per Acre
60 Lakefront Ct, Defiance, MO 63341

Welcome to Lot #60 in Callaway Lake Estates, an exclusive luxury subdivision nestled in the serene countryside of unincorporated Saint Charles County, Missouri. This prestigious community offers 108 breathtaking lots, ranging from 5 to 15 acres, providing the perfect canvas for your custom dream home. With a minimum build requirement of 2,400 sq. ft. and architectural approval, each estate

Toni Dillon Trophy Properties & Auction

60 Lakefront Ct, Defiance, MO 63341
/4
$325,000
- Land
- 5 Acres
- $65,000 per Acre
525 Callaway Estates Dr, Defiance, MO 63341

Welcome to Callaway Lake Estates...Lot #5, an exclusive luxury subdivision nestled in the serene countryside of unincorporated Saint Charles County, Missouri. This prestigious community offers 108 breathtaking lots, ranging from 5 to 15 acres, providing the perfect canvas for your custom dream home. With a minimum build requirement of 2,400 sq. ft. and architectural approval, each estate combines

Toni Dillon Trophy Properties & Auction

525 Callaway Estates Dr, Defiance, MO 63341
/4
$279,900
- Land
- 5 Acres
- $55,980 per Acre
5011 Lily Ridge, Defiance, MO 63341

Sunset Estates in St. Charles County MO. Four Luxurious home sites, on 5 acre lots. Located in the heart of Defiance and wine country. Bring your own builder/plans and build your dream home on one of these premium secluded, all wooded lots. Homesites are located on a private street with cul-de-sac. Homeowners will enjoy the peace and quiet, along with privacy. County water and high-speed

Bill McNair II First American Real Estate Co.

5011 Lily Ridge, Defiance, MO 63341
/4
$319,900
- Land
- 5 Acres
- $63,980 per Acre
5000 Lily Ridge, Defiance, MO 63341

Sunset Estates in St. Charles County MO. Four Luxurious home sites, on 5 acre lots. Located in the heart of Defiance and wine country. Bring your own builder/plans and build your dream home on one of these premium secluded, all wooded lots. Homesites are located on a private street with cul-de-sac. Homeowners will enjoy the peace and quiet, along with privacy. County water and high-speed

Bill McNair II First American Real Estate Co.

5000 Lily Ridge, Defiance, MO 63341
/5
$279,900
- Land
- 5 Acres
- $55,980 per Acre
5001 Lily Ridge Ct, Defiance, MO 63341

Four Luxurious home sites, on 5 acre lots. Sunset Estates in St. Charles County MO. Located in the heart of Defiance and wine country. Bring your own builder/plans and build your dream home on one of these premium secluded, all wooded lots. Homesites are located on a private street with cul-de-sac. Homeowners will enjoy the peace and quiet, along with privacy. County water and high-speed

Bill McNair II First American Real Estate Co.

5001 Lily Ridge Ct, Defiance, MO 63341
/4
$420,800
- Land
- 5.26 Acres
- $80,000 per Acre
449 Stones Throw Ct, Defiance, MO 63341

Welcome to Callaway Lake Estates, an exclusive luxury subdivision nestled in the serene countryside of unincorporated Saint Charles County, Missouri. This prestigious community offers 108 breathtaking lots, ranging from 5 to 15 acres, providing the perfect canvas for your custom dream home. With a minimum build requirement of 2,400 sq. ft. and architectural approval, each estate combines elegance

Toni Dillon Trophy Properties & Auction

449 Stones Throw Ct, Defiance, MO 63341
/4
$319,900
- Land
- 5 Acres
- $63,980 per Acre
5010 Lily Ridge, Defiance, MO 63341

Sunset Estates in St. Charles County MO. Four Luxurious home sites, on 5 acre lots. Located in the heart of Defiance and wine country. Bring your own builder/plans and build your dream home on one of these premium secluded, all wooded lots. Homesites are located on a private street with cul-de-sac. Homeowners will enjoy the peace and quiet, along with privacy. County water and high-speed

Bill McNair II First American Real Estate Co.

5010 Lily Ridge, Defiance, MO 63341
/6
$189,900
- Land
- 3.01 Acres
- $63,090 per Acre
121 Red Barn Ln, Defiance, MO 63341

Your plans, your builder. Level, open lot with woods along the back line. The last unbuilt lot remaining. One of only (9) lots in Femme Osage Valley subdivision. Public water. Blacktop Streets. 10 minutes from Hwy 40/61. Additional Rooms: In Platted Subdv.

John Shaw Tom Shaw, REALTORS

121 Red Barn Ln, Defiance, MO 63341

Missouri St. Charles County Defiance

Why Live in Defiance

Defiance, Missouri, is an unincorporated community in southwest St. Charles County, known for its expansive lots and rural charm. With a population of around 3,200, Defiance offers a blend of farms, vineyards and pastoral estates. Homes typically sit on lots of 5 acres or more, though 3-acre lots are also common. The Francis Howell School District serves the area, with students attending the highly rated Daniel Boone Elementary School, Francis Howell Middle School, and the newly relocated Francis Howell High School. Local attractions include the Defiance General Store on Highway 94, where residents can enjoy coffee, deli sandwiches and ice cream. For groceries, locals head to Schnucks in Weldon Spring. Defiance Ridge Vineyards offers hilltop views and locally made wines, and the area is dotted with other vineyards along Highway 94. Matson Hill State Park has 475 acres of forestland and 6 miles of trails, including gravity-flow paths for mountain biking. The park also houses the historic Hays Home, dating back to the 1830s. Despite residential growth, Defiance maintains its rural feel, providing a unique lifestyle within St. Charles County.

Learn more about living in Defiance

Frequently Asked Questions

What is the average home price in Defiance, MO?

Homes for sale in Defiance, MO have an average home price of $860,390.

Are home prices dropping in Defiance?

Yes, home prices in Defiance are down 16% in the last 12 months.

How many homes have sold over the last 12 months in Defiance, MO?

42 homes have sold in Defiance, MO over the last 12 months.

What are the most popular zip codes in Defiance, MO?

The most popular zip codes in Defiance, MO include 63341, 63073, 63332, 63348 and 63005.

How much do you need to make to afford a house in Defiance?

The median home price in Defiance is $700,000. If you put a 20% down payment of $140,000 and had a 30-year fixed mortgage with an interest rate of 6.19%, your estimated principal and interest payment would be $3,430 a month plus property taxes, HOA fees, home insurance, PMI, and utilities. Using the 28% rule, you would need to make at least $147K a year to afford the median home price in Defiance. Learn how much home you can afford with our Home Affordability Calculator.

How are the schools in Defiance, MO?

Defiance, MO has highly rated public and private schools. Some of the best schools in Defiance based on Niche Grades are Francis Howell High School, Daniel Boone Elementary School and Francis Howell Middle School. Browse all the schools in Defiance, MO to learn more.

Home Trends in Defiance, MO

On average, homes in Defiance, MO sell after 80 days on the market compared to the national average of 53 days. The median sale price for homes in Defiance, MO over the last 12 months is $585,000, down 8% from the median home sale price over the previous 12 months.

Housing Trends

Median Sale Price

$585,000

Median Single Family Sale Price

$639,900

Average Price Per Sq Ft

$231

Number of Homes for Sale

Last 12 months Home Sales

Months of Supply

3.10

Median List Price

$700,000

Median Change From 1st List Price

Median Home Sale Price YoY Change

-8%

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