Defiance, MO Homes for Sale with Acreage

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  /87

  $950,000

  Pending

  • 4 Beds
  • 5 Baths
  • 4,298 Sq Ft

  4075 Highway D, Defiance, MO 63341

  Luxury country living meets everyday convenience on this exceptional 10 unrestricted acre estate! Perfectly situated just minutes from Highway 40/61, Highway N, Winghaven shopping, New Melle, Augusta, and Defiance, you’ll enjoy the peace and privacy of country living while remaining close to award-winning wineries, restaurants, shopping, and an easy commute.Beautifully updated and

  

  Samantha Richardson

  Main St. Real Estate

  4075 Highway D, Defiance, MO 63341
• Explore Defiance

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  /43

  $899,999

  $50K PRICE DROP Under Contract

  • 4 Beds
  • 4.5 Baths
  • 4,579 Sq Ft

  50 Sunfish Dr, Defiance, MO 63341

  Experience the best of Callaway Valley living—where privacy, luxury, and lifestyle align.Situated on a stunning 6-acre estate with coveted lake rights, this exceptional property offers a rare blend of space, serenity, and high-end living.The heart of the home is a chef’s dream kitchen, beautifully updated in 2022 with a 48” Wolf gas range with pot filler, Sub-Zero refrigerator, expansive

  

  Amanda Alejandro

  Realty Shop

  50 Sunfish Dr, Defiance, MO 63341
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  /99

  $1,690,000

  $100K PRICE DROP

  • 4 Beds
  • 3.5 Baths
  • 5,609 Sq Ft

  4325 Hueffmeier Rd, Defiance, MO 63341

  Welcome home to this beautifully appointed brick ranch that truly has it all—inside and out. Situated on approximately 10+/- acres, this property offers the perfect blend of privacy, space, and resort-style living. Step into your own private backyard retreat featuring a stunning in-ground saltwater pool (9.5 ft deep), complete with heating and cooling for extended seasonal enjoyment. The

  Scott Dyer MO Realty

  4325 Hueffmeier Rd, Defiance, MO 63341
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  /3

  $199,900

  $100K PRICE DROP

  • Land
  • 3.45 Acres
  • $57,942 per Acre

  0 Defiance Rd Unit 22755774, Defiance, MO 63341

  This expansive 3.45-acre lot is ideally situated in the heart of downtown Defiance, offering a rare combination of space and convenience. The property features a charming, rustic red barn that adds a touch of character and potential for various uses, from storage to creative projects. The ample size of the lot provides plenty of room for development, gardening, or outdoor activities. With its

  MO Realty MO Realty

  0 Defiance Rd Unit 22755774, Defiance, MO 63341
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  /4

  $334,200

  Under Contract

  • Land
  • 5.57 Acres
  • $60,000 per Acre

  28 Meditation Way, Defiance, MO 63341

  Nestled in the heart of St. Charles County in Defiance and near New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 lots already sold in the first

  Toni Dillon Trophy Properties & Auction

  28 Meditation Way, Defiance, MO 63341
• 

  /2

  $375,000

  $50K PRICE DROP

  • Land
  • 8.5 Acres
  • $44,118 per Acre

  0 Defiance Rd Unit MIS26025560, Defiance, MO 63341

  8.5+/- Fabulous acres that offer a combination of open land, level to rolling hills, wooded land & access to a shared pond. Rare opportunity to own this beautiful, very scenic acreage. The perfect place for an equestrian homestead, a country estate, contemporary farmhouse or your DREAM development. This acreage offers seclusion, country style living, with an abundant wildlife habitat for the avid

  Catherine Shaw-Connely Tom Shaw, REALTORS

  0 Defiance Rd Unit MIS26025560, Defiance, MO 63341
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  /6

  $1

  • 3 Beds
  • 4 Baths
  • 2,090 Sq Ft

  1 Country Life, Defiance, MO 63341

  Improvements include a 2090 sq. ft. ranch home built in 1980. The home features 3 bedrooms, 2 full baths & 2 half baths, custom kitchen/breakfast room w/updated stainless steel appliances & granite marble top center island & counter tops, great room w/woodburning stone fireplace, wood floors, formal dining room, formal entry, main floor laundry, huge master bedroom w/large master bath w/tub &

  Dusty Thornhill Thornhill Real Estate & Auction Co

  1 Country Life, Defiance, MO 63341
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  /4

  $587,000

  • Land
  • 5.87 Acres
  • $100,000 per Acre

  4 Cooper's Ct, Defiance, MO 63341

  Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

  Toni Dillon Trophy Properties & Auction

  4 Cooper's Ct, Defiance, MO 63341
• 

  

  /4

  $318,600

  Under Contract

  • Land
  • 5.31 Acres
  • $60,000 per Acre

  36 Meditation Way, Defiance, MO 63341

  Nestled in the heart of St. Charles County in Defiance and near New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 lots already sold in the first

  Toni Dillon Trophy Properties & Auction

  36 Meditation Way, Defiance, MO 63341
• 

  

  /58

  $625,000

  • 4 Beds
  • 2.5 Baths
  • 3,000 Sq Ft

  44 Wilderness Ln, Defiance, MO 63341

  Embrace the serenity of this secluded 3-acre property at the end of a cul-de-sac, surrounded by trees and boasting not just one, but three separate buildings! The main 2-story home features Low Maintenance, Hail resistant Hardi Board Siding, offering possible lower insurance rates. Step inside to find a ceramic tile entry, coat closet, powder room, and a grand staircase with wood rails and

  Mike Simms Worth Clark Realty

  44 Wilderness Ln, Defiance, MO 63341
• 

  

  /4

  $279,900

  • Land
  • 5 Acres
  • $55,980 per Acre

  5011 Lily Ridge, Defiance, MO 63341

  Sunset Estates in St. Charles County MO. Four Luxurious home sites, on 5 acre lots. Located in the heart of Defiance and wine country. Bring your own builder/plans and build your dream home on one of these premium secluded, all wooded lots. Homesites are located on a private street with cul-de-sac. Homeowners will enjoy the peace and quiet, along with privacy. County water and high-speed

  Bill McNair II First American Real Estate Co.

  5011 Lily Ridge, Defiance, MO 63341
• 

  /2

  $449,900

  $35K PRICE DROP

  • Land
  • 9.05 Acres
  • $49,713 per Acre

  2461 Highway F, Defiance, MO 63341

  This mostly level 9.05 Acres of land includes a well with a solar-powered pump and five frost-free spigots on the southeast side—perfect for gardens, orchards, or hobby farming. A gravel driveway has already been added along the south side for convenient access. Only a small portion of the front is in the 100-year floodplain, while the majority of the property sits outside of it, giving you

  Catherine Shaw-Connely Tom Shaw, REALTORS

  2461 Highway F, Defiance, MO 63341
• 

  

  /56

  $850,000

  Pending

  • 5 Beds
  • 5 Baths
  • 4,749 Sq Ft

  769 Old Colony Rd, Defiance, MO 63341

  Experience refined country living in the heart of Missouri wine country at this stunning custom-built brick atrium ranch in Defiance. Nestled on approximately 5 picturesque acres, this exceptional estate offers nearly 5,000 square feet of beautifully finished living space designed for both luxury and comfort. Step inside and be captivated by the dramatic atrium wall of windows that floods the

  Lori Dillick Coldwell Banker Realty - Gundaker

  769 Old Colony Rd, Defiance, MO 63341
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  /70

  $665,999

  Pending

  • 4 Beds
  • 4 Baths
  • 4,025 Sq Ft

  29 Greenview Dr, Defiance, MO 63341

  Set on 9.5 wooded acres, this meticulously maintained 4 bedroom, 4 bath ranch offers the kind of privacy and quiet that is getting harder to find. No traffic noise, no neighbors looking in, just mature timber, rolling terrain and fabulous views in every season. The property even has its own waterfall.Inside, the spacious great room features a vaulted ceiling, skylights and a wall of windows

  Michael Nettemeyer Nettwork Global

  29 Greenview Dr, Defiance, MO 63341
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  /4

  $151,000

  • Land
  • 5.03 Acres
  • $30,020 per Acre

  180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341

  Awesome lot available in a rural subdivision

  Dan Lauderdale Lauderdale Realty

  180 Steeple Point Dr Lot #7 Dr, Defiance, MO 63341
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  /86

  $1,375,000

  $300K PRICE DROP Pending

  • 5 Beds
  • 6 Baths
  • 5,564 Sq Ft

  205 Howell Rd, Defiance, MO 63341

  Welcome to this exceptional custom estate on 3 picturesque acres in Defiance, offering panoramic views with no HOA and no restrictions. Two miles from Chandler Hill and Sugar Creek Winery. Designed for luxury living and incredible functionality, this one-of-a-kind property features 5 bedrooms, 6 full bathrooms, 2 full kitchens, and countless high-end upgrades throughout. The stunning main kitchen

  Yuriy Feldman EXP Realty, LLC

  205 Howell Rd, Defiance, MO 63341
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  /79

  $1,400,000

  • 5 Beds
  • 7 Baths
  • 6,521 Sq Ft

  220 Northlind Dr, Defiance, MO 63341

  Stunning brick and stone ranch-style home sitting on 3 private acres surrounded by mature trees and scenic views! This custom-built home boasts 5 bedrooms, 4 full bathrooms, 3 half bathrooms, and over 6,500 square feet of living space including the finished walkout lower level. The property also features an attached 3 car garage and a detached 52 x 40 foot detached garage with a bonus

  Mark Gellman EXP Realty, LLC

  220 Northlind Dr, Defiance, MO 63341
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  /9

  $151,000

  • Land
  • 5.05 Acres
  • $29,901 per Acre

  130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341

  Great Building Lot. Schedule an appointment and view this property today.

  Dan Lauderdale Lauderdale Realty

  130 Steeple Point Dr Lot #12 Dr, Defiance, MO 63341
• 

  

  /4

  $350,000

  • Land
  • 5 Acres
  • $70,000 per Acre

  517 Callaway Estates Dr, Defiance, MO 63341

  Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

  Stephen Kaiser Trophy Properties & Auction

  517 Callaway Estates Dr, Defiance, MO 63341
• 

  /2

  $152,000

  • Land
  • 5.06 Acres
  • $30,040 per Acre

  120 Steeple Point Dr Lot #13 Dr, Defiance, MO 63341

  Another Great Lot in the Steeple Point Subdivision. Schedule your appointment to view today.

  Dan Lauderdale Lauderdale Realty

  120 Steeple Point Dr Lot #13 Dr, Defiance, MO 63341
• 

  

  /97

  $695,000

  • 3 Beds
  • 2.5 Baths
  • 2,852 Sq Ft

  51 Nordic Ln, Defiance, MO 63341

  Welcome to your dream home - a stunning, cozy, country home nestled in the middle of the woods on 3 acres. This home is an oasis located in St. Charles County wine country, minutes from some of St. Charles ’best hiking & biking trails! This outdoor play scape was designed with the outdoors lover in mind and has ample green-space to enjoy. This remarkable property features an inviting inground

  Mary Bay Coldwell Banker Realty - Gundaker

  51 Nordic Ln, Defiance, MO 63341
• 

  

  /4

  $350,000

  Under Contract

  • Land
  • 5 Acres
  • $70,000 per Acre

  513 Callaway Estates Dr, Defiance, MO 63341

  Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 already sold in the first 18

  Toni Dillon Trophy Properties & Auction

  513 Callaway Estates Dr, Defiance, MO 63341
• 

  

  /15

  $4,422,000

  2323 Highway F, Defiance, MO 63341

  Imagine owning a piece of Missouri history.More than 250 years ago, the Osage people traveled these valleys, and pioneers like Daniel Boone, his son Nathan and adopted son Jonathan Bryan helped shape this remarkable landscape. Today, you have the rare opportunity to own approximately 80 acres of beautiful, untouched land just off Highway F, conveniently located near Augusta and Defiance,

  Catherine Shaw-Connely Tom Shaw, REALTORS

  2323 Highway F, Defiance, MO 63341
• 

  

  /44

  $1,430,000

  $69K PRICE DROP Pending

  • 4 Beds
  • 3.5 Baths
  • 4,461 Sq Ft

  115 Markham Trail Ln, Defiance, MO 63341

  Looking for the perfect multi-generational home or private in-law suite with its own entrance? This custom-built Lombardo Ranch on 5.44 acres checks every box. Thoughtfully designed with high-end upgrades throughout, this home blends style, comfort, and function in every detail.On the main level, you’ll find a chef’s kitchen featuring white custom cabinetry, quartz countertops, a striking

  Madison Lantz Berkshire Hathaway HomeServices Select Properties

  115 Markham Trail Ln, Defiance, MO 63341
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  /74

  $650,000

  • 3 Beds
  • 3 Baths
  • 3,730 Sq Ft

  85 Mar Len Dr, Defiance, MO 63341

  Tucked away on 4.75 beautiful acres surrounded by mature trees, this charming 3-bedroom, 3-bath home offers the perfect blend of privacy, space, and outdoor living. Step inside to a warm and inviting main level featuring vaulted ceilings, skylights, and natural wood accents throughout. The finished lower level provides plenty of additional living space, along with a separate finished room perfect

  Brittany Wasson Christal Property Group, LLC

  85 Mar Len Dr, Defiance, MO 63341
• 

  

  /4

  $350,000

  Under Contract

  • Land
  • 5 Acres
  • $70,000 per Acre

  503 Callaway Estates Dr, Defiance, MO 63341

  Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 40 already sold in the first 18

  Toni Dillon Trophy Properties & Auction

  503 Callaway Estates Dr, Defiance, MO 63341
• 

  

  /36

  $1,150,000

  Pending

  • 6 Beds
  • 5 Baths
  • 5,346 Sq Ft

  620 Forest Meadow Ct, Defiance, MO 63341

  Set on three private acres in Forest Lake Estates within the Francis Howell School District, this 5300+ square foot atrium ranch has been reimagined in its entirety. The kitchen, dining room, great room, bathrooms, flooring, lighting, and paint have all been renewed, allowing the home to feel newly built while retaining the scale and setting only a mature lot can offer. Inside, the great room

  Justin Michael

  620 Forest Meadow Ct, Defiance, MO 63341
• 

  /2

  $238,900

  • Land
  • 8.89 Acres
  • $26,873 per Acre

  110 Steeple Point Dr Lot # 14 Dr, Defiance, MO 63341

  WOW, nearly 9 acres for under $250,000. Schedule an appointment and view this lot today.

  Dan Lauderdale Lauderdale Realty

  110 Steeple Point Dr Lot # 14 Dr, Defiance, MO 63341
• 

  

  /19

  $649,000

  • 3 Beds
  • 2 Baths
  • 2,013 Sq Ft

  215 Rugged Acres Ln, Defiance, MO 63341

  Experience peaceful country living in this stunning 2- year old ranch home nestled on 5 mostly wooded, unrestricted acres in the picturesque Femme Osage Valley. Ideally located just 3.5 miles from the charming town of New Melle, you'll enjoy the perfect balance of privacy and convenience, with nearby wineries, parks, and scenic countryside.This thoughtfully designed home offers 2,013 square

  Stacey Manner Call Dolly, LLC

  215 Rugged Acres Ln, Defiance, MO 63341
• 

  

  /5

  $279,900

  • Land
  • 5 Acres
  • $55,980 per Acre

  5001 Lily Ridge Ct, Defiance, MO 63341

  Four Luxurious home sites, on 5 acre lots. Sunset Estates in St. Charles County MO. Located in the heart of Defiance and wine country. Bring your own builder/plans and build your dream home on one of these premium secluded, all wooded lots. Homesites are located on a private street with cul-de-sac. Homeowners will enjoy the peace and quiet, along with privacy. County water and high-speed

  Bill McNair II First American Real Estate Co.

  5001 Lily Ridge Ct, Defiance, MO 63341
• 

  

  /37

  $520,000

  $29K PRICE DROP

  • 3 Beds
  • 2 Baths
  • 1,600 Sq Ft

  3877 Highway D, Defiance, MO 63341

  Spacious ranch on 6 gorgeous acres conveniently located just minutes from wineries, schools, shopping and highways! This charming 3 bedroom, 2 bath home comes complete with main floor laundry, full, unfinished basement, and a primary bedroom with walk-in closet and ensuite bath. Besides the 2-car attached garage, there is a 28’x60’ insulated metal outbuilding with concrete floor, electric and 220

  Sherry Raleigh-Adams Wolfe Realty

  3877 Highway D, Defiance, MO 63341
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  /4

  $154,000

  • Land
  • 5.13 Acres
  • $30,019 per Acre

  150 Steeple Point Dr Lot #10 Dr, Defiance, MO 63341

  Gorgeous Lot in Steeple Point. Great views and quite living.

  Dan Lauderdale Lauderdale Realty

  150 Steeple Point Dr Lot #10 Dr, Defiance, MO 63341
• 

  

  /10

  $499,900

  Under Contract

  • 3 Beds
  • 2.5 Baths
  • 1,978 Sq Ft

  2540 S Highway 94, Defiance, MO 63341

  Country living on 5.21+/- level STUNNING acres in unincorporated Defiance! A tree lined driveway leads to a CHARMING, RANCH home with 3 bedrooms, 2.5 baths & 1,978+/- SqFt of living space that offers an AWESOME, 30’ x 24’, 2-car, detached garage & shed. Partially covered front porch greets you as you step inside the entry foyer. Step down, living room boasts a floor-to-ceiling brick wood burning

  Catherine Shaw-Connely Tom Shaw, REALTORS

  2540 S Highway 94, Defiance, MO 63341
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  /76

  $579,900

  $40K PRICE DROP

  • 4 Beds
  • 3.5 Baths
  • 3,057 Sq Ft

  8 Whippoorwill Ct, Defiance, MO 63341

  Escape to your own private retreat with this stunning log home nestled on 3 ACRES, where peaceful country living meets modern comfort. Surrounded by mature trees and breathtaking natural beauty, you'll enjoy the serenity of nature while remaining just 15 minutes from Highway 40 and Highway 70, offering the perfect balance of privacy and convenience. Enjoy the view from either the fully covered

  Jennifer Bommarito Fox & Riley Real Estate

  8 Whippoorwill Ct, Defiance, MO 63341
• 

  

  /43

  $599,900

  $100K PRICE DROP Pending

  • 3 Beds
  • 2.5 Baths
  • 1,944 Sq Ft

  1451 Highway F, Defiance, MO 63341

  Rarely does an opportunity like this come available in Defiance! Located in the beautiful Femme Osage valley, nestled on 9+ picturesque acres, this 3 bed, 2.5 home offers the perfect blend of privacy, space, and comfort. The setting is rural but convenient to highway 64/40, Chesterfield, Wentzville, and Francis Howell schools. Step inside to find hardwood floors throughout the main level, leading

  Matthew Lauman Magnolia Real Estate

  1451 Highway F, Defiance, MO 63341
• 

  

  /4

  $350,000

  • Land
  • 5 Acres
  • $70,000 per Acre

  510 Callaway Estates Dr, Defiance, MO 63341

  Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

  Toni Dillon Trophy Properties & Auction

  510 Callaway Estates Dr, Defiance, MO 63341
• 

  

  /54

  $450,000

  Pending

  • 3 Beds
  • 2.5 Baths
  • 1,762 Sq Ft

  9 Wilderness Ln, Defiance, MO 63341

  Welcome to this beautiful 2-story home nestled on 3.9 private acres in the heart of Defiance. Offering 3 bedrooms and 2.5 baths, this property combines peaceful country living with timeless charm.The bright, inviting kitchen features white cabinetry, a center island with an electric cooktop, hardwood floors, and plenty of workspace for cooking and entertaining. The convenient main floor

  Jennifer Gentry Coldwell Banker Realty - Gundaker

  9 Wilderness Ln, Defiance, MO 63341
• 

  

  /40

  $625,000

  $25K PRICE DROP Pending

  • 5 Beds
  • 3 Baths
  • 3,391 Sq Ft

  1510 Highway Dd, Defiance, MO 63341

  Welcome to 1510 Highway DD in unincorporated St. Charles County and in the Francis Howell School District. Nestled on 3 beautiful acres in St. Charles County, this rare 5 bedroom ranch offers the perfect blend of peaceful living while keeping you just minutes from shopping, restaurants, and major highways. Step inside to find an expansive open layout where the kitchen is a true centerpiece,

  Timothy Koppel Berkshire Hathaway HomeServices Select Properties

  1510 Highway Dd, Defiance, MO 63341
• 

  

  /4

  $420,800

  • Land
  • 5.26 Acres
  • $80,055 per Acre

  449 Stones Throw Ct, Defiance, MO 63341

  Nestled in the heart of St. Charles County near Defiance and New Melle, MO, Callaway Lake Estates offers a rare opportunity to build your dream home surrounded by natural beauty while remaining close to modern conveniences. This private community is designed for those seeking space, recreation, and long-term value. The development features 108 homesites, with 35 already sold in the first 18

  Stephen Kaiser Trophy Properties & Auction

  449 Stones Throw Ct, Defiance, MO 63341
• 

  /2

  $290,000

  • Land
  • 10.72 Acres
  • $27,052 per Acre

  190 Steeple Point Dr Lot #6 Dr, Defiance, MO 63341

  Great home site in a rural setting.

  Dan Lauderdale Lauderdale Realty

  190 Steeple Point Dr Lot #6 Dr, Defiance, MO 63341

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