49

Newest Homes for Sale in Defiance, MO

Section Image Section Image
  • 44 Wilderness Ln, Defiance, MO 63341
    44 Wilderness Ln, Defiance, MO 63341
    44 Wilderness Ln, Defiance, MO 63341
    /49

    $625,000

    Open Sun 1PM - 3PM
    • 4 Beds
    • 2.5 Baths
    • 2,096 Sq Ft

    44 Wilderness Ln, Defiance, MO 63341

    Tucked away at the end of a cul-de-sac and lined by trees on a gorgeous 3 acre lot this lovely, private hideaway is calling you home to a welcoming 2 story gem, Woodworking Shop or She shed, Barn and pasture. Enter to ceramic tile entry, coat closet and powder room. Grand staircase in entry with wood rails and wrought iron balusters. Large L shaped great room with solid oak floors and wood stove.

    Mike Simms Worth Clark Realty

    44 Wilderness Ln, Defiance, MO 63341
  • 769 Old Colony Rd, Defiance, MO 63341
    769 Old Colony Rd, Defiance, MO 63341
    769 Old Colony Rd, Defiance, MO 63341
    /56

    $850,000

    Open Sun 1PM - 3PM
    • 5 Beds
    • 5.5 Baths
    • 4,749 Sq Ft

    769 Old Colony Rd, Defiance, MO 63341

    Experience refined country living in the heart of Missouri wine country at this stunning custom-built brick atrium ranch in Defiance. Nestled on approximately 5 picturesque acres, this exceptional estate offers nearly 5,000 square feet of beautifully finished living space designed for both luxury and comfort. Step inside and be captivated by the dramatic atrium wall of windows that floods the

    Lori Dillick Coldwell Banker Realty - Gundaker

    769 Old Colony Rd, Defiance, MO 63341
  • 3077 S Missouri 94, Defiance, MO 63341
    3077 S Missouri 94, Defiance, MO 63341
    /2

    $305,000

    • Land
    • 5.03 Acres
    • $60,636 per Acre

    3077 S Missouri 94, Defiance, MO 63341

    Rare opportunity to own 5.03 acres overlooking the Missouri River Valley just outside the heart of Defiance. Enjoy sweeping sunrise views, a private setting, and plenty of usable yard space for a custom home, outdoor living, gardens, or additional structures. A private lane provides direct access to Hwy 94 while maintaining a peaceful setting. The existing clearing offers an excellent homesite

    Meyer Auctions Meyer & Company Real Estate and Auctions

    3077 S Missouri 94, Defiance, MO 63341
  • 115 Markham Trail Ln, Defiance, MO 63341
    115 Markham Trail Ln, Defiance, MO 63341
    115 Markham Trail Ln, Defiance, MO 63341
    /44

    $1,430,000

    $69K PRICE DROP Pending
    • 4 Beds
    • 3.5 Baths
    • 4,461 Sq Ft

    115 Markham Trail Ln, Defiance, MO 63341

    Looking for the perfect multi-generational home or private in-law suite with its own entrance? This custom-built Lombardo Ranch on 5.44 acres checks every box. Thoughtfully designed with high-end upgrades throughout, this home blends style, comfort, and function in every detail.On the main level, you’ll find a chef’s kitchen featuring white custom cabinetry, quartz countertops, a striking

    Madison Lantz Berkshire Hathaway HomeServices Select Properties

    115 Markham Trail Ln, Defiance, MO 63341
  • 3901 Highway D, Defiance, MO 63341
    3901 Highway D, Defiance, MO 63341
    3901 Highway D, Defiance, MO 63341
    /32

    $379,950

    • 3 Beds
    • 1 Bath
    • 1,296 Sq Ft

    3901 Highway D, Defiance, MO 63341

    Ranch style, full brick home situated on 4.6 acres with an attached one car garage. The home has 3 bedrooms, 1 bath, 1296 square feet, some hardwood floors, and a full basement situated on a fairly level lot. Some photos are virtually staged.

    Michelle Syberg Mid America Property Partners

    3901 Highway D, Defiance, MO 63341
  • 4075 Highway D, Defiance, MO 63341
    4075 Highway D, Defiance, MO 63341
    4075 Highway D, Defiance, MO 63341
    /87

    $950,000

    • 4 Beds
    • 5 Baths
    • 4,298 Sq Ft

    4075 Highway D, Defiance, MO 63341

    Luxury country living meets everyday convenience on this exceptional 10 unrestricted acre estate! Perfectly situated just minutes from Highway 40/61, Highway N, Winghaven shopping, New Melle, Augusta, and Defiance, you’ll enjoy the peace and privacy of country living while remaining close to award-winning wineries, restaurants, shopping, and an easy commute.Beautifully updated and

    Agent Photo

    Samantha Richardson

    Main St. Real Estate

    4075 Highway D, Defiance, MO 63341
  • 220 Northlind Dr, Defiance, MO 63341
    220 Northlind Dr, Defiance, MO 63341
    220 Northlind Dr, Defiance, MO 63341
    /79

    $1,400,000

    • 5 Beds
    • 7 Baths
    • 6,521 Sq Ft

    220 Northlind Dr, Defiance, MO 63341

    Stunning brick and stone ranch-style home sitting on 3 private acres surrounded by mature trees and scenic views! This custom-built home boasts 5 bedrooms, 4 full bathrooms, 3 half bathrooms, and over 6,500 square feet of living space including the finished walkout lower level. The property also features an attached 3 car garage and a detached 52 x 40 foot detached garage with a bonus room. The

    Mark Gellman EXP Realty, LLC

    220 Northlind Dr, Defiance, MO 63341
  • 3077 Highway 94 S, Defiance, MO 63341
    3077 Highway 94 S, Defiance, MO 63341
    3077 Highway 94 S, Defiance, MO 63341
    /25

    $305,000

    $20K PRICE DROP
    • Land
    • 5.03 Acres
    • $60,636 per Acre

    3077 Highway 94 S, Defiance, MO 63341

    Rare opportunity to own 5.03 acres overlooking the Missouri River Valley just outside the heart of Defiance. Enjoy sweeping sunrise views, a private setting, and plenty of usable yard space for a custom home, outdoor living, gardens, or additional structures. A private lane provides direct access to Hwy 94 while maintaining a peaceful setting. The existing clearing offers an excellent homesite

    Sherry Ruyle Meyer & Company Real Estate

    3077 Highway 94 S, Defiance, MO 63341
  • 3877 Highway D, Defiance, MO 63341
    3877 Highway D, Defiance, MO 63341
    3877 Highway D, Defiance, MO 63341
    /37

    $535,000

    $14K PRICE DROP
    • 3 Beds
    • 2 Baths
    • 1,600 Sq Ft

    3877 Highway D, Defiance, MO 63341

    Spacious ranch on 6 gorgeous acres conveniently located just minutes from wineries, schools, shopping and highways! This charming 3 bedroom, 2 bath home comes complete with main floor laundry, full, unfinished basement, and a primary bedroom with walk-in closet and ensuite bath. Besides the 2-car attached garage, there is a 28’x60’ insulated metal outbuilding with concrete floor, electric and 220

    Sherry Raleigh-Adams Wolfe Realty

    3877 Highway D, Defiance, MO 63341
  • 460 Highway Dd, Defiance, MO 63341
    460 Highway Dd, Defiance, MO 63341
    460 Highway Dd, Defiance, MO 63341
    /66

    $719,900

    Pending
    • 4 Beds
    • 3.5 Baths
    • 3,400 Sq Ft

    460 Highway Dd, Defiance, MO 63341

    Set on 3.05 private wooded acres, this custom atrium ranch lands in the sweet spot between the St. Louis and St. Charles corridors and Missouri wine country, an easy drive either direction. Inside and out, it offers what buyers rarely find: room to spread out, work, and entertain without compromise. The garage space here is genuinely rare. An attached oversized 3-car handles everyday vehicles

    Kyle Weindel Nettwork Global

    460 Highway Dd, Defiance, MO 63341
  • 2540 S Highway 94, Defiance, MO 63341
    2540 S Highway 94, Defiance, MO 63341
    2540 S Highway 94, Defiance, MO 63341
    /10

    $499,900

    Under Contract
    • 3 Beds
    • 2.5 Baths
    • 1,978 Sq Ft

    2540 S Highway 94, Defiance, MO 63341

    Country living on 5.21+/- level STUNNING acres in unincorporated Defiance! A tree lined driveway leads to a CHARMING, RANCH home with 3 bedrooms, 2.5 baths & 1,978+/- SqFt of living space that offers an AWESOME, 30’ x 24’, 2-car, detached garage & shed. Partially covered front porch greets you as you step inside the entry foyer. Step down, living room boasts a floor-to-ceiling brick wood burning

    Catherine Shaw-Connely Tom Shaw, REALTORS

    2540 S Highway 94, Defiance, MO 63341
  • 79 Wilderness Ln, Defiance, MO 63341
    79 Wilderness Ln, Defiance, MO 63341
    79 Wilderness Ln, Defiance, MO 63341
    /65

    $542,400

    $8K PRICE DROP Pending
    • 4 Beds
    • 2.5 Baths
    • 3,372 Sq Ft

    79 Wilderness Ln, Defiance, MO 63341

    Tucked away on 3 wooded acres, this meticulously maintained 4-bedroom, 2.5-bath home offers over 2,600 sq ft of comfortable living space, combining privacy, functionality, and stylish updates.The main floor is filled with natural light and features a spacious primary suite with walk-in closets, convenient main-floor laundry, a separate dining room, and a flexible front living room/office. The

    Rachel Hirth Avenue Real Estate Group

    79 Wilderness Ln, Defiance, MO 63341
  • 2 Woodridge Dr, Defiance, MO 63341
    2 Woodridge Dr, Defiance, MO 63341
    2 Woodridge Dr, Defiance, MO 63341
    /58

    $795,000

    • 4 Beds
    • 3.5 Baths
    • 4,564 Sq Ft

    2 Woodridge Dr, Defiance, MO 63341

    This handsome and spacious 4 bedroom 4 bath ranch home is beautifully situated on a 3 acre lot surrounded by mature trees creating a private, peaceful oasis for relaxing and entertaining. The recently refinished wide-plank hardwood floors are simply outstanding. A large living/family room with fireplace leads to an outdoor brick terrace overlooking the salt water pool with waterfall. The custom

    John Zarky Janet McAfee Inc.

    2 Woodridge Dr, Defiance, MO 63341
  • 7 Wilderness Ln, Defiance, MO 63341
    7 Wilderness Ln, Defiance, MO 63341
    7 Wilderness Ln, Defiance, MO 63341
    /73

    $489,000

    Pending
    • 3 Beds
    • 2 Baths
    • 2,156 Sq Ft

    7 Wilderness Ln, Defiance, MO 63341

    Hard to Find Log Cabin on 3 very usable Acres in the Heart of Defiance! Get ready to unleash your inner explorer at 7 Wilderness Lane. Built in 1978, this charming single-family lob cabin-type home is more than just a residence—it’s your gateway to adventure and peaceful country living. Inside, you’ll find three cozy bedrooms and two full bathrooms, thoughtfully designed for everyday comfort and

    Sandi Alexander RE/MAX EDGE

    7 Wilderness Ln, Defiance, MO 63341
  • 2210 S Highway 94, Defiance, MO 63341
    2210 S Highway 94, Defiance, MO 63341
    2210 S Highway 94, Defiance, MO 63341
    /24

    $349,900

    Pending
    • 3 Beds
    • 2 Baths
    • 1,718 Sq Ft

    2210 S Highway 94, Defiance, MO 63341

    This PERFECT homesteader property, RIGHT OFF South HWY 94, features 1+/- level acres with 1,718+/- SqFt ranch FULL brick home, 2-car attached garage & 1-car detached garage! CHARMING 3 bedroom & 2 full bath home. Covered front porch greets you as you step inside. Mostly carpet flooring throughout. Living room boasts a wall of windows & French door entry to Dining room with a glass door walk-out

    Catherine Shaw-Connely Tom Shaw, REALTORS

    2210 S Highway 94, Defiance, MO 63341
  • 4325 Hueffmeier Rd, Defiance, MO 63341
    4325 Hueffmeier Rd, Defiance, MO 63341
    4325 Hueffmeier Rd, Defiance, MO 63341
    /99

    $1,690,000

    $100K PRICE DROP
    • 4 Beds
    • 3.5 Baths
    • 5,609 Sq Ft

    4325 Hueffmeier Rd, Defiance, MO 63341

    Welcome home to this beautifully appointed brick ranch that truly has it all—inside and out. Situated on approximately 10+/- acres, this property offers the perfect blend of privacy, space, and resort-style living. Step into your own private backyard retreat featuring a stunning in-ground saltwater pool (9.5 ft deep), complete with heating and cooling for extended seasonal enjoyment. The

    Scott Dyer MO Realty

    4325 Hueffmeier Rd, Defiance, MO 63341
  • 20 + - Ac Highway D, Defiance, MO 63341
    20 + - Ac Highway D, Defiance, MO 63341
    20 + - Ac Highway D, Defiance, MO 63341
    /16

    $840,000

    • Land
    • 20 Acres
    • $42,000 per Acre

    20 + - Ac Highway D, Defiance, MO 63341

    Stunning 20 Acre Rural Retreat Endless Possibilities Await! Discover the beauty and serenity of this 20-acre gem in the heart of nature! Nestled in the highly sought-after Francis Howell School District, this picturesque property offers rolling hills, open fields, and scattered wooded areas, creating the perfect blend of open space and privacy. A scenic creek meanders through the landscape,

    Eric Merchant Trophy Properties and Auction

    20 + - Ac Highway D, Defiance, MO 63341
  • 82 + - Ac Highway D, Defiance, MO 63341
    82 + - Ac Highway D, Defiance, MO 63341
    82 + - Ac Highway D, Defiance, MO 63341
    /23

    $2,911,000

    • Land
    • 82 Acres
    • $35,500 per Acre

    82 + - Ac Highway D, Defiance, MO 63341

    Stunning 82+/- Acre Rural Retreat Endless Possibilities Await! Discover the beauty and serenity of this gem in the heart of nature! Nestled in the highly sought-after Francis Howell School District, this picturesque property offers rolling hills, open fields, and scattered wooded areas, creating the perfect blend of open space and privacy. A scenic creek meanders through the landscape, adding to

    Eric Merchant Trophy Properties and Auction

    82 + - Ac Highway D, Defiance, MO 63341
  • 7 Walnut Ridge Ct, Defiance, MO 63341
    7 Walnut Ridge Ct, Defiance, MO 63341
    7 Walnut Ridge Ct, Defiance, MO 63341
    /71

    $650,000

    • 4 Beds
    • 3 Baths
    • 3,546 Sq Ft

    7 Walnut Ridge Ct, Defiance, MO 63341

    Nestled on a breathtaking and private 3-acre lot in the heart of Defiance, this beautifully updated ranch home offers the perfect blend of tranquility, comfort, and convenience. With 4 bedrooms, 3 full baths, and over 3,500 square feet of thoughtfully designed living space, this home feels like your own secluded retreat among the trees. From the moment you step into the foyer, you'll be

    Julie Moran Coldwell Banker Realty - Gundaker

    7 Walnut Ridge Ct, Defiance, MO 63341
  • 513 Callaway Estates Dr, Defiance, MO 63341
    513 Callaway Estates Dr, Defiance, MO 63341
    513 Callaway Estates Dr, Defiance, MO 63341
    /4

    $350,000

    Under Contract
    • Land
    • 5 Acres
    • $70,000 per Acre

    513 Callaway Estates Dr, Defiance, MO 63341

    Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 already sold in the first 18

    Toni Dillon Trophy Properties & Auction

    513 Callaway Estates Dr, Defiance, MO 63341
  • 503 Callaway Estates Dr, Defiance, MO 63341
    503 Callaway Estates Dr, Defiance, MO 63341
    503 Callaway Estates Dr, Defiance, MO 63341
    /4

    $350,000

    Under Contract
    • Land
    • 5 Acres
    • $70,000 per Acre

    503 Callaway Estates Dr, Defiance, MO 63341

    Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 already sold in the first 18

    Toni Dillon Trophy Properties & Auction

    503 Callaway Estates Dr, Defiance, MO 63341
  • 800 Matson Hill Rd, Defiance, MO 63341
    800 Matson Hill Rd, Defiance, MO 63341
    800 Matson Hill Rd, Defiance, MO 63341
    /53

    $649,900

    • 4 Beds
    • 3 Baths
    • 2,479 Sq Ft

    800 Matson Hill Rd, Defiance, MO 63341

    Nestled on 8+ scenic acres off coveted Matson Hill Road in Unincorporated St. Charles County, this meticulously maintained retreat offers the perfect blend of refined comfort and peaceful country living. Surrounded by mature trees, wildlife, and nature, this stunning property delivers privacy without sacrificing convenience. Welcoming foyer opens to formal living and dining rooms before leading

    Suzanne Matyiko ReeceNichols Real Estate

    800 Matson Hill Rd, Defiance, MO 63341
  • 0 Defiance Rd Unit MIS26025560, Defiance, MO 63341
    0 Defiance Rd Unit MIS26025560, Defiance, MO 63341
    /2

    $425,000

    • Land
    • 8.5 Acres
    • $50,000 per Acre

    0 Defiance Rd Unit MIS26025560, Defiance, MO 63341

    8.5+/- Fabulous acres that offer a combination of open land, level to rolling hills, wooded land & access to a shared pond. Rare opportunity to own this beautiful, very scenic acreage. The perfect place for an equestrian homestead, a country estate, contemporary farmhouse or your DREAM development. This acreage offers seclusion, country style living, with an abundant wildlife habitat for the avid

    Catherine Shaw-Connely Tom Shaw, REALTORS

    0 Defiance Rd Unit MIS26025560, Defiance, MO 63341
  • 517 Callaway Estates Dr, Defiance, MO 63341
    517 Callaway Estates Dr, Defiance, MO 63341
    517 Callaway Estates Dr, Defiance, MO 63341
    /4

    $350,000

    • Land
    • 5 Acres
    • $70,000 per Acre

    517 Callaway Estates Dr, Defiance, MO 63341

    Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

    Stephen Kaiser Trophy Properties & Auction

    517 Callaway Estates Dr, Defiance, MO 63341
  • 449 Stones Throw Ct, Defiance, MO 63341
    449 Stones Throw Ct, Defiance, MO 63341
    449 Stones Throw Ct, Defiance, MO 63341
    /4

    $420,800

    • Land
    • 5.26 Acres
    • $80,055 per Acre

    449 Stones Throw Ct, Defiance, MO 63341

    Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

    Stephen Kaiser Trophy Properties & Auction

    449 Stones Throw Ct, Defiance, MO 63341
  • 831 Old Colony Rd, Defiance, MO 63341
    831 Old Colony Rd, Defiance, MO 63341
    831 Old Colony Rd, Defiance, MO 63341
    /38

    $509,000

    New Construction Under Contract
    • 2 Beds
    • 3 Baths
    • 1,850 Sq Ft

    831 Old Colony Rd, Defiance, MO 63341

    Charming country home on 2 unrestricted acres. No HOA. 6 years old. Completely move in ready. 4 minutes from the Katy trail. 4 minutes from Defiance Ridge Vineyards and a short drive to many other venues. This private and peaceful property features hardwood floors, large porches in the front and rear with ceiling fans. New granite countertops, with farmhouse sink, beautiful backsplash and under

    Jonathan Minerick HomeCoin.com

    831 Old Colony Rd, Defiance, MO 63341
  • 353 Callaway Ridge (25 5) Dr, Defiance, MO 63341
    353 Callaway Ridge (25 5) Dr, Defiance, MO 63341
    353 Callaway Ridge (25 5) Dr, Defiance, MO 63341
    /69

    $2,375,000

    • 3 Beds
    • 4.5 Baths
    • 4,037 Sq Ft

    353 Callaway Ridge (25 5) Dr, Defiance, MO 63341

    Experience the ultimate in privacy and natural beauty with this stunning custom waterfront property nestled on 25.5+/- mostly wooded acres with frontage on the serene waters of Callaway Valley Lake. Crafted with exceptional attention to detail, this one-of-a-kind property showcases rich woodwork and impeccable craftsmanship throughout. Highlighted by a grand wood-paneled ceiling with softly

    Kelly Beanblossom-Schlake Blondin Group, Inc

    353 Callaway Ridge (25 5) Dr, Defiance, MO 63341
  • 1510 Highway Dd, Defiance, MO 63341
    1510 Highway Dd, Defiance, MO 63341
    1510 Highway Dd, Defiance, MO 63341
    /40

    $625,000

    $25K PRICE DROP
    • 5 Beds
    • 3 Baths
    • 3,391 Sq Ft

    1510 Highway Dd, Defiance, MO 63341

    Welcome to 1510 Highway DD in unincorporated St. Charles County and in the Francis Howell School District. Nestled on 3 beautiful acres in St. Charles County, this rare 5 bedroom ranch offers the perfect blend of peaceful living while keeping you just minutes from shopping, restaurants, and major highways. Step inside to find an expansive open layout where the kitchen is a true centerpiece,

    Timothy Koppel Berkshire Hathaway HomeServices Select Properties

    1510 Highway Dd, Defiance, MO 63341
  • 2461 Highway F, Defiance, MO 63341
    2461 Highway F, Defiance, MO 63341
    /2

    $449,900

    $35K PRICE DROP
    • Land
    • 9.05 Acres
    • $49,713 per Acre

    2461 Highway F, Defiance, MO 63341

    This mostly level 9.05 Acres of land includes a well with a solar-powered pump and five frost-free spigots on the southeast side—perfect for gardens, orchards, or hobby farming. A gravel driveway has already been added along the south side for convenient access. Only a small portion of the front is in the 100-year floodplain, while the majority of the property sits outside of it, giving you

    Catherine Shaw-Connely Tom Shaw, REALTORS

    2461 Highway F, Defiance, MO 63341
  • 28 Meditation Way, Defiance, MO 63341
    28 Meditation Way, Defiance, MO 63341
    28 Meditation Way, Defiance, MO 63341
    /4

    $334,200

    Under Contract
    • Land
    • 5.57 Acres
    • $60,000 per Acre

    28 Meditation Way, Defiance, MO 63341

    Nestled in the heart of St. Charles County in Defiance and near New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 lots already sold in the first

    Toni Dillon Trophy Properties & Auction

    28 Meditation Way, Defiance, MO 63341
  • 36 Meditation Way, Defiance, MO 63341
    36 Meditation Way, Defiance, MO 63341
    36 Meditation Way, Defiance, MO 63341
    /4

    $318,600

    Under Contract
    • Land
    • 5.31 Acres
    • $60,000 per Acre

    36 Meditation Way, Defiance, MO 63341

    Nestled in the heart of St. Charles County in Defiance and near New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 lots already sold in the first

    Toni Dillon Trophy Properties & Auction

    36 Meditation Way, Defiance, MO 63341
  • 1451 Highway F, Defiance, MO 63341
    1451 Highway F, Defiance, MO 63341
    1451 Highway F, Defiance, MO 63341
    /43

    $679,900

    $20K PRICE DROP
    • 3 Beds
    • 2.5 Baths
    • 1,944 Sq Ft

    1451 Highway F, Defiance, MO 63341

    Rarely does an opportunity like this come available in Defiance! Located in the beautiful Femme Osage valley, nestled on 9+ picturesque acres, this 3 bed, 2.5 home offers the perfect blend of privacy, space, and comfort. The setting is rural but convenient to highway 64/40, Chesterfield, Wentzville, and Francis Howell schools. Step inside to find hardwood floors throughout the main level, leading

    Matthew Lauman Magnolia Real Estate

    1451 Highway F, Defiance, MO 63341
  • 215 Rugged Acres Ln, Defiance, MO 63341
    215 Rugged Acres Ln, Defiance, MO 63341
    215 Rugged Acres Ln, Defiance, MO 63341
    /18

    $650,000

    Open Sun 12PM - 2PM
    • 3 Beds
    • 2 Baths
    • 2,013 Sq Ft

    215 Rugged Acres Ln, Defiance, MO 63341

    Custom built, beautifully crafted home with over 2,000 sq feet of living space with luxury finishes. Located on 5 unrestricted acres, mostly wooded, outside New Melle in the heart of wine country. Private and peacefully located with access to major roads, living in country with easy access to all modern conveniences. Stepping Inside you are greeted with soaring 10' ceilings, open floor plan from

    Dolly Sjoholm Call Dolly, LLC

    215 Rugged Acres Ln, Defiance, MO 63341
  • 50 Sunfish Dr, Defiance, MO 63341
    50 Sunfish Dr, Defiance, MO 63341
    50 Sunfish Dr, Defiance, MO 63341
    /45

    $899,999

    $50K PRICE DROP
    • 4 Beds
    • 4.5 Baths
    • 4,579 Sq Ft

    50 Sunfish Dr, Defiance, MO 63341

    Experience the best of Callaway Valley living—where privacy, luxury, and lifestyle align.Situated on a stunning 6-acre estate with coveted lake rights, this exceptional property offers a rare blend of space, serenity, and high-end living.The heart of the home is a chef’s dream kitchen, beautifully updated in 2022 with a 48” Wolf gas range with pot filler, Sub-Zero refrigerator, expansive

    Agent Photo

    Amanda Alejandro

    Realty Shop

    50 Sunfish Dr, Defiance, MO 63341
  • 4 Cooper's Ct, Defiance, MO 63341
    4 Cooper's Ct, Defiance, MO 63341
    4 Cooper's Ct, Defiance, MO 63341
    /4

    $587,000

    • Land
    • 5.87 Acres
    • $100,000 per Acre

    4 Cooper's Ct, Defiance, MO 63341

    Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

    Toni Dillon Trophy Properties & Auction

    4 Cooper's Ct, Defiance, MO 63341
  • 12 Still Waters Ct, Defiance, MO 63341
    12 Still Waters Ct, Defiance, MO 63341
    12 Still Waters Ct, Defiance, MO 63341
    /4

    $350,000

    • Land
    • 5 Acres
    • $70,000 per Acre

    12 Still Waters Ct, Defiance, MO 63341

    Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

    Toni Dillon Trophy Properties & Auction

    12 Still Waters Ct, Defiance, MO 63341
  • 510 Callaway Estates Dr, Defiance, MO 63341
    510 Callaway Estates Dr, Defiance, MO 63341
    510 Callaway Estates Dr, Defiance, MO 63341
    /4

    $350,000

    • Land
    • 5 Acres
    • $70,000 per Acre

    510 Callaway Estates Dr, Defiance, MO 63341

    Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

    Toni Dillon Trophy Properties & Auction

    510 Callaway Estates Dr, Defiance, MO 63341
  • 3840 Rooster Ridge Ln, Defiance, MO 63341
    3840 Rooster Ridge Ln, Defiance, MO 63341
    3840 Rooster Ridge Ln, Defiance, MO 63341
    /62

    $725,000

    Open Sun 2PM - 3PM $50K PRICE DROP
    • 3 Beds
    • 3.5 Baths
    • 5,601 Sq Ft

    3840 Rooster Ridge Ln, Defiance, MO 63341

    LOCATION is perfection! Travel down a paved road and arrive at your custom ranch home, with double garages, a finished basement, stunning seller/builder details with over 5,000 total finished SF! I need way more space here to describe all of the features. Large kitchen with second dining / living area arranged around the Buck stove fireplace. Brazilian cherry flooring, double wall ovens, long

    Agent Photo

    Hope Fick

    Sage Property Group, LLC

    3840 Rooster Ridge Ln, Defiance, MO 63341
  • 180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341
    180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341
    180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341
    /4

    $151,000

    • Land
    • 5.03 Acres
    • $30,020 per Acre

    180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341

    Awesome lot available in a rural subdivision

    Dan Lauderdale Lauderdale Realty

    180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341
  • 130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341
    130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341
    130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341
    /9

    $151,000

    • Land
    • 5.05 Acres
    • $29,901 per Acre

    130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341

    Great Building Lot. Schedule an appointment and view this property today.

    Dan Lauderdale Lauderdale Realty

    130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341

Showing Results 1 - 40, Page 1 of 2

Missouri St. Charles County Defiance

Newest Listings for Sale in Defiance, MO

Frequently Asked Questions

What is the average home price in Defiance, MO?
Homes for sale in Defiance, MO have an average home price of $928,516.
How many homes have sold over the last 12 months in Defiance, MO?
54 homes have sold in Defiance, MO over the last 12 months.
What is the average household income in Defiance, MO?
The average household income in Defiance, MO is $104K.
What are the most popular zip codes in Defiance, MO?
The most popular zip codes in Defiance, MO include 63341, 63073, 63005, 63332 and 63348.
How much do you need to make to afford a house in Defiance?
The median home price in Defiance is $765,000. If you put a 20% down payment of $153,000 and had a 30-year fixed mortgage with an interest rate of 6.49%, your estimated principal and interest payment would be $3,860 a month plus property taxes, HOA fees, home insurance, PMI, and utilities. Using the 28% rule, you would need to make at least $165K a year to afford the median home price in Defiance. Learn how much home you can afford with our Home Affordability Calculator. The average household income in Defiance is $104K.
How are the schools in Defiance, MO?
Defiance, MO has highly rated public and private schools. Some of the best schools in Defiance based on Niche Grades are Francis Howell High School, Daniel Boone Elementary School and Francis Howell Middle School. Browse all the schools in Defiance, MO to learn more.

Home Prices in Defiance, MO

The median home sale price in Defiance, MO is $695,000, up 6% year-over-year. Homes in Defiance sell in 51 days on average, compared to the national average of 57 days.

Home Price Trends

Median Sale Price
$695,000
Median Single Family Sale Price
$695,000
Average Price Per Sq Ft
$232
Number of Homes for Sale
17
Last 12 months Home Sales
54
Months of Supply
3.80
Median List Price
$765,000
Median Change From 1st List Price
4%
Median Home Sale Price YoY Change
6%
How to Buy a Home How to Finance a Home How to Sell a Home

Disclaimer: Certain information contained herein is derived from information provided by parties other than Homes.com. All information provided is deemed reliable, but is not guaranteed to be accurate and should be independently verified.

Homes.com Licensing Information

§ 442-H New York Standard Operating Procedures

New York Fair Housing Notice

TREC: Information about brokerage services, Consumer protection notice

California DRE #01937601

Contact Homes.com Brokerage

Copyright © 2026 CoStar Group