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Defiance, MO Homes for Sale

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  • /62

    $1,488,000

    • Land
    • 36 Acres
    • $41,576 per Acre

    300 Callaway Ridge Dr, Defiance, MO 63341

    Welcome to your private sanctuary on approx. 35.79 acres of serene, park-like grounds. This meticulously maintained 1.5-story home combines elegance and natural beauty. An updated kitchen features warm wood cabinetry, quartz counters, stainless appliances, and a cozy breakfast bar. The dining nook opens to the living room and a grand great room with tall ceilings, a fireplace, and expansive

    Suzanne Matyiko Berkshire Hathaway HomeServices Alliance Real Estate

    300 Callaway Ridge Dr, Defiance, MO 63341
  • /6

    $205,000

    • Land
    • 3.01 Acres
    • $68,106 per Acre

    121 Red Barn Ln, Defiance, MO 63341

    Your plans, your builder. Level, open lot with woods along the back line. The last unbuilt lot remaining. One of only (9) lots in Femme Osage Valley subdivision. Public water. Blacktop Streets. 10 minutes from Hwy 40/61.

    John Shaw Tom Shaw, REALTORS

    121 Red Barn Ln, Defiance, MO 63341
  • /63

    $875,000

    • 3 Beds
    • 4 Baths
    • 2,872 Sq Ft

    19 Jacks Cabin Dr, Defiance, MO 63341

    The same owner who custom built this showplace has lovingly maintained it for 30+ years & the pride of ownership is obvious. Professionally-designed lush irrigated landscaping wraps the home in beauty. 7 garage bays w/attic storage, including a detached 3 bay outbuilding w/500+ sq ft of usable attic space. Climate-controlled workshop w/air filtration. 3 acres of mature trees provide serenity &

    Chad Wilson Keller Williams Realty West

    19 Jacks Cabin Dr, Defiance, MO 63341
  • /16

    $485,000

    • 3 Beds
    • 2 Baths
    • 1,705 Sq Ft

    5 Wilderness Ln, Defiance, MO 63341

    Just imagine, a private home on 3 acres with a composite deck to enjoy the yard. Walking inside you find gleaming hardwood flooring. The family room has a wood burning fireplace with a circulating blower. Windows through the home have between-the-glass blinds to provide privacy. Kitchen boast a double oven. Many closets in the home have closet systems to provide for organization. Basement is

    Bradley Hanewinkel NextHome Simple Transitions

    5 Wilderness Ln, Defiance, MO 63341
  • /24

    $449,000

    • 4 Beds
    • 1 Bath
    • 1,321 Sq Ft

    130 Defiance Rd, Defiance, MO 63341

    Charming rustic farmhouse in excellent condition, nestled in the heart of downtown Defiance. This home offers stunning views of the Missouri River bottoms from the front porch, providing a serene and picturesque setting. Ideal for a short-term rental investment or as a cozy permanent residence. With its well-preserved character and prime location, this property offers both comfort and potential

    Tony Schulte MO Realty

    130 Defiance Rd, Defiance, MO 63341
  • /19

    $400,000

    • 2 Beds
    • 1 Bath
    • 1,728 Sq Ft

    112 Defiance Rd, Defiance, MO 63341

    A prime commercial space in the heart of downtown Defiance, featuring a beautifully renovated 1,728 sq ft building, formerly used as a kitchen and catering house. This property offers endless possibilities for various business ventures. The building boasts a poured foundation basement, providing ample storage space. Outdoors, you'll find a spacious pavilion with a stunning stone fireplace,

    Tony Schulte MO Realty

    112 Defiance Rd, Defiance, MO 63341
  • /46

    $575,000

    • 4 Beds
    • 3 Baths
    • 2,978 Sq Ft

    8 Lost Trails Dr, Defiance, MO 63341

    Discover your dream home in the exclusive Callaway Valley, a hidden gem in St. Charles County. This enchanting log cabin combines rustic charm with modern luxury on 3.6 wooded acres. Warm wood tones, exposed beams, and an open floor plan perfect for family living and entertaining. Updated kitchen with granite countertops and stainless steel appliances. Two cozy fireplaces. Spacious primary suite

    Suzanne Matyiko Berkshire Hathaway HomeServices Alliance Real Estate

    8 Lost Trails Dr, Defiance, MO 63341
  • /17

    $219,900

    • Land
    • 14 Acres
    • $15,378 per Acre

    0 Steeple Rock Unit MAR24075687, Defiance, MO 63341

    Beautiful building lot St. Charles County area of Defiance! All wooded with grand rock outcroppings and mature timber! Come build your dream home on the ridge overlooking the wooded valley and draws below. The drive coming down Callaway Fork Road is breathtaking as well. Where else in St. Charles County can you find 14+ Acres to call your own at this price and located in the Francis Howell School

    Eric Merchant Trophy Properties & Auction

    0 Steeple Rock Unit MAR24075687, Defiance, MO 63341
  • /18

    $975,000

    • Land
    • 30 Acres
    • $32,500 per Acre

    0 Callaway Ridge Dr Unit MAR24073648, Defiance, MO 63341

    Fabulous acreage for private estate or premier development land (cannot be subdivided less than 5 acre lots) on scenic Callaway Ridge Drive in Defiance! The land, approximately 30 acres, providing a spectacular view from the top, offers a combination of open land, with numerous home sites, and wooded land with timber. Along the road frontage is the peak of ridge top with level to sloping land.

    Catherine Shaw-Connely Tom Shaw, REALTORS

    0 Callaway Ridge Dr Unit MAR24073648, Defiance, MO 63341
  • /3

    $325,000

    • Land
    • 5.00 Acres
    • $65,000 per Acre

    1 Callaway Estates Drive Dr Unit 5 acres, Defiance, MO 63385

    Welcome to The Estates at Callaway Lake, an exclusive luxury subdivision nestled in the serene countryside of unincorporated Saint Charles County, Missouri. This prestigious community offers 108 breathtaking lots, ranging from 5 to 15 acres, providing the perfect canvas for your custom dream home. With a minimum build requirement of 2,400 sq. ft. and architectural approval, each estate combines

    Tom Shaw Tom Shaw, REALTORS

    1 Callaway Estates Drive Dr Unit 5 acres, Defiance, MO 63385
  • /5

    $684,320

    • Land
    • 26 Acres
    • $25,823 per Acre

    26 Callaway Ridge Dr, Defiance, MO 63341

    Discover your private oasis on this rare 26.5-acre parcel in the sought-after Callaway Valley Subdivision! Perfect for your dream home or personal estate, this expansive property offers serene seclusion amidst lush nature, with the flexibility to create up to four ideal building sites. Surrounded by custom homes on private roads and located within the highly regarded Francis Howell School

    Suzanne Matyiko Berkshire Hathaway HomeServices Alliance Real Estate

    26 Callaway Ridge Dr, Defiance, MO 63341
  • /14

    $149,900

    • Land
    • 3.29 Acres
    • $45,562 per Acre

    3600 Forest Edge Dr, Defiance, MO 63341

    Seize the chance to create your ideal sanctuary on this picturesque, fully wooded 3• -acre parcel, complete with a tranquil babbling brook meandering through. Nestled in the coveted Forest Lake Estate subdivision, this idyllic setting offers the perfect canvas for your dream home, surrounded by lush foliage and abundant wildlife. Just moments from renowned wine country, yet conveniently close to

    Vickie Hollenbeck-Barton Coldwell Banker Realty - Gundaker

    3600 Forest Edge Dr, Defiance, MO 63341
  • /14

    $311,150

    • Land
    • 9 Acres
    • $35,000 per Acre

    110 Steeple Point Dr Unit LOT 14, Defiance, MO 63341

    Feast your eyes on these jaw-dropping, stunning slices of paradise up for grabs! Picture this: lush, wooded lots with majestic, mature trees and underground electric waiting for your dreams to come alive. You’re just a stone's throw from fabulous wineries and other fun spots, yet far enough from the city to sip your morning coffee in blissful solitude. Your secret hideaway awaits! Two beautiful

    Sarah Bell Gold Bell Real Estate LLC

    110 Steeple Point Dr Unit LOT 14, Defiance, MO 63341
  • /14

    $177,100

    • Land
    • 5 Acres
    • $35,000 per Acre

    120 Steeple Point Dr Unit LOT 13, Defiance, MO 63341

    Feast your eyes on these jaw-dropping, stunning slices of paradise up for grabs! Picture this: lush, wooded lots with majestic, mature trees and underground electric waiting for your dreams to come alive. You’re just a stone's throw from fabulous wineries and other fun spots, yet far enough from the city to sip your morning coffee in blissful solitude. Your secret hideaway awaits! Two beautiful

    Sarah Bell Gold Bell Real Estate LLC

    120 Steeple Point Dr Unit LOT 13, Defiance, MO 63341
  • /14

    $176,750

    • Land
    • 5 Acres
    • $35,000 per Acre

    130 Steeple Point Dr Unit LOT 12, Defiance, MO 63341

    Feast your eyes on these jaw-dropping, stunning slices of paradise up for grabs! Picture this: lush, wooded lots with majestic, mature trees and underground electric waiting for your dreams to come alive. You’re just a stone's throw from fabulous wineries and other fun spots, yet far enough from the city to sip your morning coffee in blissful solitude. Your secret hideaway awaits! Two beautiful

    Sarah Bell Gold Bell Real Estate LLC

    130 Steeple Point Dr Unit LOT 12, Defiance, MO 63341
  • /14

    $179,550

    • Land
    • 5 Acres
    • $35,000 per Acre

    150 Steeple Point Dr Unit LOT 10, Defiance, MO 63341

    Feast your eyes on these jaw-dropping, stunning slices of paradise up for grabs! Picture this: lush, wooded lots with majestic, mature trees and underground electric waiting for your dreams to come alive. You’re just a stone's throw from fabulous wineries and other fun spots, yet far enough from the city to sip your morning coffee in blissful solitude. Your secret hideaway awaits! Two beautiful

    Sarah Bell Gold Bell Real Estate LLC

    150 Steeple Point Dr Unit LOT 10, Defiance, MO 63341
  • /14

    $180,950

    • Land
    • 5 Acres
    • $35,000 per Acre

    160 Steeple Point Dr Unit LOT 9, Defiance, MO 63341

    Feast your eyes on these jaw-dropping, stunning slices of paradise up for grabs! Picture this: lush, wooded lots with majestic, mature trees and underground electric waiting for your dreams to come alive. You’re just a stone's throw from fabulous wineries and other fun spots, yet far enough from the city to sip your morning coffee in blissful solitude. Your secret hideaway awaits! Two beautiful

    Sarah Bell Gold Bell Real Estate LLC

    160 Steeple Point Dr Unit LOT 9, Defiance, MO 63341
  • /14

    $176,050

    • Land
    • 5 Acres
    • $35,000 per Acre

    180 Steeple Point Dr Unit LOT 7, Defiance, MO 63341

    Feast your eyes on these jaw-dropping, stunning slices of paradise up for grabs! Picture this: lush, wooded lots with majestic, mature trees and underground electric waiting for your dreams to come alive. You’re just a stone's throw from fabulous wineries and other fun spots, yet far enough from the city to sip your morning coffee in blissful solitude. Your secret hideaway awaits! Two beautiful

    Sarah Bell Gold Bell Real Estate LLC

    180 Steeple Point Dr Unit LOT 7, Defiance, MO 63341
  • /14

    $375,200

    • Land
    • 11 Acres
    • $35,000 per Acre

    190 Steeple Point Dr Unit LOT 6, Defiance, MO 63341

    Feast your eyes on these jaw-dropping, stunning slices of paradise up for grabs! Picture this: lush, wooded lots with majestic, mature trees and underground electric waiting for your dreams to come alive. You’re just a stone's throw from fabulous wineries and other fun spots, yet far enough from the city to sip your morning coffee in blissful solitude. Your secret hideaway awaits! Two beautiful

    Sarah Bell Gold Bell Real Estate LLC

    190 Steeple Point Dr Unit LOT 6, Defiance, MO 63341
  • /2

    $115,000

    • Land
    • 7 Acres
    • $16,429 per Acre

    0 Steeple Rock Unit MAR25019055, Defiance, MO 63341

    Beautiful building lot St. Charles County area of Defiance! All wooded with grand rock outcroppings and mature timber! Come build your dream home on the ridge overlooking the wooded valley and draws below. The drive coming down Callaway Fork Road is breathtaking as well. Where else in St. Charles County can you find 7+ Acres to call your own at this price and located in the Francis Howell School

    Eric Merchant Trophy Properties & Auction

    0 Steeple Rock Unit MAR25019055, Defiance, MO 63341
  • /2

    $135,000

    • Land
    • 7 Acres
    • $19,286 per Acre

    0 Steeple Rock Unit MAR25019015, Defiance, MO 63341

    Beautiful building lot St. Charles County area of Defiance! All wooded with grand rock outcroppings and mature timber! Come build your dream home on the ridge overlooking the wooded valley and draws below. The drive coming down Callaway Fork Road is breathtaking as well. Where else in St. Charles County can you find 7+ Acres to call your own at this price and located in the Francis Howell School

    Eric Merchant Trophy Properties & Auction

    0 Steeple Rock Unit MAR25019015, Defiance, MO 63341
  • /43

    $425,000 Open House 5/10

    • 3 Beds
    • 3 Baths
    • 1,669 Sq Ft

    149 Old Colony Rd, Defiance, MO 63341

    Welcome to 149 Old Colony - a beautifully updated home nestled in Defiance, just minutes from the Katy Trail & renowned wineries! Located in the highly sought-after Francis Howell & Daniel Boone Elementary attendance area, this versatile property offers a spacious main floor featuring a primary suite, two additional bedrooms, another full bath, dedicated office & a large laundry room with extra

    Jeremy Barrett Keller Williams Realty West

    149 Old Colony Rd, Defiance, MO 63341
  • /48

    $740,000 Open Sun 12PM - 2PM

    • 5 Beds
    • 4.5 Baths
    • 4,140 Sq Ft

    3856 Rooster Ridge Ln, Defiance, MO 63341

    Prepare to be WOWED! Impressive 1.5 story on a 3.2 AC, wooded lot for nature-loving buyers who enjoy the outdoors. This peaceful setting creates a picturesque back-drop for an amazing home. The ext is impressive w/brick, 4 bay windows, 3 car gar, arch shingles (1 yr old), leaded glass door and a large front porch. Features inc 4,140 s/f of living space, 5 BD, 4.5 BA, 2 story Grt Rm w/window wall,

    Kelly Boehmer Berkshire Hathaway HomeServices Select Properties

    3856 Rooster Ridge Ln, Defiance, MO 63341

About Defiance

The gateway to Missouri wine country begins in the green hills of Defiance. Not actually a city, Defiance is an unincorporated community in southwest St. Charles County, where farms, vineyards and pastoral estates are spread among the sparsely populated region of 3,200 residents.

Though residential construction is spilling into the area from other parts of the county, a defining factor of Defiance real estate remains the expansive lots that homes sit on, which Lauderdale Realty owner Dan Lauderdale says typically are 5 acres or larger, thou ...

Frequently Asked Questions

What is the average home price in Defiance, MO?
Homes for sale in Defiance, MO have an average home price of $733,141.
Are home prices dropping in Defiance?
Yes, home prices in Defiance are down 17% in the last 12 months.
How many homes have sold over the last 12 months in Defiance, MO?
38 homes have sold in Defiance, MO over the last 12 months.
What are the most popular zip codes in Defiance, MO?
The most popular zip codes in Defiance, MO include 63385, 63366, 63348, 63368 and 63301.
How much do you need to make to afford a house in Defiance?
The median home price in Defiance is $625,000. If you put a 20% down payment of $125,000 and had a 30-year fixed mortgage with an interest rate of 6.81%, your estimated principal and interest payment would be $3,260 a month plus property taxes, HOA fees, home insurance, PMI, and utilities. Using the 28% rule, you would need to make at least $140K a year to afford the median home price in Defiance.
How are the schools in Defiance, MO?
Defiance, MO has highly rated public and private schools. Some of the best schools in Defiance based on Niche Grades are Francis Howell High School, Daniel Boone Elementary School and Francis Howell Middle School. Browse all the schools in Defiance, MO to learn more.

Home Trends in Defiance, MO

Home Trends

Median Price (12 Mo)
$626,500
Median Single Family Price
$625,000
Average Price Per Sq Ft
$246
Number of Homes for Sale
8
Last 12 months Home Sales
38
Months of Supply
2.50
Median List Price
$625,000
Median Discount From 1st List Price
2%
Median Home Sale Price YoY Change
-3%
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