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Defiance, MO Homes for Sale

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  • 50 Sunfish Dr, Defiance, MO 63341
    50 Sunfish Dr, Defiance, MO 63341
    50 Sunfish Dr, Defiance, MO 63341
    /43

    $899,999

    $50K PRICE DROP Under Contract
    • 4 Beds
    • 4.5 Baths
    • 4,579 Sq Ft

    50 Sunfish Dr, Defiance, MO 63341

    Experience the best of Callaway Valley living—where privacy, luxury, and lifestyle align.Situated on a stunning 6-acre estate with coveted lake rights, this exceptional property offers a rare blend of space, serenity, and high-end living.The heart of the home is a chef’s dream kitchen, beautifully updated in 2022 with a 48” Wolf gas range with pot filler, Sub-Zero refrigerator, expansive

    Agent Photo

    Amanda Alejandro

    Realty Shop

    50 Sunfish Dr, Defiance, MO 63341
  • 4325 Hueffmeier Rd, Defiance, MO 63341
    4325 Hueffmeier Rd, Defiance, MO 63341
    4325 Hueffmeier Rd, Defiance, MO 63341
    /99

    $1,595,000

    $195K PRICE DROP Pending
    • 4 Beds
    • 3.5 Baths
    • 5,609 Sq Ft

    4325 Hueffmeier Rd, Defiance, MO 63341

    Welcome home to this beautifully appointed 5,609 sq. ft. brick ranch situated on 9.87 surveyed acres, offering an exceptional combination of privacy, space, and resort-style living. Featuring 4 bedrooms and 3.5 baths, this impressive home provides generous living and entertaining spaces both inside and out. The backyard is your own private retreat, highlighted by a stunning in-ground saltwater

    Scott Dyer MO Realty

    4325 Hueffmeier Rd, Defiance, MO 63341
  • 0 Defiance Rd Unit 22755774, Defiance, MO 63341
    0 Defiance Rd Unit 22755774, Defiance, MO 63341
    0 Defiance Rd Unit 22755774, Defiance, MO 63341
    /3

    $199,900

    $100K PRICE DROP
    • Land
    • 3.45 Acres
    • $57,942 per Acre

    0 Defiance Rd Unit 22755774, Defiance, MO 63341

    This expansive 3.45-acre lot is ideally situated in the heart of downtown Defiance, offering a rare combination of space and convenience. The property features a charming, rustic red barn that adds a touch of character and potential for various uses, from storage to creative projects. The ample size of the lot provides plenty of room for development, gardening, or outdoor activities. With its

    MO Realty MO Realty

    0 Defiance Rd Unit 22755774, Defiance, MO 63341
  • 28 Meditation Way, Defiance, MO 63341
    28 Meditation Way, Defiance, MO 63341
    28 Meditation Way, Defiance, MO 63341
    /4

    $334,200

    Under Contract
    • Land
    • 5.57 Acres
    • $60,000 per Acre

    28 Meditation Way, Defiance, MO 63341

    Nestled in the heart of St. Charles County in Defiance and near New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 lots already sold in the first

    Toni Dillon Trophy Properties & Auction

    28 Meditation Way, Defiance, MO 63341
  • 0 Defiance Rd Unit MIS26025560, Defiance, MO 63341
    0 Defiance Rd Unit MIS26025560, Defiance, MO 63341
    /2

    $375,000

    $50K PRICE DROP
    • Land
    • 8.5 Acres
    • $44,118 per Acre

    0 Defiance Rd Unit MIS26025560, Defiance, MO 63341

    8.5+/- Fabulous acres that offer a combination of open land, level to rolling hills, wooded land & access to a shared pond. Rare opportunity to own this beautiful, very scenic acreage. The perfect place for an equestrian homestead, a country estate, contemporary farmhouse or your DREAM development. This acreage offers seclusion, country style living, with an abundant wildlife habitat for the avid

    Catherine Shaw-Connely Tom Shaw, REALTORS

    0 Defiance Rd Unit MIS26025560, Defiance, MO 63341
  • 1 Country Life, Defiance, MO 63341
    1 Country Life, Defiance, MO 63341
    1 Country Life, Defiance, MO 63341
    /6

    $1

    Pending
    • 3 Beds
    • 4 Baths
    • 2,090 Sq Ft

    1 Country Life, Defiance, MO 63341

    Improvements include a 2090 sq. ft. ranch home built in 1980. The home features 3 bedrooms, 2 full baths & 2 half baths, custom kitchen/breakfast room w/updated stainless steel appliances & granite marble top center island & counter tops, great room w/woodburning stone fireplace, wood floors, formal dining room, formal entry, main floor laundry, huge master bedroom w/large master bath w/tub &

    Dusty Thornhill Thornhill Real Estate & Auction Co

    1 Country Life, Defiance, MO 63341
  • 4 Cooper's Ct, Defiance, MO 63341
    4 Cooper's Ct, Defiance, MO 63341
    4 Cooper's Ct, Defiance, MO 63341
    /4

    $587,000

    • Land
    • 5.87 Acres
    • $100,000 per Acre

    4 Cooper's Ct, Defiance, MO 63341

    Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

    Toni Dillon Trophy Properties & Auction

    4 Cooper's Ct, Defiance, MO 63341
  • 36 Meditation Way, Defiance, MO 63341
    36 Meditation Way, Defiance, MO 63341
    36 Meditation Way, Defiance, MO 63341
    /4

    $318,600

    Under Contract
    • Land
    • 5.31 Acres
    • $60,000 per Acre

    36 Meditation Way, Defiance, MO 63341

    Nestled in the heart of St. Charles County in Defiance and near New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 lots already sold in the first

    Toni Dillon Trophy Properties & Auction

    36 Meditation Way, Defiance, MO 63341
  • 44 Wilderness Ln, Defiance, MO 63341
    44 Wilderness Ln, Defiance, MO 63341
    44 Wilderness Ln, Defiance, MO 63341
    /58

    $610,000

    Open Sun 1PM - 3PM $15K PRICE DROP
    • 4 Beds
    • 2.5 Baths
    • 3,000 Sq Ft

    44 Wilderness Ln, Defiance, MO 63341

    Embrace the serenity of this secluded 3-acre property at the end of a cul-de-sac, surrounded by trees and boasting not just one, but three separate buildings! The main 2-story home features Low Maintenance, Hail resistant Hardi Board Siding, offering possible lower insurance rates. Step inside to find a ceramic tile entry, coat closet, powder room, and a grand staircase with wood rails and

    Mike Simms Worth Clark Realty

    44 Wilderness Ln, Defiance, MO 63341
  • 5011 Lily Ridge, Defiance, MO 63341
    5011 Lily Ridge, Defiance, MO 63341
    5011 Lily Ridge, Defiance, MO 63341
    /4

    $279,900

    • Land
    • 5 Acres
    • $55,980 per Acre

    5011 Lily Ridge, Defiance, MO 63341

    Sunset Estates in St. Charles County MO. Four Luxurious home sites, on 5 acre lots. Located in the heart of Defiance and wine country. Bring your own builder/plans and build your dream home on one of these premium secluded, all wooded lots. Homesites are located on a private street with cul-de-sac. Homeowners will enjoy the peace and quiet, along with privacy. County water and high-speed

    Bill McNair II First American Real Estate Co.

    5011 Lily Ridge, Defiance, MO 63341
  • 2461 Highway F, Defiance, MO 63341
    2461 Highway F, Defiance, MO 63341
    /2

    $449,900

    $35K PRICE DROP
    • Land
    • 9.05 Acres
    • $49,713 per Acre

    2461 Highway F, Defiance, MO 63341

    This mostly level 9.05 Acres of land includes a well with a solar-powered pump and five frost-free spigots on the southeast side—perfect for gardens, orchards, or hobby farming. A gravel driveway has already been added along the south side for convenient access. Only a small portion of the front is in the 100-year floodplain, while the majority of the property sits outside of it, giving you

    Catherine Shaw-Connely Tom Shaw, REALTORS

    2461 Highway F, Defiance, MO 63341
  • 29 Greenview Dr, Defiance, MO 63341
    29 Greenview Dr, Defiance, MO 63341
    29 Greenview Dr, Defiance, MO 63341
    /70

    $665,999

    • 4 Beds
    • 4 Baths
    • 4,025 Sq Ft

    29 Greenview Dr, Defiance, MO 63341

    Set on 9.5 wooded acres, this meticulously maintained 4 bedroom, 4 bath ranch offers the kind of privacy and quiet that is getting harder to find. No traffic noise, no neighbors looking in, just mature timber, rolling terrain and fabulous views in every season. The property even has its own waterfall.Inside, the spacious great room features a vaulted ceiling, skylights and a wall of windows

    Michael Nettemeyer Nettwork Global

    29 Greenview Dr, Defiance, MO 63341
  • 180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341
    180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341
    180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341
    /4

    $151,000

    • Land
    • 5.03 Acres
    • $30,020 per Acre

    180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341

    Awesome lot available in a rural subdivision

    Dan Lauderdale Lauderdale Realty

    180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341
  • 205 Howell Rd, Defiance, MO 63341
    205 Howell Rd, Defiance, MO 63341
    205 Howell Rd, Defiance, MO 63341
    /86

    $1,375,000

    $300K PRICE DROP Pending
    • 5 Beds
    • 6 Baths
    • 5,564 Sq Ft

    205 Howell Rd, Defiance, MO 63341

    Welcome to this exceptional custom estate on 3 picturesque acres in Defiance, offering panoramic views with no HOA and no restrictions. Two miles from Chandler Hill and Sugar Creek Winery. Designed for luxury living and incredible functionality, this one-of-a-kind property features 5 bedrooms, 6 full bathrooms, 2 full kitchens, and countless high-end upgrades throughout. The stunning main kitchen

    Yuriy Feldman EXP Realty, LLC

    205 Howell Rd, Defiance, MO 63341
  • 220 Northlind Dr, Defiance, MO 63341
    220 Northlind Dr, Defiance, MO 63341
    220 Northlind Dr, Defiance, MO 63341
    /79

    $1,400,000

    • 5 Beds
    • 7 Baths
    • 6,521 Sq Ft

    220 Northlind Dr, Defiance, MO 63341

    Stunning brick and stone ranch-style home sitting on 3 private acres surrounded by mature trees and scenic views! This custom-built home boasts 5 bedrooms, 4 full bathrooms, 3 half bathrooms, and over 6,500 square feet of living space including the finished walkout lower level. The property also features an attached 3 car garage and a detached 52 x 40 foot detached garage with a bonus

    Mark Gellman EXP Realty, LLC

    220 Northlind Dr, Defiance, MO 63341
  • 130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341
    130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341
    130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341
    /9

    $151,000

    • Land
    • 5.05 Acres
    • $29,901 per Acre

    130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341

    Great Building Lot. Schedule an appointment and view this property today.

    Dan Lauderdale Lauderdale Realty

    130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341
  • 517 Callaway Estates Dr, Defiance, MO 63341
    517 Callaway Estates Dr, Defiance, MO 63341
    517 Callaway Estates Dr, Defiance, MO 63341
    /4

    $350,000

    • Land
    • 5 Acres
    • $70,000 per Acre

    517 Callaway Estates Dr, Defiance, MO 63341

    Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

    Stephen Kaiser Trophy Properties & Auction

    517 Callaway Estates Dr, Defiance, MO 63341
  • 120 Steeple Point Dr Lot #13 Dr, Defiance, MO 63341
    120 Steeple Point Dr Lot #13 Dr, Defiance, MO 63341
    /2

    $152,000

    • Land
    • 5.06 Acres
    • $30,040 per Acre

    120 Steeple Point Dr Lot #13 Dr, Defiance, MO 63341

    Another Great Lot in the Steeple Point Subdivision. Schedule your appointment to view today.

    Dan Lauderdale Lauderdale Realty

    120 Steeple Point Dr Lot #13 Dr, Defiance, MO 63341
  • 3840 Rooster Ridge Ln, Defiance, MO 63341
    3840 Rooster Ridge Ln, Defiance, MO 63341
    3840 Rooster Ridge Ln, Defiance, MO 63341
    /83

    $699,900

    $35K PRICE DROP
    • 3 Beds
    • 3.5 Baths
    • 5,601 Sq Ft

    3840 Rooster Ridge Ln, Defiance, MO 63341

    Welcome to your own private retreat! Nestled on 3 beautiful acres with peaceful wooded views, this stunning 3-bedroom, 3.5-bath home offers the perfect blend of space, comfort, and entertainment. Whether you’re hosting friends for the big game, enjoying a relaxing evening surrounded by nature, or simply looking for room to spread out, this home has it all! The partially finished basement is made

    Brandon McNamee Mac Realty Group

    3840 Rooster Ridge Ln, Defiance, MO 63341
  • 51 Nordic Ln, Defiance, MO 63341
    51 Nordic Ln, Defiance, MO 63341
    51 Nordic Ln, Defiance, MO 63341
    /97

    $695,000

    • 3 Beds
    • 2.5 Baths
    • 2,852 Sq Ft

    51 Nordic Ln, Defiance, MO 63341

    Welcome to your dream home - a stunning, cozy, country home nestled in the middle of the woods on 3 acres. The newest addition is the August, 2026 upgraded, county approved septic system. This home is an oasis located in St. Charles County wine country, minutes from some of St. Charles ’best hiking & biking trails! This outdoor play scape was designed with the outdoors lover in mind and has ample

    Mary Bay Coldwell Banker Realty - Gundaker

    51 Nordic Ln, Defiance, MO 63341
  • 19 Greenview Dr, Defiance, MO 63341
    19 Greenview Dr, Defiance, MO 63341
    19 Greenview Dr, Defiance, MO 63341
    /45

    $599,900

    Open Sun 1PM - 3PM $25K PRICE DROP
    • 3 Beds
    • 2.5 Baths
    • 1,935 Sq Ft

    19 Greenview Dr, Defiance, MO 63341

    NEW PRICE! Stunning, Incredible views! Welcome to 19 Greenview Drive and to the beautiful community of Callaway Farms! This open and inviting home is a rare find! The style is known as an executive style reverse ranch floor plan with two levels of living. This dynamic floor plan offers numerous options for retirees, families, and for those looking for privacy with extended family. Walk in on the

    Michelle Syberg Mid America Property Partners

    19 Greenview Dr, Defiance, MO 63341
  • 2275 Highway F Unit LOT 1, Defiance, MO 63341
    2275 Highway F Unit LOT 1, Defiance, MO 63341
    2275 Highway F Unit LOT 1, Defiance, MO 63341
    /55

    $3,450,000

    • 5 Beds
    • 4 Baths
    • 2,815 Sq Ft

    2275 Highway F Unit LOT 1, Defiance, MO 63341

    Imagine owning a timeless piece of Missouri history. More than 250 years ago, the Osage people traveled these valleys, and pioneers like Daniel Boone, his son Nathan and nephew/adopted son Jonathan Bryan helped shape this remarkable landscape. A captivating driveway leads around to a ONE-OF-A-KIND property built in the 1840’s for Jonathan Bryan. “Bryan Mill” rests gracefully on 22+/- acres

    Catherine Shaw-Connely Tom Shaw, REALTORS

    2275 Highway F Unit LOT 1, Defiance, MO 63341
  • 513 Callaway Estates Dr, Defiance, MO 63341
    513 Callaway Estates Dr, Defiance, MO 63341
    513 Callaway Estates Dr, Defiance, MO 63341
    /4

    $350,000

    Under Contract
    • Land
    • 5 Acres
    • $70,000 per Acre

    513 Callaway Estates Dr, Defiance, MO 63341

    Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 already sold in the first 18

    Toni Dillon Trophy Properties & Auction

    513 Callaway Estates Dr, Defiance, MO 63341
  • 85 Mar Len Dr, Defiance, MO 63341
    85 Mar Len Dr, Defiance, MO 63341
    85 Mar Len Dr, Defiance, MO 63341
    /74

    $650,000

    • 3 Beds
    • 3 Baths
    • 3,730 Sq Ft

    85 Mar Len Dr, Defiance, MO 63341

    Tucked away on 4.75 beautiful acres surrounded by mature trees, this charming 3-bedroom, 3-bath home offers the perfect blend of privacy, space, and outdoor living. Step inside to a warm and inviting main level featuring vaulted ceilings, skylights, and natural wood accents throughout. The finished lower level provides plenty of additional living space, along with a separate finished room perfect

    Brittany Wasson Christal Property Group, LLC

    85 Mar Len Dr, Defiance, MO 63341
  • 503 Callaway Estates Dr, Defiance, MO 63341
    503 Callaway Estates Dr, Defiance, MO 63341
    503 Callaway Estates Dr, Defiance, MO 63341
    /4

    $350,000

    Under Contract
    • Land
    • 5 Acres
    • $70,000 per Acre

    503 Callaway Estates Dr, Defiance, MO 63341

    Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 already sold in the first 18

    Toni Dillon Trophy Properties & Auction

    503 Callaway Estates Dr, Defiance, MO 63341
  • 620 Forest Meadow Ct, Defiance, MO 63341
    620 Forest Meadow Ct, Defiance, MO 63341
    620 Forest Meadow Ct, Defiance, MO 63341
    /36

    $1,150,000

    Pending
    • 6 Beds
    • 5 Baths
    • 5,346 Sq Ft

    620 Forest Meadow Ct, Defiance, MO 63341

    Set on three private acres in Forest Lake Estates within the Francis Howell School District, this 5300+ square foot atrium ranch has been reimagined in its entirety. The kitchen, dining room, great room, bathrooms, flooring, lighting, and paint have all been renewed, allowing the home to feel newly built while retaining the scale and setting only a mature lot can offer. Inside, the great room

    Justin Michael

    620 Forest Meadow Ct, Defiance, MO 63341
  • 2323 Highway F Unit LOT 2, Defiance, MO 63341
    2323 Highway F Unit LOT 2, Defiance, MO 63341
    2323 Highway F Unit LOT 2, Defiance, MO 63341
    /10

    $699,900

    2323 Highway F Unit LOT 2, Defiance, MO 63341

    Imagine owning a piece of Missouri history. More than 250 years ago, the Osage people traveled these valleys, and pioneers like Daniel Boone, his son Nathan and adopted son Jonathan Bryan helped shape this remarkable landscape. Today, you have the rare opportunity to own approximately 12.5 acres of beautiful, untouched land just off Highway F, conveniently located near Augusta and Defiance, with

    Catherine Shaw-Connely Tom Shaw, REALTORS

    2323 Highway F Unit LOT 2, Defiance, MO 63341
  • 110 Steeple Point Dr Lot # 14 Dr, Defiance, MO 63341
    110 Steeple Point Dr Lot # 14 Dr, Defiance, MO 63341
    /2

    $238,900

    • Land
    • 8.89 Acres
    • $26,873 per Acre

    110 Steeple Point Dr Lot # 14 Dr, Defiance, MO 63341

    WOW, nearly 9 acres for under $250,000. Schedule an appointment and view this lot today.

    Dan Lauderdale Lauderdale Realty

    110 Steeple Point Dr Lot # 14 Dr, Defiance, MO 63341
  • 215 Rugged Acres Ln, Defiance, MO 63341
    215 Rugged Acres Ln, Defiance, MO 63341
    215 Rugged Acres Ln, Defiance, MO 63341
    /19

    $639,000

    Open Sun 12PM - 2PM $10K PRICE DROP
    • 3 Beds
    • 2 Baths
    • 2,013 Sq Ft

    215 Rugged Acres Ln, Defiance, MO 63341

    Experience peaceful country living in this stunning 2- year old ranch home nestled on 5 mostly wooded, unrestricted acres in the picturesque Femme Osage Valley. Ideally located just 3.5 miles from the charming town of New Melle, you'll enjoy the perfect balance of privacy and convenience, with nearby wineries, parks, and scenic countryside.This thoughtfully designed home offers 2,013 square

    Stacey Manner Call Dolly, LLC

    215 Rugged Acres Ln, Defiance, MO 63341
  • 5001 Lily Ridge Ct, Defiance, MO 63341
    5001 Lily Ridge Ct, Defiance, MO 63341
    5001 Lily Ridge Ct, Defiance, MO 63341
    /5

    $279,900

    • Land
    • 5 Acres
    • $55,980 per Acre

    5001 Lily Ridge Ct, Defiance, MO 63341

    Four Luxurious home sites, on 5 acre lots. Sunset Estates in St. Charles County MO. Located in the heart of Defiance and wine country. Bring your own builder/plans and build your dream home on one of these premium secluded, all wooded lots. Homesites are located on a private street with cul-de-sac. Homeowners will enjoy the peace and quiet, along with privacy. County water and high-speed

    Bill McNair II First American Real Estate Co.

    5001 Lily Ridge Ct, Defiance, MO 63341
  • 3877 Highway D, Defiance, MO 63341
    3877 Highway D, Defiance, MO 63341
    3877 Highway D, Defiance, MO 63341
    /37

    $505,900

    $43K PRICE DROP
    • 3 Beds
    • 2 Baths
    • 1,600 Sq Ft

    3877 Highway D, Defiance, MO 63341

    Spacious ranch on 6 gorgeous acres conveniently located just minutes from wineries, schools, shopping and highways! This charming 3 bedroom, 2 bath home comes complete with main floor laundry, full, unfinished basement, and a primary bedroom with walk-in closet and ensuite bath. Besides the 2-car attached garage, there is a 28’x60’ insulated metal outbuilding with concrete floor, electric and 220

    Sherry Raleigh-Adams Wolfe Realty

    3877 Highway D, Defiance, MO 63341
  • 150 Steeple Point Dr Lot #10 Dr, Defiance, MO 63341
    150 Steeple Point Dr Lot #10 Dr, Defiance, MO 63341
    150 Steeple Point Dr Lot #10 Dr, Defiance, MO 63341
    /4

    $154,000

    • Land
    • 5.13 Acres
    • $30,019 per Acre

    150 Steeple Point Dr Lot #10 Dr, Defiance, MO 63341

    Gorgeous Lot in Steeple Point. Great views and quite living.

    Dan Lauderdale Lauderdale Realty

    150 Steeple Point Dr Lot #10 Dr, Defiance, MO 63341
  • 50 Wilderness Ln, Defiance, MO 63341
    50 Wilderness Ln, Defiance, MO 63341
    50 Wilderness Ln, Defiance, MO 63341
    /57

    $650,000

    $25K PRICE DROP
    • 3 Beds
    • 2 Baths
    • 2,336 Sq Ft

    50 Wilderness Ln, Defiance, MO 63341

    Dont wait ! Homes like this don't come around often in sought after area of Defiance! Rare opportunity to have a beautiful like new ranch home on 3.05 wooded acres! paved roads plus concrete driveway and Just minutes to I-64 and Hwy 94 allowing easy commutes yet peaceful country living. 11 ft ceilings and all of the natural light that fills the entertaining area. The kitchen offers tons of white

    Lisa Coose-Burkemper Berkshire Hathaway HomeServices Select Properties

    50 Wilderness Ln, Defiance, MO 63341
  • 2323 Highway F Unit LOT 3, Defiance, MO 63341
    2323 Highway F Unit LOT 3, Defiance, MO 63341
    2323 Highway F Unit LOT 3, Defiance, MO 63341
    /4

    $1,899,900

    2323 Highway F Unit LOT 3, Defiance, MO 63341

    Imagine owning a piece of Missouri history. More than 250 years ago, the Osage people traveled these valleys, and pioneers like Daniel Boone, his son Nathan and adopted son Jonathan Bryan helped shape this remarkable landscape. Today, you have the rare opportunity to own approximately 38.5 acres of beautiful, untouched land just off Highway F, conveniently located near Augusta and Defiance, with

    Catherine Shaw-Connely Tom Shaw, REALTORS

    2323 Highway F Unit LOT 3, Defiance, MO 63341
  • 2323 Highway F Unit LOT 4, Defiance, MO 63341
    2323 Highway F Unit LOT 4, Defiance, MO 63341
    2323 Highway F Unit LOT 4, Defiance, MO 63341
    /4

    $1,699,000

    2323 Highway F Unit LOT 4, Defiance, MO 63341

    Imagine owning a piece of Missouri history. More than 250 years ago, the Osage people traveled these valleys, and pioneers like Daniel Boone, his son Nathan and adopted son Jonathan Bryan helped shape this remarkable landscape. Today, you have the rare opportunity to own approximately 32 acres of beautiful, untouched land just off Highway F, conveniently located near Augusta and Defiance, with

    Catherine Shaw-Connely Tom Shaw, REALTORS

    2323 Highway F Unit LOT 4, Defiance, MO 63341
  • 8 Whippoorwill Ct, Defiance, MO 63341
    8 Whippoorwill Ct, Defiance, MO 63341
    8 Whippoorwill Ct, Defiance, MO 63341
    /73

    $549,900

    $70K PRICE DROP
    • 4 Beds
    • 3.5 Baths
    • 3,057 Sq Ft

    8 Whippoorwill Ct, Defiance, MO 63341

    Escape to your own private retreat with this stunning log home nestled on 3 ACRES, where peaceful country living meets modern comfort. Surrounded by mature trees and breathtaking natural beauty, you'll enjoy the serenity of nature while remaining just 15 minutes from Highway 40 and Highway 70, offering the perfect balance of privacy and convenience. Enjoy the view from either the fully covered

    Jennifer Bommarito Fox & Riley Real Estate

    8 Whippoorwill Ct, Defiance, MO 63341
  • 510 Callaway Estates Dr, Defiance, MO 63341
    510 Callaway Estates Dr, Defiance, MO 63341
    510 Callaway Estates Dr, Defiance, MO 63341
    /4

    $350,000

    • Land
    • 5 Acres
    • $70,000 per Acre

    510 Callaway Estates Dr, Defiance, MO 63341

    Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

    Toni Dillon Trophy Properties & Auction

    510 Callaway Estates Dr, Defiance, MO 63341
  • 2 Patrick Ln, Defiance, MO 63341
    2 Patrick Ln, Defiance, MO 63341
    2 Patrick Ln, Defiance, MO 63341
    /82

    $750,000

    Open Sun 1PM - 3PM
    • 4 Beds
    • 4 Baths
    • 4,044 Sq Ft

    2 Patrick Ln, Defiance, MO 63341

    SPACE, ACREAGE & GARAGE GALORE! Nestled on just over 3 acres in desirable Defiance, this expansive 1.5-story home offers abundant living space, updates & the flexibility you've been looking for. The beautifully updated kitchen is a standout with white shaker cabinetry, solid-surface countertops, shiplap accents, pot-filler faucet, huge center island with built-in microwave drawer & breakfast bar,

    Cheryl Lade Coldwell Banker Realty - Gundaker

    2 Patrick Ln, Defiance, MO 63341
  • 0 Callaway Ridge Dr Unit MIS26057013, Defiance, MO 63341
    0 Callaway Ridge Dr Unit MIS26057013, Defiance, MO 63341
    0 Callaway Ridge Dr Unit MIS26057013, Defiance, MO 63341
    /11

    $899,946

    0 Callaway Ridge Dr Unit MIS26057013, Defiance, MO 63341

    This 29.9 acre parcel is an incredible opportunity to purchase your dream property to build your dream house or even as a land bank. The housing in area is absolutely beautiful and the area is so sought out. You may parcel land but not less than 5 acre. parcels. Road access is top notch and the land has been recently cleaned to make your viewing easy. So much potential and again a super nice

    Taylor Bailey Bailey Properties, Inc.

    0 Callaway Ridge Dr Unit MIS26057013, Defiance, MO 63341
  • 449 Stones Throw Ct, Defiance, MO 63341
    449 Stones Throw Ct, Defiance, MO 63341
    449 Stones Throw Ct, Defiance, MO 63341
    /4

    $420,800

    • Land
    • 5.26 Acres
    • $80,055 per Acre

    449 Stones Throw Ct, Defiance, MO 63341

    Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

    Stephen Kaiser Trophy Properties & Auction

    449 Stones Throw Ct, Defiance, MO 63341

Showing Results 1 - 40, Page 1 of 2

Missouri St. Charles County

Real Estate & Homes for Sale in Defiance, MO

Defiance, MO Home Prices

Defiance, MO
Median Home Price
$699,900
Median Sale Price
$705,000
+16% YoY
Avg. Price per Square Foot
$280
Median Single Family Price
$675,000
Total Active Listings
45 listings
Market Conditions
4 Months of Supply
Seller's Market

Frequently Asked Questions

What is the average home price in Defiance, MO?
Homes for sale in Defiance, MO have an average home price of $968,976.
How many homes have sold over the last 12 months in Defiance, MO?
55 homes have sold in Defiance, MO over the last 12 months.
What is the average household income in Defiance, MO?
The average household income in Defiance, MO is $104K.
What are the most popular zip codes in Defiance, MO?
The most popular zip codes in Defiance, MO include 63341, 63073, 63332, 63348 and 63005.
How much do you need to make to afford a house in Defiance?
The median home price in Defiance is $699,900. If you put a 20% down payment of $140,000 and had a 30-year fixed mortgage with an interest rate of 6.95%, your estimated principal and interest payment would be $3,710 a month plus property taxes, HOA fees, home insurance, PMI, and utilities. Using the 28% rule, you would need to make at least $159K a year to afford the median home price in Defiance. Learn how much home you can afford with our Home Affordability Calculator. The average household income in Defiance is $104K.
How are the schools in Defiance, MO?
Defiance, MO has highly rated public and private schools. Some of the best schools in Defiance based on Niche Grades are Francis Howell High School, Daniel Boone Elementary School and Francis Howell Middle School. Browse all the schools in Defiance, MO to learn more.
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