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South San Francisco

South San Francisco

Located in San Mateo County

$1,273,480 Average Value
$860 Average Price per Sq Ft
31 Homes For Sale

The birthplace of biotech on the San Francisco Peninsula

South San Francisco is a dense Peninsula suburb where midcentury homes, landscaped lawns and a cozy downtown district skirt the edge of San Bruno Mountain and the San Francisco Bay. And while it may feel small compared to its northern neighbor, it’s home to some of the world’s biggest biotech companies, including the corporate headquarters of Genentech. “Biotech has been a big boost to the city and its real estate values. It’s also enabled the city to improve its downtown, build new parks and invest in city amenities,” says Realtor Stephen Marshall of Christies International Real Estate, who lives in nearby San Bruno.

The city has come a long way from its founding era. For much of the 20th century, it was known as the “Smokestack capital of the Peninsula” and “The Industrial City” because of its many factories, shipbuilders and manufacturing plants. That began to change in the 1970s and 80s as factories were replaced by major biotech companies like Genentech, Amgen, Exelixis and many others. So robust is this high-tech industry that the city bills itself “the birthplace of biotechnology.” These tech juggernauts are the city’s largest employers, but it still feels like a small bedroom community on the Peninsula. “It’s gotten big in terms of biotech, but it still has a small-town mentality,” says Phil Watson, broker associate at Christies International Real Estate.

The city’s bayside coastline is where the bulk of its biotech firms are located, but it’s also got a few waterfront parks, trails and marinas for residents to enjoy. It’s separated from San Francisco by San Bruno Mountain State Park, a tall peak crisscrossed by hiking paths and dotted with California scrub.

Oyster Point is a busy hub for industry in South San Francisco.
Oyster Point is a busy hub for industry in South San Francisco.
Oyster Point is home to Genentech's enormous campus.
Oyster Point is home to Genentech's enormous campus.
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A bedroom community with a mix of housing options

South San Francisco’s median home price is around $1.3 million, putting it slightly below surrounding cities. Homes spend about 28 days on the market, compared to the national average of 44 days. “It’s a good alternative to places further down on the Peninsula where prices can be much higher,” Watson says. The city's architecture includes everything from historic early 20th-century dwellings to brand-new contemporary homes, but most of its housing stock dates to the post-war construction boom. Ranch homes, split-levels and other popular styles of the era are a common sight in neighborhoods like Sunshine Gardens, Westborough and Serra Highlands. Early 20th-century homes can be found near the city’s historic downtown district, and in neighborhoods like Signal Hill and Paradise Valley. There are also some small farm properties in the city, although they rarely go on the market. “What people don’t realize is there’s a small, unincorporated part of the city on Country Club Drive where people can have horses. So, you’ve got some horse properties that are right in the thick of everything. It’s really unique,” Marshall says.

A row of neat and tidy Mediterranean houses line this street in Sign Hill.
A row of neat and tidy Mediterranean houses line this street in Sign Hill.
A row of brightly colored mid century homes in Serra Highlands.
A row of brightly colored mid century homes in Serra Highlands.
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Cozy, historic Downtown South San Francisco

Downtown South San Francisco is a mellow, historic district of mostly single-story shops and storefronts. Some are historic brick buildings that date back to the city’s earliest days. It’s also where South San Francisco City Hall is, an old Neo-Colonial Georgian building inspired by Philadelphia’s Independence Hall. “It’s a small-town downtown district that’s almost all family-owned businesses. There might be a Starbucks, but other than that you won’t see many chains there. It’s really eclectic, and there’s a lot of good food,” Marshall says. Elsewhere, residents can shop at big box stores and major grocers like Safeway, Costco and Target.

Grand Ave. in Downtown South San Francisco is line with beautifully restored historic buildings.
Grand Ave. in Downtown South San Francisco is line with beautifully restored historic buildings.
Starbucks offers a calm place to work remotely in Downtown South San Francisco.
Starbucks offers a calm place to work remotely in Downtown South San Francisco.
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Hiking trails and bayside scenery

Parks, trails and outdoor recreation are plentiful in South San Francisco. Residents can hike to the top of Sign Hill, where the city’s slogan is spelled out against the slopes in white block letters, or take in the panorama from the brush-laden ridges of San Bruno Mountain. Walkers, joggers and bikers also enjoy access to the San Francisco Bay Trail, which snakes along the water’s edge from San Jose to San Francisco. Community parks, athletic fields and playgrounds are interspersed throughout the city’s neighborhoods. Weather in South San Francisco is typically mild, with warm summers and chilly, rainy winters.

Enjoy a hike at Sign Hill Park in Sign Hill on a warm day.
Enjoy a hike at Sign Hill Park in Sign Hill on a warm day.
Serra Highlands adventurers can parasail at the nearby coast.
Serra Highlands adventurers can parasail at the nearby coast.
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Highly rated San Mateo schools

The South San Francisco Unified School District earns a B-plus rating from Niche, which also ranks it the third-best school division in San Mateo County. It enrolls around 9,000 students across nine elementary schools, three middle schools and three high schools. El Camino High, one of the region’s top-ranked high schools, has a graduation rate of 96% and its academic scores are far above the statewide average, according to state data.

El Camino High School is part of the SSF Unified School District.
El Camino High School is part of the SSF Unified School District.
All Souls Catholic Elementary School in Downtown South San Francisco.
All Souls Catholic Elementary School in Downtown South San Francisco.
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Crime on par with the statewide average

South San Francisco’s violent and property crime rates are about even with the California statewide average, according to FBI stats. The city’s violent crime rates have risen slightly over the past decade, while property crime rates have remained steady.

BART, Caltrain and San Francisco International

South San Francisco is 10 miles from Downtown San Francisco and 25 miles from Silicon Valley cities like Menlo Park and Palo Alto. There’s a BART stop and a Caltrain stop for people who prefer to travel by rail and avoid the Bay Area’s notoriously heavy highway traffic. San Francisco International Airport is 15 miles south. “You’re close to the airport without being right underneath it,” Watson says. Those seeking medical care can go to Kaiser Permanente South San Francisco.

Daniel Berti
Written By
Daniel Berti
Anthony Lindsey
Photography Contributed By
Anthony Lindsey
Pasha Chichagov
Video By
Pasha Chichagov

Interested in learning more about homes in this area? Reach out to Johnny Drake, an experienced agent in this area.

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South San Francisco Housing Trends

Housing Trends

Median List Price
$1,130,000
Median Sale Price
$1,208,888
Median Single Family Sale Price
$1,272,500
Median Townhouse Sale Price
$1,100,000
Median 2 Bedroom Sale Price
$814,000
Median Change From 1st List Price
0%
Last 12 months Home Sales
293
Median Home Sale Price YoY Change
-1%
Average Price Per Sq Ft
$860

Area Facts

Number of Homes
15,292
Number of Homes for Sale
31
Median Year Built
1956
Months of Supply
1.30
Average Single Family Home Size Sq Ft
1,524
Significantly below the national average
1,926
Average Townhouse Size Sq Ft
3,064
Average 2 Bedroom Size Sq Ft
1,042
Average 1 Bedroom Size Sq Ft
782
Median Lot Size Sq Ft
4,791

Open Houses

  • Sunday, Oct 5

    2679 Sean Ct, South San Francisco, CA 94080

    $1,248,000

    • 3 Beds
    • 2.5 Baths
    • 1,850 Sq Ft
    • 2679 Sean Ct
    • New 3 days ago

    Welcome to 2679 Sean Court, a beautifully updated 3-bedroom, 2.5-bathroom home in the desirable Westborough neighborhood of South San Francisco. Filled with natural light, this home offers a thoughtful layout designed for comfort and functionality. The main level features a spacious living room with custom built-in TV cabinets, recessed lighting, and a cozy fireplace, with sliding glass doors

    OWN Real Estate KW Advisors

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  • Sunday, Oct 5

    69 Atlantic Ave, San Bruno, CA 94066

    $1,049,000

    • 3 Beds
    • 1 Bath
    • 1,245 Sq Ft
    • 69 Atlantic Ave
    • New 3 days ago

    Timeless Character Meets Modern Living in San Bruno Built in 1924 and thoughtfully updated, this 3-bedroom, 1-bath residence blends vintage charm with everyday convenience. The open-concept living and dining area flows seamlessly into a skylit kitchen appointed with stainless steel appliances, granite countertops, and a breakfast bar. Of the three comfortable bedrooms, one offers sliding glass

    Bedbury Group Golden Gate Sotheby's International Realty

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  • Sunday, Oct 5

    2779 Duhallow Way, South San Francisco, CA 94080

    $649,000

    • 2 Beds
    • 1.5 Baths
    • 1,040 Sq Ft
    • 2779 Duhallow Way
    • New 2 days ago

    Welcome to this beautiful contemporary 2-bed,1.5-bath townhouse offering comfort, convenience, and stylish touches throughout. Spanning 1,040sqft across two levels, this home has been freshly painted and features new recessed lighting for a modern feel. The well-appointed kitchen overlooks a private front patio and boasts granite countertops, abundant cabinetry including a pull-out pantry, and

    Sonny Chan Sequoia Real Estate

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Homes for Sale

Homes for Rent

Condo Buildings

Distribution of Home Values

Source: Public Records

Average Home Value





Source: Public Records

Neighborhoods in South San Francisco

Property Mix - Square Feet

Weather

Annual Precipitation
20''
Average Winter Low Temperature
44°F
Average Summer High Temperature
73°F
Annual Snowfall
0''

Area Factors

Very Bikeable

Bike Score®®

82 / 100

Somewhat Walkable

Walk Score®®

69 / 100
Source: Walk Score
Source: Walk Score

Walk Score® measures the walkability of any address. Transit Score® measures access to public transit. Bike Score® measures the bikeability of any address. CAP Index provides objective, accurate, and consistent data to help measure, compare, and mitigate crime risks.

Disclaimer: Certain information contained herein is derived from information provided by parties other than Homes.com. Our sources include: Accuweather, Public Records and Neustar. All information provided is deemed reliable, but is not guaranteed to be accurate and should be independently verified.
South San Francisco